Compare Angeliq vs. Prefest

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Angeliq
(Drospirenone / Estradiol)

Prefest
(Estradiol / Norgestimate)

Relieves hot flashes and vaginal dryness due to menopause. Angeliq (Drospirenone / Estradiol) helps relieve menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.Relieves menopause symptoms and lowers your risk of osteoporosis. Prefest (Estradiol / Norgestimate) is effective at treating symptoms related to menopause and bone loss. It has a difficult dosing schedule to follow, but doesn't affect your cholesterol and triglyceride levels as much as other estrogen products.
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Reviews & ratings
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Have you used Angeliq (Drospirenone / Estradiol)?
Worth itNot sureNot worth it

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Have you used Prefest (Estradiol / Norgestimate)?
Worth itNot sureNot worth it
Side effects
AngeliqPrefest
  • Yeast infections 5%
  • Nausea 2%
  • Swelling of arms and legs 1%
  • Diarrhea 1%
  • Headache 1%
More Angeliq side effects »

The Prefest FDA package insert doesn’t have numbers about how common side effects are.

More about Prefest side effects »
How it works
AngeliqPrefest
Angeliq (Drospirenone / Estradiol) is a combination medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Drospirenone (a progestin) protects the uterus from damage.Prefest (Estradiol / Norgestimate) is a combination oral medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norgestimate (a progestin) protects the uterus from damage.
Type of medication
AngeliqPrefest
Hormone replacement
Progestin
Prescription only
Hormone replacement
Estrogen
Progestin
Prescription only
Available as
AngeliqPrefest
  • Pill
  • Pill
Used for (click to learn more)
AngeliqPrefest
  • Hot flashes and night sweats
Risk factors for serious side effects
AngeliqPrefest
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
Detailed risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Weight
AngeliqPrefest
No weight related info.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Prefest (Estradiol / Norgestimate) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
Upsides and benefits
AngeliqPrefest
  • Angeliq (Drospirenone / Estradiol) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Useful for women who experience moderate to severe symptoms of menopause.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Improves mood, energy, and mental alertness for some people.
  • Prefest (Estradiol / Norgestimate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Good for women with an intact uterus. The norgestimate (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Doesn't affect your cholesterol levels as much as other estrogen treatments.
  • Improves mood, energy, and mental alertness for some people.
Downsides and risks
AngeliqPrefest
  • There are more possible side effects since it exposes your whole body to two hormones.
  • Angeliq (Drospirenone / Estradiol) can't be used by women who have had their uterus removed.
  • Compared to other estrogen-progestin combination medicines, you might be more likely to have blood clots with Angeliq (Drospirenone / Estradiol).
  • Angeliq (Drospirenone / Estradiol) might increase your potassium, which can be dangerous if you're taking other medicines that do the same.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norgestimate (a progestin).
  • Dosing schedule can be hard to follow with the 2 different kind of pills (estrogen-only and estrogen/progestin pills).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Tips from our pharmacists for people taking the medication
AngeliqPrefest
  • You can get some bleeding if you miss several doses in a row.
  • If you miss a pill and it's been more than 24 hours since you were supposed to take it, skip it and continue your normal dose. Don't ever take a double dose.
  • You and your doctor should regularly talk about how long to use Angeliq (Drospirenone / Estradiol). The longer you are on it, the more likely you are to have problems from it.
  • Can cause nausea, dizziness, and breast tenderness.
  • Tell your doctor or go to an emergency room if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Tell your doctor about any unusual vaginal bleeding.
  • Follow the dosing schedule exactly to take the estrogen-only and combination estrogen/progestin pills.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Tell your doctor about any unusual vaginal bleeding.
Learn more
More about AngeliqSide effectsAlternativesFDA package insert
Have you used Angeliq (Drospirenone / Estradiol)?
Worth itNot sureNot worth it
More about PrefestSide effectsAlternativesFDA package insert
Have you used Prefest (Estradiol / Norgestimate)?
Worth itNot sureNot worth it