Compare Apokyn vs. Duopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Apokyn (apomorphine)

Prescription only
Helps you move around.

Apokyn (apomorphine) is good for treating the "off" episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness.

Treats advanced stages of Parkinson's disease.

Duopa (carbidopa / levodopa) pumps carbidopa/levodopa into your body throughout the day. It is reserved for advanced Parkinson's disease when your symptoms become more frequent than the dosing of your tablets.

Upsides
  • Preferred drug according to the guidelines to treat the "off" periods or inability to control movements well that's associated with Parkinson's.
  • People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines.
  • Duopa (carbidopa / levodopa) allows you to have better control of your symptoms than oral tablets, especially in later stages of Parkinson's disease.
Downsides
  • Can cause vomiting and sudden sleepiness. Your doctor will have to give you a medicine to stop the vomiting from happening.
  • Apokyn (apomorphine) should only be used if you have an "off" period of moving around. You should keep using your other medicines for your Parkinson's.
  • Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams.
  • Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. Talk to your doctor if you want to stop taking this medicine.
  • Given via pump so you'll need to have a procedure to attach the pump to your body.
  • You'll need to take good care of the pump so that it doesn't get disconnected or infected.
  • Duopa (carbidopa / levodopa) only lasts for 16 hours. You may need to take an extra dose of carbidopa/levodopa as tablet for nighttime control.
  • You need to keep Duopa (carbidopa / levodopa) in a fridge, but it should sit at room temperature 20 minutes before infusion.
Used for
Dosage forms
  • Injection
  • Liquid
Price
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Reviews
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Side effects
9possible side effects
  • Yawning
    40%
  • Movement problems
    35%
  • Drowsiness or sleepiness
    35%
  • Nausea or vomiting
    30%
  • Dizziness
    20%
  • Runny nose
    20%
  • Chest pain
    15%
  • Hallucinations
    10%
  • Swelling in arms and legs
    10%
See more detailed side effects
26possible side effects
  • Problems with J-tube
    56%
  • Nausea
    30%
  • Constipation
    22%
  • Redness and swelling at the J-tube site
    19%
  • Difficulty controlling movements
    14%
  • Depression
    11%
  • Discharge at the J-tube site
    11%
  • Swelling in the arms and legs
    8%
  • High blood pressure
    8%
  • Flu and cold
    8%
  • Sore throat
    8%
  • Collapsed lung
    8%
  • Confusion
    8%
  • Anxiety
    8%
  • Dizziness
    8%
  • Hiatal hernia
    8%
  • Intestinal blockage
    5%
  • Sleep problems
    5%
  • Fever
    5%
  • Scar tissue
    5%
  • Rash
    5%
  • Urinary tract infection
    5%
  • Hallucinations
    5%
  • Psychotic disorder
    5%
  • Diarrhea
    5%
  • Indigestion
    5%
See more detailed side effects
Risks and risk factors
  • Fainting
  • Hallucinations
    • Taking antipsychotic medicines
  • Falling asleep during the day
    • Taking other medicines for Parkinson's disease
  • Increased risk of heart attack or stroke
    • History of heart disease or stroke
  • Nausea and vomiting
  • Priapism
See more detailed risks and warnings
  • Stomach problems
    • Surgery to place the J-tube
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • High fever and confusion
    • Stopping Duopa (carbidopa / levodopa) suddenly
  • Changes in behavior
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
See more detailed risks and warnings