Compare Apokyn vs. tolcapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Apokyn
(apomorphine)

Tasmar
(tolcapone)

Helps you move around. Apokyn (apomorphine) is good for treating the "off" episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness.Treats Parkinson's disease. Taking Tasmar (tolcapone) is the next step to control Parkinson's disease when carbidopa/levodopa don't work as well, however you might be more likely to have liver damage.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Apokyn
Best available price for 3 (3ml of 30mg/3ml) cartridges of apokyn
Coupons for tolcapone
Best available price for 60 (100mg) tablets of tolcapone
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Apokyn (apomorphine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Tasmar (tolcapone)?
Worth itNot sureNot worth it
Side effects
Apokyntolcapone
  • Yawning 40%
  • Movement problems 24%
  • Drowsiness or sleepiness 35%
  • Nausea or vomiting 19%
  • Dizziness 20%
  • Runny nose 20%
  • Chest pain 15%
  • Hallucinations 10%
  • Swelling in arms and legs 10%
More Apokyn side effects »
  • Difficulty controlling movement 22%
  • Nausea 12%
  • Sleeping problems 6%
  • Excessive dreaming 4%
  • Muscle cramps 2%
  • Loss of appetite 6%
  • Sleepiness 5%
  • Lightheadedness from standing 3%
  • Diarrhea 8%
More tolcapone side effects »
How it works
Apokyntolcapone
Apokyn (apomorphine) is a non-ergoline dopamine agonist. Apokyn (apomorphine) allows you to move around more freely by stimulating the brain's ability to use dopamine, which is important for movement.Tasmar (tolcapone) is an enzyme inhibitor that stops levodopa from being broken down. It causes higher levodopa in the brain, which relieves the symptoms of Parkinson's disease.
Type of medication
Apokyntolcapone
Prescription onlyPrescription only
Available as
Apokyntolcapone
  • Injection
  • Pill
Used for
Apokyntolcapone
Risk factors for serious side effects
Apokyntolcapone
  • Taking antipsychotic medicines
  • Taking other medicines for Parkinson's disease
  • History of heart disease or stroke
Detailed Apokyn (apomorphine) risks & warnings »
  • Liver damage
  • Taking other medicines for Parkinson's disease
  • Taking antipsychotic medicines
Detailed Tasmar (tolcapone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
Apokyntolcapone
No food related info.
  • Tasmar (tolcapone) can be taken with or without food.
Sleep
Apokyntolcapone
  • Apokyn (apomorphine) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires your full concentration until you know how Apokyn (apomorphine) affects you. You're more at risk if you're taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
  • Apokyn (apomorphine) can make you sleepy or fall asleep without warning. Don't drive or do anything that requires concentration until you know how it affects you.
No sleep related info.
Upsides and benefits
Apokyntolcapone
  • Preferred drug according to the guidelines to treat the "off" periods or inability to control movements well that's associated with Parkinson's.
  • People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines.
  • Tasmar (tolcapone) is part of the medicines used as the most common next step to control Parkinson's disease when carbidopa/levodopa doesn't work as well.
  • Tasmar (tolcapone) is available as a generic.
  • Tasmar (tolcapone) can be taken with or without food.
Downsides and risks
Apokyntolcapone
  • Can cause vomiting and sudden sleepiness. Your doctor will have to give you a medicine to stop the vomiting from happening.
  • Apokyn (apomorphine) should only be used if you have an "off" period of moving around. You should keep using your other medicines for your Parkinson's.
  • Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams.
  • Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. Talk to your doctor if you want to stop taking this medicine.
  • When you first start taking Tasmar (tolcapone), your doctor might have to change the dose a lot because of all the side effects.
  • Tasmar (tolcapone) will only slow the disease down; it is not a cure for Parkinson's disease.
  • Unlike Comtan, Tasmar (tolcapone) is more likely to damage your liver, so you might need regular blood tests for the first few months.
  • Tasmar (tolcapone) is not available as a combination pill with carbidopa/levodopa, unlike Comtan.
  • Tasmar (tolcapone) can cause dry mouth and changes in blood pressure. Changes in blood pressure can make you feel faint and more likely to fall.
Tips from our pharmacists for people taking the medication
Apokyntolcapone
  • Apokyn (apomorphine) can cause nausea, so your doctor will give you medicine to help stop that and vomiting.
  • Your doctor will tell you how much Apokyn (apomorphine) you will inject. This is given in milliliters. Turn the pen so that the correct dose is given.
  • Apokyn (apomorphine) can make you sleepy or fall asleep without warning. Don't drive or do anything that requires concentration until you know how it affects you.
  • Always change where you inject Apokyn (apomorphine) and always use a fresh needle every time. This will make injecting safer and less painful.
  • If the liquid inside the Apokyn (apomorphine) cartridge does not look clear and colorless, don't use it. Use a new cartridge or call your pharmacy.
  • Can cause you to feel faint, especially if you get up after sitting or lying down for a while. Be careful moving around after you use Apokyn (apomorphine) so you don't fall.
  • Tasmar (tolcapone) can make you dizzy if you've been sitting or lying down for a while. Be very careful when getting up.
  • Don't drive or do anything requiring concentration until you know how Tasmar (tolcapone) affects you.
  • Your urine might be colored dark orange or brown while taking Tasmar (tolcapone). This is normal.
  • You have to keep taking carbidopa/levodopa with Tasmar (tolcapone). Tasmar (tolcapone) won't work by itself to control your Parkinson's disease.
  • Talk to your doctor if you want to stop taking Tasmar (tolcapone). Stopping it suddenly can be very dangerous.
Learn more
More about ApokynSide effectsAlternativesFDA package insert
Have you used Apokyn (apomorphine)?
Worth itNot sureNot worth it
More about tolcaponeSide effectsAlternativesFDA package insert
Have you used Tasmar (tolcapone)?
Worth itNot sureNot worth it