Compare Apokyn vs. Azilect

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Apokyn
(apomorphine)

Azilect
(rasagiline)

Helps you move around. Apokyn (apomorphine) is good for treating the "off" episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness.Treats Parkinson's disease. Azilect (rasagiline) is one of the recommended medicines to treat Parkinson's disease. It is now available in generic, which makes it more affordable for people without insurance.
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Prices and coupon for 20 (3ml of 30mg/3ml) cartridges of apomorphine
Coupons for
Prices and coupon for 30 (1mg) tablets of rasagiline
Reviews & ratings
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Have you used Apokyn (apomorphine)?
Worth itNot sureNot worth it

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Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it
Side effects
ApokynAzilect
  • Yawning 40%
  • Movement problems 24%
  • Drowsiness or sleepiness 35%
  • Nausea or vomiting 19%
  • Dizziness 20%
  • Runny nose 20%
  • Chest pain 15%
  • Hallucinations 10%
  • Swelling in arms and legs 10%
More Apokyn side effects »
  • Difficulty controlling movement 8%
  • Headache 2%
  • Accidental injury 7%
  • Nausea 4%
  • Falls 3%
  • Low blood pressure 6%
  • Constipation 4%
  • Weight loss 6%
  • Joint pain 4%
  • Diarrhea 3%
More Azilect side effects »
How it works
ApokynAzilect
Apokyn (apomorphine) is a non-ergoline dopamine agonist. Apokyn (apomorphine) allows you to move around more freely by stimulating the brain's ability to use dopamine, which is important for movement.Azilect (rasagiline) is a monoamine oxidase inhibitor. It increases the amount of dopamine in the brain, which helps those with Parkinson's disease gain better control their movements.
Type of medication
ApokynAzilect
Prescription only
Prescription only
Available as
ApokynAzilect
  • Injection
  • Pill
Used for
ApokynAzilect
Risk factors for serious side effects
ApokynAzilect
    • Taking antipsychotic medicines
    • Taking other medicines for Parkinson's disease
    • History of heart disease or stroke
        Detailed Apokyn (apomorphine) risks & warnings »
        • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
        • Tricyclic antidepressants
        • Fentanyl
        • Tramadol
        • Buspirone
        • ADHD medicines
        • Triptans
        • dextromethorphan
        • pseudoephedrine
        • Taking other medicines for Parkinson's disease
          • Taking other medicines for Parkinson's disease
          • Taking other medicines for Parkinson's disease
          Detailed Azilect (rasagiline) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Sleep
          ApokynAzilect
          • Apokyn (apomorphine) can make you sleepy or fall asleep without warning. Don't drive or do anything that requires concentration until you know how it affects you.
          • Apokyn (apomorphine) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires your full concentration until you know how Apokyn (apomorphine) affects you. You're more at risk if you're taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
          No sleep related info.
          Upsides and benefits
          ApokynAzilect
          • Preferred drug according to the guidelines to treat the "off" periods or inability to control movements well that's associated with Parkinson's.
          • People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines.
          • Azilect (rasagiline) is one of the go-to medicines for Parkinson's disease. It can be used in early and late stages of the disease.
          • Taking Azilect (rasagiline) by itself can help slow down Parkinson's disease, but it works better when it's given with other medicines.
          • Azilect (rasagiline) is available as generic as well as brand name, so there are usually lower out-of-pocket costs for you with insurance.
          Downsides and risks
          ApokynAzilect
          • Can cause vomiting and sudden sleepiness. Your doctor will have to give you a medicine to stop the vomiting from happening.
          • Apokyn (apomorphine) should only be used if you have an "off" period of moving around. You should keep using your other medicines for your Parkinson's.
          • Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams.
          • Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. Talk to your doctor if you want to stop taking this medicine.
          • It can cause unusual cravings and changes in behavior in some people.
          Tips from our pharmacists for people taking the medication
          ApokynAzilect
          • Apokyn (apomorphine) can cause nausea, so your doctor will give you medicine to help stop that and vomiting.
          • Your doctor will tell you how much Apokyn (apomorphine) you will inject. This is given in milliliters. Turn the pen so that the correct dose is given.
          • Apokyn (apomorphine) can make you sleepy or fall asleep without warning. Don't drive or do anything that requires concentration until you know how it affects you.
          • Always change where you inject Apokyn (apomorphine) and always use a fresh needle every time. This will make injecting safer and less painful.
          • If the liquid inside the Apokyn (apomorphine) cartridge does not look clear and colorless, don't use it. Use a new cartridge or call your pharmacy.
          • Can cause you to feel faint, especially if you get up after sitting or lying down for a while. Be careful moving around after you use Apokyn (apomorphine) so you don't fall.
          • Azilect (rasagiline) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
          • Watch how much cheese, soy sauce or smoked meats you eat. Eating too much of these foods while on Azilect (rasagiline) can cause an unsafe rise in blood pressure.
          • Azilect (rasagiline) can make you dizzy or lightheaded, especially when you suddenly stand up from sitting or laying down.
          • Don't stop taking Azilect (rasagiline) without talking to your doctor first. Stopping it suddenly can cause confusion, stiff muscles and a high fever.
          • Azilect (rasagiline) can prevent many medicines from working properly. Check with your doctor or pharmacist if the way you take your other medicines needs to be changed.
          Learn more
          More about ApokynSide effectsAlternativesFDA package insert
          Have you used Apokyn (apomorphine)?
          Worth itNot sureNot worth it
          More about AzilectSide effectsAlternativesFDA package insert
          Have you used Azilect (rasagiline)?
          Worth itNot sureNot worth it