Compare Apidra vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Apidra
(insulin glulisine)

Glucotrol
(glipizide)

Controls blood sugar. Apidra (insulin glulisine) is an insulin that controls blood sugar during your meals, but you'll still have to follow your doctor's diet and exercise plan.Lowers blood sugar. Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.
Reviews & ratings
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Have you used Apidra (insulin glulisine)?
Worth itNot sureNot worth it
Reviews for Glucotrol
50%
+50% better vs. Apidra
32%
+68% better vs. Apidra
19%
+19% better vs. Apidra
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Side effects
ApidraGlucotrol
  • Common cold 11%
  • Upper respiratory tract infection 8%
  • Low blood sugar 7%
  • Headache 7%
  • Seizure due to low blood sugar 6%
  • Flu 4%
  • Swelling in the arms and legs 8%
  • Joint pain 6%
  • High blood pressure 4%
  • Allergic reactions 4%
More Apidra side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Low blood sugar 3%
  • Constipation 3%
  • Nausea 3%
  • Headache 2%
More Glucotrol side effects »
How it works
ApidraGlucotrol
Apidra (insulin glulisine) is an insulin that controls your blood sugar by turning the sugars you eat into energy or storing it in your body for future use.Glucotrol (glipizide) stimulates your body to release insulin and lower blood sugar.
Type of medication
ApidraGlucotrol
Prescription onlyPrescription only
Available as
ApidraGlucotrol
  • Injection
  • Pill
  • Extended release pill
Used for
ApidraGlucotrol
Risk factors for serious side effects
ApidraGlucotrol
  • Changes in diet and exercise
  • Drinking alcohol
  • Taking other medications for diabetes
  • Over age 65
  • Liver or kidney problems
Detailed Apidra (insulin glulisine) risks & warnings »
  • Skipping meals or having inconsistent meal times
  • Drinking alcohol
  • Using other blood sugar-lowering medicine
  • People age 60 or older
  • Those with kidney and/or liver problems
Detailed Glucotrol (glipizide) risks & warnings »
Pregnancy
Alcohol
ApidraGlucotrol
No alcohol related info.
  • Avoid drinking alcohol while taking Glucotrol (glipizide).
Food
ApidraGlucotrol
  • Apidra (insulin glulisine) has to be injected with every meal.
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
Kidneys and liver
ApidraGlucotrol
  • Your doctor might have to check your kidneys and liver regularly if you've had kidney or liver problems in the past.
No kidneys and liver related info.
Weight
ApidraGlucotrol
No weight related info.
  • Can cause mild weight gain of 2-3lb.
Upsides and benefits
ApidraGlucotrol
  • Apidra (insulin glulisine) starts working in as soon as 15 minutes.
  • Programs are available to lower your copay. Talk to your doctor or pharmacist.
  • Can be used in children 4 years of age and older.
  • Can be used in people over 65.
  • Lowers A1c levels by 1-2%.
  • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Okay to use by people with kidney problems.
  • Available as a generic form and is relatively cheap.
Downsides and risks
ApidraGlucotrol
  • Your doctor might have to check your kidneys and liver regularly if you've had kidney or liver problems in the past.
  • Apidra (insulin glulisine) has to be injected with every meal.
  • Only available as a brand name, so Apidra (insulin glulisine) can be expensive.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2-3lb.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
Tips from our pharmacists for people taking the medication
ApidraGlucotrol
  • Starts working within 10 to 30 minutes, and lasts for up to 5 hours.
  • Take Apidra (insulin glulisine) 15 minutes before a meal or within 20 minutes after starting a meal.
  • Don't mix Apidra (insulin glulisine) for under the skin injection with any other insulin except Novolin N or Humulin N. Don't mix Apidra (insulin glulisine) with any other insulin if you're using an insulin pump.
  • Don't use Apidra (insulin glulisine) if it looks cloudy or changes color, it's leaking or if there are particles in it.
  • Change the area where you inject Apidra (insulin glulisine) every time.
  • Keep all unopened vials or pens of Apidra (insulin glulisine) in the fridge until you're ready to use it. You can keep opened vials and pens at room temperature, but throw it away after 28 days.
  • Take the medicine 30 minutes before eating, usually before your first big meal of the day.
  • Avoid drinking alcohol while taking Glucotrol (glipizide).
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
  • Check your blood sugar regularly.
  • Glucotrol (glipizide) can cause dizziness so avoid activities that require coordination until you know how your body can handle the medicine.
Learn more
More about ApidraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Apidra (insulin glulisine)?
Worth itNot sureNot worth it
More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it