Compare Apidra vs. metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Apidra (insulin glulisine)

Prescription only

Glucophage (metformin)

Prescription only
Controls blood sugar.

Apidra (insulin glulisine) is an insulin that controls blood sugar during your meals, but you'll still have to follow your doctor's diet and exercise plan.

Lowers blood sugar.

Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.

5.0/ 7 average rating with 938 reviewsformetformin
Upsides
  • Apidra (insulin glulisine) starts working in as soon as 15 minutes.
  • Programs are available to lower your copay. Talk to your doctor or pharmacist.
  • Can be used in people over 65 and children 4 years of age and older.
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
Downsides
  • Your doctor might have to check your kidneys and liver regularly if you've had kidney or liver problems in the past.
  • Since Apidra (insulin glulisine) is an injectable, it might not be a good treatment option for people who are afraid of needles.
  • Only available as a brand name, so Apidra (insulin glulisine) can be expensive.
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
Used for
Dosage forms
  • Injection
  • Pill
  • Extended release pill
  • Liquid
Price
Lowest price near you
$511.84
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Lowest price near you
$4
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Reviews
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938 
65%
think this treatment is worth it
46%
think this treatment works well
16%
think this treatment is a hassle

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Side effects
1possible side effects
  • Common cold
    11%
See more detailed side effects
7possible side effects
  • Diarrhea
    53%
  • Nausea/vomiting
    26%
  • Gas
    12%
  • Weakness
    9%
  • Indigestion
    7%
  • Stomach pain
    6%
  • Headache
    6%
See more detailed side effects
Risks and warnings
  • Low blood sugar

    Changes in diet and exercise

    ...and 4 more risk factors

  • Low blood potassium levels

    Taking laxatives

    ...and 1 more risk factors

  • Fluid buildup

    Taking Avandia or Actos

See more detailed risks and warnings
  • Excess lactic acid in the blood

    Kidney problems

    ...and 5 more risk factors

See more detailed risks and warnings