Compare Angeliq vs. Combipatch

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Angeliq
(drospirenone / estradiol)

Combipatch
(estradiol / norethindrone patch)

Relieves hot flashes and vaginal dryness due to menopause. Angeliq (drospirenone / estradiol) helps relieve menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.Treats low estrogen and relieves menopause symptoms. Combipatch (estradiol / norethindrone patch) is a twice weekly patch that effectively treats menopause and causes less blood clots or stroke than combination pills.
Reviews & ratings
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Have you used Angeliq (drospirenone / estradiol)?
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Side effects
AngeliqCombipatch
  • Stomach pain 3%
  • Headache 1%
  • Yeast infections 5%
  • Breast pain 2%
  • Nausea 2%
  • Diarrhea 1%
  • Swelling of arms and legs 1%
  • Vaginal Bleeding 14%
More Angeliq side effects »
  • Breast pain 18%
  • Menstrual cramps 15%
  • Back pain 6%
  • Nausea 4%
  • Flu like symptoms 2%
  • Abnormal pap smear 3%
  • Weakness 4%
  • Stomach pain 3%
More Combipatch side effects »
How it works
AngeliqCombipatch
Angeliq (drospirenone / estradiol) is a combination medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Drospirenone (a progestin) protects the uterus from damage.Combipatch (estradiol / norethindrone patch) is a combination patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Norethindrone (a progestin) protects the uterus from damage.
Type of medication
AngeliqCombipatch
Prescription onlyPrescription only
Available as
AngeliqCombipatch
  • Pill
  • Patch
Used for
AngeliqCombipatch
Risk factors for serious side effects
AngeliqCombipatch
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Angeliq (drospirenone / estradiol) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Combipatch (estradiol / norethindrone patch) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Upsides and benefits
AngeliqCombipatch
  • Angeliq (drospirenone / estradiol) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Useful for women who experience moderate to severe symptoms of menopause.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Twice weekly patch. Good for people who don't want to take daily pills.
  • Replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Less likely to cause blood clots or stroke than pills since patches contain a lower amount of hormones.
  • Good for women with an intact uterus.
  • You can bathe, shower, and swim while wearing the patch, as long as you don't rub the patch.
Downsides and risks
AngeliqCombipatch
  • There are more possible side effects since it exposes your whole body to two hormones.
  • Angeliq (drospirenone / estradiol) can't be used by women who have had their uterus removed.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Compared to other estrogen-progestin combination medicines, you might be more likely to have blood clots with Angeliq (drospirenone / estradiol).
  • Angeliq (drospirenone / estradiol) might increase your potassium, which can be dangerous if you're taking other medicines that do the same.
  • More potential side effects than single ingredient medications since it exposes your whole body to two hormones.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can't be exposed to direct sunlight for long periods of time.
  • Can be expensive since it's only available as a brand name product.
Tips from our pharmacists for people taking the medication
AngeliqCombipatch
  • You can get some bleeding if you miss several doses in a row.
  • If you miss a pill and it's been more than 24 hours since you were supposed to take it, skip it and continue your normal dose. Don't ever take a double dose.
  • You and your doctor should regularly talk about how long to use Angeliq (drospirenone / estradiol). The longer you are on it, the more likely you are to have problems from it.
  • Can cause nausea, dizziness, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Tell your doctor or go to an emergency room if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin on your lower belly as directed by the manufacturer. Press the patch firmly in place for 10 seconds, especially around the edges. Don't place it at your waistline or on your breasts.
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to help prevent skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Combipatch (estradiol / norethindrone patch) is not intended to be used forever. Talk to your doctor regularly to see if you still need treatment.
Learn more
More about AngeliqSide effectsAlternativesFDA package insert
Have you used Angeliq (drospirenone / estradiol)?
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More about CombipatchSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Combipatch (estradiol / norethindrone patch)?
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