Compare Androgel vs. Axiron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Androgel
(Testosterone Gel)

Axiron
(Testosterone Topical Solution)

Treats low testosterone. This testosterone gel is a convenient topical form of hormone replacement, but you have to be careful about it rubbing off on other people. Also it can be cheaper than alternatives.Treats low testosterone. This testosterone topical solution is a convenient topical form of hormone replacement that's less likely to rub off on other people you come into contact with, but it's not available as a generic yet.
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Reviews & ratings
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Side effects
AndrogelAxiron

The Androgel FDA package insert doesn’t have numbers about how common side effects are.

More about Androgel side effects »

The Axiron FDA package insert doesn’t have numbers about how common side effects are.

More about Axiron side effects »
How it works
AndrogelAxiron
Testosterone gel works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.Testosterone topical solution works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
AndrogelAxiron
Hormone replacement
Testosterone
Prescription only
Hormone replacement
Testosterone
Prescription only
Available as
AndrogelAxiron
  • Cream, gel, or ointment
  • Topical
Used for (click to learn more)
AndrogelAxiron
  • Low testosterone
  • Low testosterone
Risk factors for serious side effects
AndrogelAxiron
Coming soon.Coming soon.
Pregnancy category
AndrogelAxiron
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
AndrogelAxiron
  • You put it on like a lotion, so it's very easy to apply.
  • Available in generic, so it's cheaper than some alternatives.
  • You're less likely with this formulation to transfer testosterone topical solution to another person since this is applied to the armpits -- unlike some other forms of topical testosterone.
  • You can use your regular deodorant or antiperspirant, but just make sure to apply that first before using testosterone topical solution.
Downsides and risks
AndrogelAxiron
  • You have to make sure that you cover the area where you place testosterone gel after it's dry, otherwise it can rub off on people.
  • You have to wait at least 2 hours before you shower or swim after putting on Testosterone gel, otherwise your body won't absorb the entire amount.
  • Only available as brand name.
  • You have to wait at least 2 hours after applying testosterone topical solution before you can swim or bathe, otherwise your body won't absorb the entire amount.
Tips from our pharmacists for people taking the medication
AndrogelAxiron
  • How to put it on: Don't put testosterone gel anywhere else except where you're taught by the doctor or pharmacist, usually the shoulders and upper arms. Don't put it around your genitals. Wash your hands with soap and water and dry them afterward. Cover the area with clothing as soon as it's dry so you don't spread it to other people.
  • Don't bathe or swim for at least 2 hours after you've put on testosterone gel so that it has time to absorb.
  • If you think you'll have skin-to-skin contact with someone else at the area where you've placed testosterone gel, wash that area with soap and water and dry. If someone else touches the area before you've washed it off, have them wash their skin with soap and water as soon as they can.
  • Prime testosterone topical solution first by pumping 3 times before you use a new bottle.
  • If you use deodorant or antiperspirant, apply that first before using testosterone topical solution.
  • Don't swim or bathe for at least 2 hours after you put on testosterone topical solution so that it has time to absorb.
  • Cover the area with clothing as soon as it's dry so you don't spread it to other people.
  • If you think you'll have skin-to-skin contact at the area where you've placed testosterone topical solution, wash that area with soap and water then dry.
  • Don't use testosterone topical solution anywhere besides your armpits.
Learn more
More about AndrogelSide effectsReviews & ratingsAlternativesFDA package insert
More about AxironSide effectsReviews & ratingsAlternativesFDA package insert