Compare Androgel vs. Depo-Testosterone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats low testosterone.

This testosterone gel is a convenient topical form of hormone replacement, but you have to be careful about it rubbing off on other people. Also it can be cheaper than alternatives.

Treats low testosterone.

This testosterone injection only has to be given once or twice a month and you can do it at home, but someone has to help you inject.

3.0/ 5 average rating with 100 reviewsforDepo-Testosterone
Upsides
  • You put it on like a lotion, so it's very easy to apply.
  • Available in generic, so it's cheaper than some alternatives.
  • A first-choice treatment for low testosterone in men and delayed puberty in boys.
  • Available in generic.
  • Only has to be given once every 2 to 4 weeks.
  • The shot can be done at home.
Downsides
  • You have to make sure that you cover the area where you place testosterone gel after it's dry, otherwise it can rub off on people.
  • You have to wait at least 2 hours before you shower or swim after putting on Testosterone gel, otherwise your body won't absorb the entire amount.
  • Only available as a shot.
  • Has to be given by someone else since it has to be injected into your buttocks.
Used for
  • Low testosterone
  • Low testosterone
Dosage forms
  • Cream, gel, or ointment
  • Injection
Price
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Reviews
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100 reviews so far
49%
saidit'sworth it
32%
saiditworked well
17%
saidit'sa big hassle

Have you used Depo-Testosterone (Testosterone Cypionate Injection)?

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Side effects
6possible side effects
  • PSA increased
    11%
  • Any adverse reaction
    11%
  • Emotional lability
    3%
  • Hypertension
    2%
  • Hematocrit or hemoglobin increased
    2%
  • Contact dermatitis
    2%
See more detailed side effects
The Depo-Testosterone (Testosterone Cypionate Injection) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
No information currently available
  • Breast tissue changes
    • Male
  • Changes in sex drive
    • Male
  • Inability to urinate
    • Enlarged prostate (benign prostatic hypertrophy)
  • Changes in sperm
    • Taking high doses of Depo-Testosterone (Testosterone Cypionate Injection)
  • Swelling in the legs
    • Heart, liver or kidney disease
  • High calcium in the blood
    • Inability to move
    • Cancer
  • Liver disease
  • Changes in mood
  • Changes in blood sugar
    • Diabetes
  • Changes in blood thinning
    • On blood thinners
  • Blood clots
See more detailed risks and warnings