Compare Angeliq vs. Estrace

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Angeliq (drospirenone / estradiol)

Prescription only

Estrace (Estradiol)

Prescription only
Relieves hot flashes and vaginal dryness due to menopause.

Angeliq (drospirenone / estradiol) helps relieve menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.

Relieves hot flashes and vaginal symptoms related to menopause.

Estrace (Estradiol) treats symptoms of menopause, but causes more of side effects than other medicines like it.

Upsides
  • Angeliq (drospirenone / estradiol) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Useful for women who experience moderate to severe symptoms of menopause.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Estrace (Estradiol) comes as a pill and is much easier to use compared to the cream form.
  • Available as a cheaper, generic version.
  • Usually you only need to take DRUG NAME for a short amount of time.
Downsides
  • There are more possible side effects since it exposes your whole body to two hormones.
  • Angeliq (drospirenone / estradiol) can't be used by women who have had their uterus removed.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Compared to other estrogen-progestin combination medicines, you might be more likely to have blood clots with Angeliq (drospirenone / estradiol).
  • Angeliq (drospirenone / estradiol) might increase your potassium, which can be dangerous if you're taking other medicines that do the same.
  • Associated with a higher risk for side effects like blood clots, stroke, and cancer compared to its cream formulation.
  • DRUG_ NAME can increase the risk of memory loss for women age 65 or older.
  • Your doctor might frequently change your dose of the medicine in the beginning until your symptoms are well-controlled.
  • Not recommended for women who need treatment only for vaginal dryness and itching.
Used for
  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
  • Metastatic breast cancer
  • Advanced prostate cancer
Dosage forms
  • Pill
  • Pill
Price
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$171.4
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Lowest price near you
$38.07
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Reviews
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Side effects
7possible side effects
  • Stomach pain
    6%
  • Headache
    6%
  • Yeast infections
    6%
  • Breast pain
    3%
  • Nausea
    3%
  • Diarrhea
    2%
  • Swelling of arms and legs
    2%
See more detailed side effects
The Estrace (Estradiol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 3 more risk factors

  • Increased risk of heart disease

    Smoking

    ...and 5 more risk factors

  • Dementia

    Age 65 or older

  • Increased potassium

    Kidney disease

    ...and 3 more risk factors

See more detailed risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 3 more risk factors

  • Increased risk of heart disease

    Smoking

    ...and 5 more risk factors

  • Dementia

    Age 65 or older

  • Inflammation of pancreas

    High levels of triglycerides

See more detailed risks and warnings