Compare Angeliq vs. Estrace

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Angeliq
(drospirenone / estradiol)

Estrace
(estradiol)

Relieves hot flashes and vaginal dryness due to menopause. Angeliq (drospirenone / estradiol) helps relieve menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Estrace (Estradiol) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.
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Coupons for Angeliq
Best available price for 28 (28 tablets of 0.5mg/1mg) packages of angeliq
Coupons for Estrace
Best available price for 30 (1mg) tablets of estrace
Reviews & ratings
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Have you used Angeliq (drospirenone / estradiol)?
Worth itNot sureNot worth it

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Have you used Estrace (estradiol)?
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Side effects
AngeliqEstrace
  • Stomach pain 3%
  • Headache 1%
  • Yeast infections 5%
  • Breast pain 2%
  • Nausea 2%
  • Diarrhea 1%
  • Swelling of arms and legs 1%
  • Vaginal bleeding 14%
More Angeliq side effects »

The Estrace FDA package insert doesn’t have numbers about how common side effects are.

More about Estrace side effects »
How it works
AngeliqEstrace
Angeliq (drospirenone / estradiol) is a combination medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Drospirenone (a progestin) protects the uterus from damage.Estrace (Estradiol) is an oral medication that replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.
Type of medication
AngeliqEstrace
Prescription onlyPrescription only
Available as
AngeliqEstrace
  • Pill
  • Pill
Used for
AngeliqEstrace
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
AngeliqEstrace
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Angeliq (drospirenone / estradiol) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Estrace (estradiol) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Pain
AngeliqEstrace
No pain related info.
  • Estrogens like Estrace (Estradiol) can increase the risk of gallbladder disease, sometimes needing surgery. Let your doctor know if you have nausea, vomiting, bloating, or severe stomach pain that won't go away.
Weight
AngeliqEstrace
No weight related info.
  • Can cause nausea, dizziness, bloating and breast tenderness.
Upsides and benefits
AngeliqEstrace
  • Angeliq (drospirenone / estradiol) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Useful for women who experience moderate to severe symptoms of menopause.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Estrace (Estradiol) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Doesn't expose your partner to estrogen during sexual acitivities like the vaginal estrogen creams.
  • Can help relieve symptoms of advanced prostate or breast cancer in some people.
Downsides and risks
AngeliqEstrace
  • There are more possible side effects since it exposes your whole body to two hormones.
  • Angeliq (drospirenone / estradiol) can't be used by women who have had their uterus removed.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Compared to other estrogen-progestin combination medicines, you might be more likely to have blood clots with Angeliq (drospirenone / estradiol).
  • Angeliq (drospirenone / estradiol) might increase your potassium, which can be dangerous if you're taking other medicines that do the same.
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Estrace (Estradiol) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
Tips from our pharmacists for people taking the medication
AngeliqEstrace
  • You can get some bleeding if you miss several doses in a row.
  • If you miss a pill and it's been more than 24 hours since you were supposed to take it, skip it and continue your normal dose. Don't ever take a double dose.
  • You and your doctor should regularly talk about how long to use Angeliq (drospirenone / estradiol). The longer you are on it, the more likely you are to have problems from it.
  • Can cause nausea, dizziness, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Tell your doctor or go to an emergency room if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Take Estrace (Estradiol) exactly the way your doctor tells you since the dose and dosing cycle may be different depending on what you're being treated for.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment. If you’re taking Estrace (Estradiol) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause or non-estrogen medicine for bone loss).
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about AngeliqSide effectsAlternativesFDA package insert
Have you used Angeliq (drospirenone / estradiol)?
Worth itNot sureNot worth it
More about EstraceSide effectsAlternativesFDA package insert
Have you used Estrace (estradiol)?
Worth itNot sureNot worth it