Compare Apokyn vs. Mirapex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Apokyn (apomorphine)

Prescription only

Mirapex (Pramipexole)

Prescription only
Helps you move around.

Apokyn (apomorphine) is good for treating the "off" episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness.

Helps with movement problems.

Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.

Upsides
  • Preferred drug according to the guidelines to treat the "off" periods or inability to control movements well that's associated with Parkinson's.
  • People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines.
  • In studies, Mirapex (Pramipexole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
  • Mirapex (Pramipexole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
  • Is effective for treating restless leg syndrome.
  • Available in a short-acting and a long-acting form.
Downsides
  • Can cause vomiting and sudden sleepiness. Your doctor will have to give you a medicine to stop the vomiting from happening.
  • Apokyn (apomorphine) should only be used if you have an "off" period of moving around. You should keep using your other medicines for your Parkinson's.
  • Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams.
  • Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. Talk to your doctor if you want to stop taking this medicine.
  • Mirapex (Pramipexole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
  • Mirapex (Pramipexole) can cause hallucinations in older people.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
  • You can't suddenly stop taking Mirapex (Pramipexole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
Used for
Dosage forms
  • Injection
  • Pill
  • Extended release
Price
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Reviews
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Side effects
9possible side effects
  • Yawning
    40%
  • Movement problems
    35%
  • Drowsiness or sleepiness
    35%
  • Nausea or vomiting
    30%
  • Dizziness
    20%
  • Runny nose
    20%
  • Chest pain
    15%
  • Hallucinations
    10%
  • Swelling in arms and legs
    10%
See more detailed side effects
45possible side effects
  • Postural hypotension
    53%
  • Dyskinesia
    47%
  • Extrapyramidal syndrome
    28%
  • Insomnia
    27%
  • Dizziness
    26%
  • Accidental injury
    17%
  • Hallucinations
    17%
  • Any side effect
    12%
  • Dream abnormalities
    11%
  • Nausea
    11%
  • Asthenia
    10%
  • Constipation
    10%
  • Confusion
    10%
  • Somnolence
    9%
  • Hallucinations, including visual, auditory and mixed
    9%
  • Dystonia
    8%
  • Dry mouth
    7%
  • Gait abnormalities
    7%
  • Hypertonia
    7%
  • Headache
    7%
  • Amnesia
    6%
  • Urinary frequency
    6%
  • Anorexia
    5%
  • General edema
    4%
  • Dyspnea
    4%
  • Accommodation abnormalities
    4%
  • Urinary tract infection
    4%
  • Chest pain
    3%
  • Malaise
    3%
  • Arthritis
    3%
  • Akathisia
    3%
  • Thinking abnormalities
    3%
  • Rhinitis
    3%
  • Vision abnormalities
    3%
  • Dizziness (postural)
    3%
  • Back pain
    3%
  • Peripheral edema
    2%
  • Twitching
    2%
  • Bursitis
    2%
  • Paranoid reaction
    2%
  • Pneumonia
    2%
  • Skin disorders
    2%
  • Urinary incontinence
    2%
  • Salivary hypersecretion
    2%
  • Diarrhea
    2%
See more detailed side effects
Risks and risk factors
  • Fainting
  • Hallucinations
    • Taking antipsychotic medicines
  • Falling asleep during the day
    • Taking other medicines for Parkinson's disease
  • Increased risk of heart attack or stroke
    • History of heart disease or stroke
  • Nausea and vomiting
  • Priapism
See more detailed risks and warnings
  • Impulse control problems
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Low blood pressure
    • Taking blood pressure-lowering medicines
  • Worsening kidney function
    • Current kidney problems
  • Skin cancer
    • Parkinson's disease
  • Hallucinations
    • Age 65 years or older
See more detailed risks and warnings