Compare Apokyn vs. carbidopa / levodopa / entacapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Apokyn
(apomorphine)

Stalevo
(carbidopa / levodopa / entacapone)

Helps you move around. Apokyn (apomorphine) is good for treating the "off" episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness.Treats Parkinson's disease. Stalevo (carbidopa / levodopa / entacapone) is a good choice for Parkinson's disease, especially when carbidopa/levodopa starts losing its effect.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Apokyn
Best available price for 1 (3ml of 30mg/3ml) cartridge of apomorphine
Best available price for 120 (150mg) tablets of carbidopa / levodopa / entacapone
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Apokyn (apomorphine)
Not enough review data. Review it!
of people (All ages) say Apokyn (apomorphine) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Apokyn (apomorphine)?
Worth itNot sureNot worth it
Reviews for Stalevo (carbidopa / levodopa / entacapone)
Not enough review data. Review it!
Same vs. Apokyn (apomorphine)
Not enough review data. Review it!
Same vs. Apokyn (apomorphine)
Not enough review data. Review it!
Same vs. Apokyn (apomorphine)
Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it
Side effects
Apokyncarbidopa / levodopa / entacapone
  • Yawning 40%
  • Movement problems 24%
  • Drowsiness or sleepiness 35%
  • Nausea or vomiting 19%
  • Dizziness 20%
  • Runny nose 20%
  • Chest pain 15%
  • Hallucinations 10%
  • Swelling in arms and legs 10%
More Apokyn side effects »
  • Difficulty controlling movements 10%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Discolored urine 10%
  • Muscle rigidity 1%
  • Abdominal pain 4%
  • Dizziness 2%
  • Fatigue 2%
  • Constipation 2%
More carbidopa / levodopa / entacapone side effects »
How it works
Apokyncarbidopa / levodopa / entacapone
Apokyn (apomorphine) is a non-ergoline dopamine agonist. Apokyn (apomorphine) allows you to move around more freely by stimulating the brain's ability to use dopamine, which is important for movement.Stalevo (carbidopa / levodopa / entacapone) is a combination of carbidopa, levodopa, and entacapone. Entacopone and carbidopa prevent breakdown of levodopa in the body so that levodopa can then enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
Apokyncarbidopa / levodopa / entacapone
Prescription only
Prescription only
Available as
Apokyncarbidopa / levodopa / entacapone
  • Injection
  • Pill
Used for
Apokyncarbidopa / levodopa / entacapone
Risk factors for serious side effects
Apokyncarbidopa / levodopa / entacapone
  • Taking antipsychotic medicines
  • Taking other medicines for Parkinson's disease
  • History of heart disease or stroke
Detailed Apokyn (apomorphine) risks & warnings »
  • History of stomach ulcers
Detailed Stalevo (carbidopa / levodopa / entacapone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Sleep
Apokyncarbidopa / levodopa / entacapone
  • Apokyn (apomorphine) can make you sleepy or fall asleep without warning. Don't drive or do anything that requires concentration until you know how it affects you.
  • Apokyn (apomorphine) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires your full concentration until you know how Apokyn (apomorphine) affects you. You're more at risk if you're taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
No sleep related info.
Upsides and benefits
Apokyncarbidopa / levodopa / entacapone
  • Preferred drug according to the guidelines to treat the "off" periods or inability to control movements well that's associated with Parkinson's.
  • People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines.
  • It combines three medicines into one pill so you don't have to take so many pills daily.
  • Stalevo (carbidopa / levodopa / entacapone) is available as a generic.
Downsides and risks
Apokyncarbidopa / levodopa / entacapone
  • Can cause vomiting and sudden sleepiness. Your doctor will have to give you a medicine to stop the vomiting from happening.
  • Apokyn (apomorphine) should only be used if you have an "off" period of moving around. You should keep using your other medicines for your Parkinson's.
  • Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams.
  • Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. Talk to your doctor if you want to stop taking this medicine.
  • You would first start by taking Stalevo (carbidopa / levodopa / entacapone) as two different pills, carbidopa/levodopa and entacapone, before you get switched over to Stalevo (carbidopa / levodopa / entacapone).
  • It's less customizable since there are only a few fixed combinations available.
Tips from our pharmacists for people taking the medication
Apokyncarbidopa / levodopa / entacapone
  • Apokyn (apomorphine) can cause nausea, so your doctor will give you medicine to help stop that and vomiting.
  • Your doctor will tell you how much Apokyn (apomorphine) you will inject. This is given in milliliters. Turn the pen so that the correct dose is given.
  • Apokyn (apomorphine) can make you sleepy or fall asleep without warning. Don't drive or do anything that requires concentration until you know how it affects you.
  • Always change where you inject Apokyn (apomorphine) and always use a fresh needle every time. This will make injecting safer and less painful.
  • If the liquid inside the Apokyn (apomorphine) cartridge does not look clear and colorless, don't use it. Use a new cartridge or call your pharmacy.
  • Can cause you to feel faint, especially if you get up after sitting or lying down for a while. Be careful moving around after you use Apokyn (apomorphine) so you don't fall.
  • Stalevo (carbidopa / levodopa / entacapone) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Stalevo (carbidopa / levodopa / entacapone).
  • Take Stalevo (carbidopa / levodopa / entacapone) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
  • Stalevo (carbidopa / levodopa / entacapone) may cause unusual cravings in some people.
Learn more
More about ApokynSide effectsAlternativesFDA package insert
Have you used Apokyn (apomorphine)?
Worth itNot sureNot worth it
More about carbidopa / levodopa / entacaponeSide effectsAlternativesFDA package insert
Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it