Compare Angeliq vs. Prefest

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Angeliq
(Drospirenone / Estradiol)

Prefest
(Estradiol / Norgestimate)

Relieves hot flashes and vaginal dryness due to menopause. Angeliq (Drospirenone / Estradiol) effectively relieves menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.Relieves menopause symptoms and lowers your risk of osteoporosis. Prefest (Estradiol / Norgestimate) is effective at treating symptoms related to menopause and bone loss. It has a difficult dosing schedule to follow, but doesn't affect your cholesterol and triglyceride levels as much as other estrogen products.
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Reviews & ratings
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Side effects
AngeliqPrefest
  • Vulvovaginal fungal infections 5%
  • Gastrointestinal and abdominal pains 3%
  • Nausea 2%
  • Breast pain 2%
  • Leg or ankle swelling 1%
  • Diarrhea 1%
  • Headache 1%
More Angeliq side effects »

The Prefest FDA package insert doesn’t have numbers about how common side effects are.

More about Prefest side effects »
How it works
AngeliqPrefest
Angeliq (Drospirenone / Estradiol) is a combination medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats, but can also harm cells in the uterus after menopause. Drospirenone (a progestin) protects the uterus from damage.Prefest (Estradiol / Norgestimate) is a combination oral medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norgestimate (a progestin) protects the uterus from damage.
Type of medication
AngeliqPrefest
Hormone replacement
Progestin
Estrogen
Prescription only
Hormone replacement
Estrogen
Progestin
Prescription only
Available as
AngeliqPrefest
  • Pill
  • Pill
Used for (click to learn more)
AngeliqPrefest
  • Hot flashes and night sweats
  • Hot flashes and night sweats
Risk factors for serious side effects
AngeliqPrefest
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Women of childbearing age
  • High levels of triglycerides
  • Family history of ovarian cancer
Detailed Angeliq (Drospirenone / Estradiol) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Women of childbearing age
  • High levels of triglycerides
  • Family history of ovarian cancer
Detailed Prefest (Estradiol / Norgestimate) risks & warnings »
Pregnancy category
AngeliqPrefest
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
  • Decreased bloating and possible weight loss from the drospirenone, which has diuretic properties (helps your body get rid of water through urination).
No specific weight-related info.
Upsides and benefits
AngeliqPrefest
  • Angeliq (Drospirenone / Estradiol) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Decreased bloating and possible weight loss from the drospirenone, which has diuretic properties (helps your body get rid of water through urination).
  • Improves mood, energy, and mental alertness for some people.
  • Prefest (Estradiol / Norgestimate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Good for women with an intact uterus. The norgestimate (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Doesn't affect your cholesterol levels as much as other estrogen treatments.
  • Improves mood, energy, and mental alertness for some people.
Downsides and risks
AngeliqPrefest
  • More potential side effects since it exposes your whole body to two hormones, estrogen and drospirenone (a progestin).
  • Has a slightly higher risk of blood clots compared to other estrogen-progestin combination pills because of the type of progestin it contains (drospirenone).
  • Must be used carefully with any other medicine that can increase your potassium level.
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norgestimate (a progestin).
  • Dosing schedule can be hard to follow with the 2 different kind of pills (estrogen-only and estrogen/progestin pills).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Tips from our pharmacists for people taking the medication
AngeliqPrefest
  • You can get some bleeding if you miss several doses in a row.
  • Can cause nausea, dizziness, and breast tenderness.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Follow the dosing schedule exactly to take the estrogen-only and combination estrogen/progestin pills.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about AngeliqSide effectsAlternativesFDA package insert
More about PrefestSide effectsAlternativesFDA package insert