Compare Angeliq vs. Combipatch

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Angeliq
(drospirenone / estradiol)

Combipatch
(estradiol / norethindrone patch)

Relieves hot flashes and vaginal dryness due to menopause. Angeliq (drospirenone / estradiol) helps relieve menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.Treats low estrogen and relieves menopause symptoms. Combipatch (Estradiol / Norethindrone Patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combo medications, but prefer to use a patch every twice a week instead of pills every day.
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Coupons for Angeliq
Best available price for 1 (28 tablets of 0.5mg/1mg) package of angeliq
Coupons for Combipatch
Best available price for 1 (8 patches of 0.05mg/0.14mg) package of combipatch
Reviews & ratings
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Have you used Angeliq (drospirenone / estradiol)?
Worth itNot sureNot worth it

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Have you used Combipatch (estradiol / norethindrone patch)?
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Side effects
AngeliqCombipatch
  • Stomach pain 3%
  • Headache 1%
  • Yeast infections 5%
  • Breast pain 2%
  • Nausea 2%
  • Diarrhea 1%
  • Swelling of arms and legs 1%
  • Vaginal bleeding 14%
More Angeliq side effects »
  • Breast pain 18%
  • Menstrual cramps 15%
  • Back pain 6%
  • Nausea 4%
  • Flu syndrome 2%
  • Papanicolaou smear suspicious 3%
  • Muscle weakness 4%
  • Abdominal pain 3%
More Combipatch side effects »
How it works
AngeliqCombipatch
Angeliq (drospirenone / estradiol) is a combination medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Drospirenone (a progestin) protects the uterus from damage.Combipatch (Estradiol / Norethindrone Patch) is an estrogen/progestin combination patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.
Type of medication
AngeliqCombipatch
Prescription onlyPrescription only
Available as
AngeliqCombipatch
  • Pill
  • Patch
Used for
AngeliqCombipatch
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
AngeliqCombipatch
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Angeliq (drospirenone / estradiol) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Combipatch (estradiol / norethindrone patch) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Weight
AngeliqCombipatch
No weight related info.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Combipatch (Estradiol / Norethindrone Patch) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
Upsides and benefits
AngeliqCombipatch
  • Angeliq (drospirenone / estradiol) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Useful for women who experience moderate to severe symptoms of menopause.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Twice-a-week patch. Good for people who don't want to take daily pills.
  • Combipatch (Estradiol / Norethindrone Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Good for women with an intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
Downsides and risks
AngeliqCombipatch
  • There are more possible side effects since it exposes your whole body to two hormones.
  • Angeliq (drospirenone / estradiol) can't be used by women who have had their uterus removed.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Compared to other estrogen-progestin combination medicines, you might be more likely to have blood clots with Angeliq (drospirenone / estradiol).
  • Angeliq (drospirenone / estradiol) might increase your potassium, which can be dangerous if you're taking other medicines that do the same.
  • More potential side effects than single-ingredient medications since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Patch can fall off.
  • Can be expensive since it's only available as a brand name product.
Tips from our pharmacists for people taking the medication
AngeliqCombipatch
  • You can get some bleeding if you miss several doses in a row.
  • If you miss a pill and it's been more than 24 hours since you were supposed to take it, skip it and continue your normal dose. Don't ever take a double dose.
  • You and your doctor should regularly talk about how long to use Angeliq (drospirenone / estradiol). The longer you are on it, the more likely you are to have problems from it.
  • Can cause nausea, dizziness, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Tell your doctor or go to an emergency room if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about AngeliqSide effectsAlternativesFDA package insert
Have you used Angeliq (drospirenone / estradiol)?
Worth itNot sureNot worth it
More about CombipatchSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Combipatch (estradiol / norethindrone patch)?
Worth itNot sureNot worth it