Compare Apokyn vs. Mirapex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Apokyn
(apomorphine)

Mirapex
(Pramipexole)

Helps you move around. Apokyn (apomorphine) is good for treating the "off" episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness.Helps with movement problems. Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Apokyn (apomorphine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Mirapex (Pramipexole)?
Worth itNot sureNot worth it
Side effects
ApokynMirapex
  • Hallucinations 10%
  • Swelling in arms and legs 10%
  • Chest pain 15%
  • Dizziness 20%
  • Runny nose 20%
  • Nausea or vomiting 19%
  • Movement problems 24%
  • Drowsiness or sleepiness 35%
  • Yawning 40%
More Apokyn side effects »
  • Dizziness 1%
  • Somnolence 2%
  • Nausea 2%
  • Hallucinations 3%
  • Any side effect 1%
  • Malaise 1%
  • Dysphagia 2%
  • Decreased weight 2%
  • Dystonia 1%
More Mirapex side effects »
How it works
ApokynMirapex
Apokyn (apomorphine) is a non-ergoline dopamine agonist. Apokyn (apomorphine) allows you to move around more freely by stimulating the brain's ability to use dopamine, which is important for movement.Mirapex (Pramipexole) is a dopamine agonist. It binds to receptors in the brain and helps improve movement in people with Parkinson's disease or restless leg syndrome.
Type of medication
ApokynMirapex
Prescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
ApokynMirapex
  • Injection
  • Pill
  • Extended release
Used for
ApokynMirapex
Risk factors for serious side effects
ApokynMirapex
  • Taking antipsychotic medicines
  • Taking other medicines for Parkinson's disease
  • History of heart disease or stroke
Detailed Apokyn (apomorphine) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Taking blood pressure-lowering medicines
  • Current kidney problems
  • Parkinson's disease
Detailed Mirapex (Pramipexole) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
ApokynMirapex
No food related info.
  • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
Kidneys and liver
ApokynMirapex
No kidneys and liver related info.
  • Mirapex (Pramipexole) is processed by the kidney. If you have kidney problems, talk to your doctor because you may need a different dose.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
Sleep
ApokynMirapex
  • Apokyn (apomorphine) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires your full concentration until you know how Apokyn (apomorphine) affects you. You're more at risk if you're taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
  • Apokyn (apomorphine) can make you sleepy or fall asleep without warning. Don't drive or do anything that requires concentration until you know how it affects you.
No sleep related info.
Upsides and benefits
ApokynMirapex
  • Preferred drug according to the guidelines to treat the "off" periods or inability to control movements well that's associated with Parkinson's.
  • People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines.
  • In studies, Mirapex (Pramipexole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
  • Mirapex (Pramipexole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
  • Is effective for treating restless leg syndrome.
  • Available in a short-acting and a long-acting form.
Downsides and risks
ApokynMirapex
  • Can cause vomiting and sudden sleepiness. Your doctor will have to give you a medicine to stop the vomiting from happening.
  • Apokyn (apomorphine) should only be used if you have an "off" period of moving around. You should keep using your other medicines for your Parkinson's.
  • Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams.
  • Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. Talk to your doctor if you want to stop taking this medicine.
  • Mirapex (Pramipexole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
  • Mirapex (Pramipexole) can cause hallucinations in older people.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
  • You can't suddenly stop taking Mirapex (Pramipexole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
Tips from our pharmacists for people taking the medication
ApokynMirapex
  • Apokyn (apomorphine) can cause nausea, so your doctor will give you medicine to help stop that and vomiting.
  • Your doctor will tell you how much Apokyn (apomorphine) you will inject. This is given in milliliters. Turn the pen so that the correct dose is given.
  • Apokyn (apomorphine) can make you sleepy or fall asleep without warning. Don't drive or do anything that requires concentration until you know how it affects you.
  • Always change where you inject Apokyn (apomorphine) and always use a fresh needle every time. This will make injecting safer and less painful.
  • If the liquid inside the Apokyn (apomorphine) cartridge does not look clear and colorless, don't use it. Use a new cartridge or call your pharmacy.
  • Can cause you to feel faint, especially if you get up after sitting or lying down for a while. Be careful moving around after you use Apokyn (apomorphine) so you don't fall.
  • You should start Mirapex (Pramipexole) at a low dose and your doctor will raise the dose slowly. This will help lower your risk of side effects, such as drowsiness and low blood pressure.
  • Can cause intense urges and compulsive behaviors that are hard to control, such as binge eating, gambling, and sexual urges. Talk to your doctor right away if you have any of these feelings.
  • You can suddenly fall asleep without warning while on this medicine. Don't perform any tasks that require mental alertness, like driving, or drinking alcohol until you know how Mirapex (Pramipexole) affects you. Let your doctor know if you have a history of sleep problems.
  • Take Mirapex (Pramipexole) 2 to 3 hours before bedtime for restless leg syndrome.
  • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
Learn more
More about ApokynSide effectsAlternativesFDA package insert
Have you used Apokyn (apomorphine)?
Worth itNot sureNot worth it
More about MirapexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Mirapex (Pramipexole)?
Worth itNot sureNot worth it