Compare Androgel vs. Axiron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Androgel
(testosterone gel)

Axiron
(testosterone topical solution)

Treats low testosterone. This testosterone gel is a convenient topical form of hormone replacement, but you have to be careful about it rubbing off on other people. Also it can be cheaper than alternatives.Treats low testosterone. This testosterone topical solution is a convenient topical form of hormone replacement that's less likely to rub off on other people you come into contact with, but it's not available as a generic yet.
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Reviews & ratings
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Have you used Androgel (testosterone gel)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Axiron (testosterone topical solution)?
Worth itNot sureNot worth it
Side effects
AndrogelAxiron
  • Psa increased 11%
  • Any adverse reaction 11%
  • Mood swings 3%
  • High blood pressure 2%
  • Hematocrit or hemoglobin increased 2%
  • Rash 2%
More Androgel side effects »
  • Application site irritation 8%
  • Hematocrit increased 7%
  • Application site erythema 7%
  • Headache 6%
  • Diarrhea 4%
  • Vomiting 4%
  • Psa increased 4%
More Axiron side effects »
How it works
AndrogelAxiron
Testosterone gel works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.Testosterone topical solution works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
AndrogelAxiron
Prescription only
Prescription only
Available as
AndrogelAxiron
  • Cream, gel, or ointment
  • Topical
Used for
AndrogelAxiron
  • Low Testosterone
  • Low Testosterone
Risk factors for serious side effects
AndrogelAxiron
Coming soon.Coming soon.
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Upsides and benefits
AndrogelAxiron
  • You put it on like a lotion, so it's very easy to apply.
  • Available in generic, so it's cheaper than some alternatives.
  • You're less likely with this formulation to transfer testosterone topical solution to another person since this is applied to the armpits -- unlike some other forms of topical testosterone.
  • You can use your regular deodorant or antiperspirant, but just make sure to apply that first before using testosterone topical solution.
Downsides and risks
AndrogelAxiron
  • You have to make sure that you cover the area where you place testosterone gel after it's dry, otherwise it can rub off on people.
  • You have to wait at least 2 hours before you shower or swim after putting on Testosterone gel, otherwise your body won't absorb the entire amount.
  • Only available as brand name.
  • You have to wait at least 2 hours after applying testosterone topical solution before you can swim or bathe, otherwise your body won't absorb the entire amount.
Tips from our pharmacists for people taking the medication
AndrogelAxiron
  • How to put it on: Don't put testosterone gel anywhere else except where you're taught by the doctor or pharmacist, usually the shoulders and upper arms. Don't put it around your genitals. Wash your hands with soap and water and dry them afterward. Cover the area with clothing as soon as it's dry so you don't spread it to other people.
  • Don't bathe or swim for at least 2 hours after you've put on testosterone gel so that it has time to absorb.
  • If you think you'll have skin-to-skin contact with someone else at the area where you've placed testosterone gel, wash that area with soap and water and dry. If someone else touches the area before you've washed it off, have them wash their skin with soap and water as soon as they can.
  • Prime testosterone topical solution first by pumping 3 times before you use a new bottle.
  • If you use deodorant or antiperspirant, apply that first before using testosterone topical solution.
  • Don't swim or bathe for at least 2 hours after you put on testosterone topical solution so that it has time to absorb.
  • Cover the area with clothing as soon as it's dry so you don't spread it to other people.
  • If you think you'll have skin-to-skin contact at the area where you've placed testosterone topical solution, wash that area with soap and water then dry.
  • Don't use testosterone topical solution anywhere besides your armpits.
Learn more
More about AndrogelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Androgel (testosterone gel)?
Worth itNot sureNot worth it
More about AxironSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Axiron (testosterone topical solution)?
Worth itNot sureNot worth it