Compare Apokyn vs. Rytary

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Apokyn (apomorphine)

Prescription only
Helps you move around.

Apokyn (apomorphine) is good for treating the "off" episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness.

Treats Parkinson's disease.

Rytary (carbidopa / levodopa) can be used to treat Parkinson's disease, but it can be expensive.

Upsides
  • Preferred drug according to the guidelines to treat the "off" periods or inability to control movements well that's associated with Parkinson's.
  • People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines.
  • Rytary (carbidopa / levodopa) comes in 4 different strengths.
  • If you have private prescription insurance, there are programs to make Rytary (carbidopa / levodopa) more affordable.
Downsides
  • Can cause vomiting and sudden sleepiness. Your doctor will have to give you a medicine to stop the vomiting from happening.
  • Apokyn (apomorphine) should only be used if you have an "off" period of moving around. You should keep using your other medicines for your Parkinson's.
  • Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams.
  • Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. Talk to your doctor if you want to stop taking this medicine.
  • There are other forms of Rytary (carbidopa / levodopa) that are generic and much cheaper.
  • Your doctor might have to change the dose of Rytary (carbidopa / levodopa) often before they find a dose that works for you.
  • Rytary (carbidopa / levodopa) can cause uncontrollable movements to happen, but this doesn't happen for 3 to 5 years.
  • Rytary (carbidopa / levodopa) is not a cure for Parkinson's disease; it can only slow the disease down.
Used for
Dosage forms
  • Injection
  • Extended release capsule
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
9possible side effects
  • Yawning
    40%
  • Movement problems
    35%
  • Drowsiness or sleepiness
    35%
  • Nausea or vomiting
    30%
  • Dizziness
    20%
  • Runny nose
    20%
  • Chest pain
    15%
  • Hallucinations
    10%
  • Swelling in arms and legs
    10%
See more detailed side effects
11possible side effects
  • Nausea
    20%
  • Headache
    17%
  • Dizziness
    12%
  • Dry mouth
    7%
  • Trouble sleeping
    6%
  • Abnormal dreams
    5%
  • Difficulty controlling movements
    5%
  • Anxiety
    5%
  • Vomiting
    5%
  • Changes in blood pressure
    5%
  • Constipation
    2%
See more detailed side effects
Risks and risk factors
  • Fainting
  • Hallucinations
    • Taking antipsychotic medicines
  • Falling asleep during the day
    • Taking other medicines for Parkinson's disease
  • Increased risk of heart attack or stroke
    • History of heart disease or stroke
  • Nausea and vomiting
  • Priapism
See more detailed risks and warnings
  • Falling asleep during the day
    • Taking other medicines for Parkinson's disease
  • High fever and confusion
    • Stopping Rytary (carbidopa / levodopa) suddenly
  • Changes in behavior
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
  • Heart attack
    • History of heart attack
    • High risk for heart attack
See more detailed risks and warnings