Compare Apidra vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta (glyburide)

Prescription only
Controls blood sugar.

Apidra (insulin glulisine) is an insulin that controls blood sugar during your meals, but you'll still have to follow your doctor's diet and exercise plan.

Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

3.3/ 5 average rating with 110 reviewsforglyburide
Upsides
  • Apidra (insulin glulisine) starts working in as soon as 15 minutes.
  • Programs are available to lower your copay. Talk to your doctor or pharmacist.
  • Can be used in people over 65 and children 4 years of age and older.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides
  • Your doctor might have to check your kidneys and liver regularly if you've had kidney or liver problems in the past.
  • Since Apidra (insulin glulisine) is an injectable, it might not be a good treatment option for people who are afraid of needles.
  • Only available as a brand name, so Apidra (insulin glulisine) can be expensive.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Used for
Dosage forms
  • Injection
  • Pill
Price
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Reviews
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110 reviews so far
45%
saidit'sworth it
34%
saiditworked well
21%
saidit'sa big hassle

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Side effects
1possible side effects
  • Common cold
    11%
See more detailed side effects
The Diabeta (glyburide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Sharing of pen and needles
  • Low blood sugar
    • Changes in diet and exercise
    • Drinking alcohol
    • Taking other medications for diabetes
    • Over age 65
    • Liver or kidney problems
  • Severe allergic reactions
  • Low blood potassium levels
    • Taking laxatives
    • Taking medications that increase urination
  • Mixing of insulins
  • Fluid buildup
    • Taking Avandia or Actos
See more detailed risks and warnings
  • Low blood sugar
    • Over age 65
    • Kidney problems
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
  • Severe allergic reactions
    • History of sulfa allergies
See more detailed risks and warnings