Compare Apidra vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Apidra
(insulin glulisine)

Janumet
(sitagliptin / metformin)

Controls blood sugar. Apidra (insulin glulisine) is an insulin that controls blood sugar during your meals, but you'll still have to follow your doctor's diet and exercise plan.Lowers your blood sugar. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.
Reviews & ratings
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Have you used Apidra (insulin glulisine)?
Worth itNot sureNot worth it
Reviews for Janumet
46%
+54% better vs. Apidra
38%
+62% better vs. Apidra
15%
+15% better vs. Apidra
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
Side effects
ApidraJanumet
  • Common cold 11%
  • Upper respiratory tract infection 8%
  • Low blood sugar 7%
  • Headache 7%
  • Seizure due to low blood sugar 6%
  • Flu 4%
  • Swelling in the arms and legs 8%
  • Joint pain 6%
  • High blood pressure 4%
  • Allergic reactions 4%
More Apidra side effects »
  • Low blood sugar 15%
  • Diarrhea 4%
  • Upper respiratory tract infection 1%
  • Headache 3%
More Janumet side effects »
How it works
ApidraJanumet
Apidra (insulin glulisine) is an insulin that controls your blood sugar by turning the sugars you eat into energy or storing it in your body for future use.Janumet (sitagliptin / metformin) is a combination of two anti-diabetic medicines. Metformin lowers the amount of sugar your body produces, and sitagliptin enhances the release of insulin.
Type of medication
ApidraJanumet
Prescription onlyPrescription only
Available as
ApidraJanumet
  • Injection
  • Pill
  • Extended release
Used for
ApidraJanumet
Risk factors for serious side effects
ApidraJanumet
  • Changes in diet and exercise
  • Drinking alcohol
  • Taking other medications for diabetes
  • Over age 65
  • Liver or kidney problems
Detailed Apidra (insulin glulisine) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Janumet (sitagliptin / metformin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
ApidraJanumet
  • Apidra (insulin glulisine) has to be injected with every meal.
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
Kidneys and liver
ApidraJanumet
  • Your doctor might have to check your kidneys and liver regularly if you've had kidney or liver problems in the past.
  • Not appropriate for those with poor kidney function.
Upsides and benefits
ApidraJanumet
  • Apidra (insulin glulisine) starts working in as soon as 15 minutes.
  • Programs are available to lower your copay. Talk to your doctor or pharmacist.
  • Can be used in children 4 years of age and older.
  • Can be used in people over 65.
  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
Downsides and risks
ApidraJanumet
  • Your doctor might have to check your kidneys and liver regularly if you've had kidney or liver problems in the past.
  • Apidra (insulin glulisine) has to be injected with every meal.
  • Only available as a brand name, so Apidra (insulin glulisine) can be expensive.
  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
Tips from our pharmacists for people taking the medication
ApidraJanumet
  • Starts working within 10 to 30 minutes, and lasts for up to 5 hours.
  • Take Apidra (insulin glulisine) 15 minutes before a meal or within 20 minutes after starting a meal.
  • Don't mix Apidra (insulin glulisine) for under the skin injection with any other insulin except Novolin N or Humulin N. Don't mix Apidra (insulin glulisine) with any other insulin if you're using an insulin pump.
  • Don't use Apidra (insulin glulisine) if it looks cloudy or changes color, it's leaking or if there are particles in it.
  • Change the area where you inject Apidra (insulin glulisine) every time.
  • Keep all unopened vials or pens of Apidra (insulin glulisine) in the fridge until you're ready to use it. You can keep opened vials and pens at room temperature, but throw it away after 28 days.
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • May cause headaches and cold-like symptoms.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Can be expensive depending on insurance coverage.
  • Check your blood sugar regularly.
Learn more
More about ApidraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Apidra (insulin glulisine)?
Worth itNot sureNot worth it
More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it