Compare Apokyn vs. tolcapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Apokyn (apomorphine)

Prescription only

Tasmar (tolcapone)

Prescription only
Helps you move around.

Apokyn (apomorphine) is good for treating the "off" episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness.

Treats Parkinson's disease.

Taking Tasmar (tolcapone) is the next step to control Parkinson's disease when carbidopa/levodopa don't work as well, however you might be more likely to have liver damage.

Upsides
  • Preferred drug according to the guidelines to treat the "off" periods or inability to control movements well that's associated with Parkinson's.
  • People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines.
  • Tasmar (tolcapone) is part of the medicines used as the most common next step to control Parkinson's disease when carbidopa/levodopa doesn't work as well.
  • Tasmar (tolcapone) is available as a generic.
  • Tasmar (tolcapone) can be taken with or without food.
Downsides
  • Can cause vomiting and sudden sleepiness. Your doctor will have to give you a medicine to stop the vomiting from happening.
  • Apokyn (apomorphine) should only be used if you have an "off" period of moving around. You should keep using your other medicines for your Parkinson's.
  • Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams.
  • Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. Talk to your doctor if you want to stop taking this medicine.
  • When you first start taking Tasmar (tolcapone), your doctor might have to change the dose a lot because of all the side effects.
  • Tasmar (tolcapone) will only slow the disease down; it is not a cure for Parkinson's disease.
  • Unlike Comtan, Tasmar (tolcapone) is more likely to damage your liver, so you might need regular blood tests for the first few months.
  • Tasmar (tolcapone) is not available as a combination pill with carbidopa/levodopa, unlike Comtan.
  • Tasmar (tolcapone) can cause dry mouth and changes in blood pressure. Changes in blood pressure can make you feel faint and more likely to fall.
Used for
Dosage forms
  • Injection
  • Pill
Price
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$1035.15
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Lowest price near you
$1769.68
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Side effects
9possible side effects
  • Yawning
    40%
  • Movement problems
    35%
  • Drowsiness or sleepiness
    35%
  • Nausea or vomiting
    30%
  • Dizziness
    20%
  • Runny nose
    20%
  • Chest pain
    15%
  • Hallucinations
    10%
  • Swelling in arms and legs
    10%
See more detailed side effects
10possible side effects
  • Difficulty controlling movement
    42%
  • Nausea
    30%
  • Sleeping problems
    24%
  • Excessive dreaming
    21%
  • Muscle cramps
    19%
  • Loss of appetite
    19%
  • Sleepiness
    18%
  • Uncontrolled muscle spasms
    17%
  • Lightheadedness from standing
    17%
  • Diarrhea
    16%
See more detailed side effects
Risks and warnings
  • Hallucinations

    Taking antipsychotic medicines

  • Falling asleep during the day

    Taking other medicines for Parkinson's disease

  • Increased risk of heart attack or stroke

    History of heart disease or stroke

See more detailed risks and warnings
  • Liver damage

    Liver damage

  • Falling asleep during the day

    Taking other medicines for Parkinson's disease

  • Abnormal thinking and mood changes

    Taking antipsychotic medicines

  • Lack of impulse control

    Taking other medicines for Parkinson's disease

See more detailed risks and warnings