Compare Androderm vs. Depo-Testosterone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Androderm
(testosterone patch)

Depo-Testosterone
(testosterone cypionate injection)

Treats low testosterone. The testosterone patch is a topical form of hormone replacement that doesn't affect people you come in contact with, but it can cause skin irritation so you have to rotate its position every night.Treats low testosterone. This testosterone injection only has to be given once or twice a month and you can do it at home, but someone has to help you inject.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Androderm (testosterone patch)
Not enough review data. Review it!
of people (All ages) say Androderm (testosterone patch) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Androderm (testosterone patch)?
Worth itNot sureNot worth it
Reviews for Depo-Testosterone (testosterone cypionate injection)
49%
-18% worse vs. Androderm (testosterone patch)
32%
-35% worse vs. Androderm (testosterone patch)
17%
-17% worse vs. Androderm (testosterone patch)
100 reviews
Have you used Depo-Testosterone (testosterone cypionate injection)?
Worth itNot sureNot worth it
Side effects
AndrodermDepo-Testosterone
  • Any appication site reaction 28%
  • Application site pruritus 17%
  • Application site vesicles 6%
  • Back pain 6%
  • Application site erythema 3%
  • Application site exfoliation 3%
  • Chills 3%
  • Prostatitis 3%
  • Fatigue 3%
  • Acid reflux disease 3%
More Androderm side effects »

The Depo-Testosterone FDA package insert doesn’t have numbers about how common side effects are.

More about Depo-Testosterone side effects »
How it works
AndrodermDepo-Testosterone
The testosterone patch works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.The testosterone injection works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
AndrodermDepo-Testosterone
Prescription only
Prescription only
Available as
AndrodermDepo-Testosterone
  • Patch
  • Injection
Used for
AndrodermDepo-Testosterone
  • Low Testosterone
  • Low Testosterone
Risk factors for serious side effects
AndrodermDepo-Testosterone
    Coming soon.
    • Male
    • Enlarged prostate (benign prostatic hypertrophy)
    • Taking high doses of Depo-Testosterone (Testosterone Cypionate Injection)
    • Heart, liver or kidney disease
    Detailed Depo-Testosterone (testosterone cypionate injection) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Kidneys and liver
    AndrodermDepo-Testosterone
    No kidneys and liver related info.
    • There have been reports of people on Depo-Testosterone (Testosterone Cypionate Injection) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This can happen if you are unable to move around or have cancer. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
    Upsides and benefits
    AndrodermDepo-Testosterone
    • The testosterone patch doesn't have to be removed when you're having sex or if you're showering or bathing.
    • The testosterone patch prevents other people around you from coming in contact with testosterone, unlike other topical forms such as gels.
    • The testosterone patch only has to be placed once each night.
    • A first-choice treatment for low testosterone in men and delayed puberty in boys.
    • Available in generic.
    • Only has to be given once every 2 to 4 weeks.
    • The shot can be done at home.
    Downsides and risks
    AndrodermDepo-Testosterone
    • Not available in generic.
    • You have to be careful to rotate the testosterone patch to a different part of your body each night.
    • Can cause skin irritation.
    • Has to be removed before you have an MRI.
    • The patch can become loose if you do heavy exercise or sweat a lot.
    • Only available as a shot.
    • Has to be given by someone else since it has to be injected into your buttocks.
    Tips from our pharmacists for people taking the medication
    AndrodermDepo-Testosterone
    • Place the testosterone patch on a clean, dry area of your skin each night. Don't put it on your scrotum or a bony part of your body.
    • Change the area where you place the testosterone patch every night, and wait at least 7 days before you put in on the same site again.
    • Make sure the patch is attached to your skin, especially along the edges. If it loosens, smooth the edges and then the center of the patch with your finger to make sure it's attached completely.
    • If the patch falls off before noon, apply another patch. If it falls off after that, don't apply another patch until your regular time at night. Don't use tape to keep the patch attached.
    • Don't bathe or swim for at least 3 hours after you put a new patch on. Also, heavy exercise or lots of sweating can make your patch fall off.
    • Your doctor will show you how to inject this correctly.
    • Can cause nausea, vomiting and headache.
    • Can cause increased acne and changes in sex drive.
    • Keep this medication locked up and away from children since it's a controlled substance.
    Learn more
    More about AndrodermSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Androderm (testosterone patch)?
    Worth itNot sureNot worth it
    More about Depo-TestosteroneSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Depo-Testosterone (testosterone cypionate injection)?
    Worth itNot sureNot worth it