Compare Arava vs. methotrexate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Arava (Leflunomide)

Otrexup (methotrexate)

Prescription only
No information currently available
Reduces inflammation and cell replication.

Otrexup (methotrexate) is the first-choice treatment for many types of cancer and arthritis, but it has many side effects.

Upsides
No information currently available
  • Otrexup (methotrexate) is available as an affordable generic form.
  • Otrexup (methotrexate) comes as a tablet, an injection that you give yourself, or an infusion that you get in the doctor's office or infusion center.
Downsides
No information currently available
  • You may need frequent blood tests for monitoring when taking Otrexup (methotrexate).
  • Otrexup (methotrexate) can cause serious birth defects so women should avoid getting pregnant for at least 6 month and men 3 months after taking it.
  • While on Otrexup (methotrexate), you should avoid alcohol and staying out in the sun for too long.
Used for
Dosage forms
  • Pill
  • Pill
  • Injection
  • Liquid
Price
Lowest price near you
$107.45
Find instant savings
Lowest price near you
$31.32
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
The Arava (Leflunomide) FDA package insert doesn’t have numbers about how common side effects are.
The Otrexup (methotrexate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
No information currently available
  • Worsening side-effects

    Reduced kidney function

    ...and 2 more risk factors

  • Use of NSAIDs

    NSAIDS

    ...and 1 more risk factors

  • Liver problems

    Long-term use

    ...and 1 more risk factors

  • Diarrhea and mouth sores

    Taking Otrexup (methotrexate) with high-dose NSAIDs

  • Tumor lysis syndrome

    Rapidly growing tumors

  • Skin and bone tissue deterioration

    Radiotherapy

See more detailed risks and warnings