Compare Apidra vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(Insulin Glulisine)

(Sitagliptin / Metformin)

Coming soon.Lowers blood sugar. Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.
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Reviews & ratings
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Reviews for Janumet (Sitagliptin / Metformin)
56% vs. Apidra (Insulin Glulisine)
64% vs. Apidra (Insulin Glulisine)
16% vs. Apidra (Insulin Glulisine)
Side effects

We haven’t found good data for Apidra side effects.

FDA side effect reports for Apidra »
  • Diarrhea 4%
  • Nausea 4%
  • Headache 3%
  • Abdominal pain 1%
  • Ear, nose, or throat infection 1%
More Janumet side effects »
How it works
Coming soon.Janumet is an antidiabetic combination medicine. Metformin lowers the amount of sugar your body produces, and sitagliptin helps your body release more insulin.
Type of medication
Coming soon.
DPP-4 inhibitor
Prescription only
Available as
  • Injection
  • Pill
  • Extended release
Used for (click to learn more)
  • Diabetes mellitus type 1 Diabetes mellitus type 2
Risk factors for serious side effects
Coming soon.
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Contrast dye for procedure
  • Surgery
  • Alcohol use
        Detailed Janumet (Sitagliptin / Metformin) risks & warnings »
        Pregnancy category
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        No specific alcohol-related info.No specific alcohol-related info.
        No specific food-related info.
        • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
        Kidneys and liver
        No specific kidneys and liver-related info.
        • People with poor kidney function can't use it.
        • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
        No specific sex-related info.No specific sex-related info.
        No specific sleep-related info.No specific sleep-related info.
        No specific weight-related info.
        • Doesn't cause weight gain or low blood sugar.
        Upsides and benefits
        Coming soon.
        • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
        • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Doesn't cause weight gain or low blood sugar.
        • You don't have to check your blood sugar every day with this medicine.
        Downsides and risks
        Coming soon.
        • Likely expensive since there's no generic version available.
        • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
        • People with poor kidney function can't use it.
        • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
        • Might raise the risk of problems with your pancreas.
        Tips from our pharmacists for people taking the medication
        Coming soon.
        • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
        • May cause headaches and cold-like symptoms.
        • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
        • Can be expensive depending on insurance coverage.
        • Check your blood sugar regularly.
        Learn more
        More about ApidraSide effectsReviews & ratingsFDA package insert
        More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert