Compare Apidra vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Apidra
(insulin glulisine)

Diabeta
(glyburide)

Controls blood sugar. Apidra (insulin glulisine) is an insulin that controls blood sugar during your meals, but you'll still have to follow your doctor's diet and exercise plan.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
Reviews & ratings
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Have you used Apidra (insulin glulisine)?
Worth itNot sureNot worth it
Reviews for glyburide
45%
+55% better vs. Apidra
34%
+66% better vs. Apidra
21%
+21% better vs. Apidra
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Side effects
Apidraglyburide
  • Common cold 11%
  • Upper respiratory tract infection 8%
  • Low blood sugar 7%
  • Headache 7%
  • Seizure due to low blood sugar 6%
  • Flu 4%
  • Swelling in the arms and legs 8%
  • Joint pain 6%
  • High blood pressure 4%
  • Allergic reactions 4%
More Apidra side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
How it works
Apidraglyburide
Apidra (insulin glulisine) is an insulin that controls your blood sugar by turning the sugars you eat into energy or storing it in your body for future use.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.
Type of medication
Apidraglyburide
Prescription onlyPrescription only
Available as
Apidraglyburide
  • Injection
  • Pill
Used for
Apidraglyburide
Risk factors for serious side effects
Apidraglyburide
  • Changes in diet and exercise
  • Drinking alcohol
  • Taking other medications for diabetes
  • Over age 65
  • Liver or kidney problems
Detailed Apidra (insulin glulisine) risks & warnings »
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
Apidraglyburide
No alcohol related info.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
Food
Apidraglyburide
  • Apidra (insulin glulisine) has to be injected with every meal.
  • Eat well-balanced meals to avoid low blood sugar.
Kidneys and liver
Apidraglyburide
  • Your doctor might have to check your kidneys and liver regularly if you've had kidney or liver problems in the past.
  • Not ideal for elderly or those with poor kidney function.
Weight
Apidraglyburide
No weight related info.
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause weight gain (about 2 to 3 pounds).
Upsides and benefits
Apidraglyburide
  • Apidra (insulin glulisine) starts working in as soon as 15 minutes.
  • Programs are available to lower your copay. Talk to your doctor or pharmacist.
  • Can be used in children 4 years of age and older.
  • Can be used in people over 65.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides and risks
Apidraglyburide
  • Your doctor might have to check your kidneys and liver regularly if you've had kidney or liver problems in the past.
  • Apidra (insulin glulisine) has to be injected with every meal.
  • Only available as a brand name, so Apidra (insulin glulisine) can be expensive.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Tips from our pharmacists for people taking the medication
Apidraglyburide
  • Starts working within 10 to 30 minutes, and lasts for up to 5 hours.
  • Take Apidra (insulin glulisine) 15 minutes before a meal or within 20 minutes after starting a meal.
  • Don't mix Apidra (insulin glulisine) for under the skin injection with any other insulin except Novolin N or Humulin N. Don't mix Apidra (insulin glulisine) with any other insulin if you're using an insulin pump.
  • Don't use Apidra (insulin glulisine) if it looks cloudy or changes color, it's leaking or if there are particles in it.
  • Change the area where you inject Apidra (insulin glulisine) every time.
  • Keep all unopened vials or pens of Apidra (insulin glulisine) in the fridge until you're ready to use it. You can keep opened vials and pens at room temperature, but throw it away after 28 days.
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
Learn more
More about ApidraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Apidra (insulin glulisine)?
Worth itNot sureNot worth it
More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it