Compare Arixtra vs. Coumadin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Arixtra (fondaparinux)

Prescription only

Coumadin (warfarin)

Prescription only
Thins the blood and treats blood clots.

Arixtra (fondaparinux) is effective at treating clots, but it can increase your risk of bleeding.

Prevents blood clots.

Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.

3.8/ 5 average rating with 513 reviewsforCoumadin
Upsides
  • Arixtra (fondaparinux) is effective at treating blood clots in the extremeties and those that have travelled to the lungs.
  • A generic form is available.
  • Arixtra (fondaparinux) is a safe option for use in patients who have experienced a rare, life-threatening reaction to another anticoagulant, heparin.
  • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
  • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
  • Coumadin (warfarin) comes in numerous strengths.
  • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
Downsides
  • Arixtra (fondaparinux) should be used with caution in patients with kidney problems, as this can lead to an accumulation of the medication and increase the risk of bleeding.
  • Arixtra (fondaparinux) can cause a drop in platelet count, which can increase your risk of bleeding.
  • People who have any type of spinal or epidural procedure are more likely to have bleeding problems around the spine when taking Arixtra (fondaparinux).
  • Periodic blood tests and monitoring of your kidneys is important.
  • You have to inject yourself everyday with this medication.
  • The anti blood-clotting effects of Arixtra (fondaparinux) may remain for up to 4 days after stopping this medication in normal patients, and there is no current antidote.
  • Raises your risk of bleeding and bruising.
  • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
  • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
Used for
  • Treatment of blood clots
Dosage forms
  • Injection
  • Pill
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Reviews
Not enough review data.Leave a review
513 reviews so far
61%
saidit'sworth it
54%
saiditworked well
21%
saidit'sa big hassle

Have you used Coumadin (warfarin)?

Leave a review
Side effects
2possible side effects
  • Anemia
    2%
  • Blood clots
    2%
See more detailed side effects
The Coumadin (warfarin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Spinal/epidural blood clots
    • Indwelling epidural catheters
    • Use of other medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) or other anticoagulants
    • History of traumatic or repeated epidural or spinal puncture
    • History of spinal surgery
  • Bleeding
    • Existing condition that increases risk of bleeding
    • Surgery
    • Use of other anticoagulants
    • Kidney problems
    • Patients with low body weight (<50kg)
    • Elderly (>75 years old)
  • Kidney problems
    • Kidney problems
  • Decreased platelet count
  • Allergic reactions
    • Latex allergy
See more detailed risks and warnings
  • Life threatening bleeding
    • Coumadin (warfarin) dose too high
    • Age greater than 65 year
    • History of stomach bleeding
    • High blood pressure
    • Kidney or liver problems
    • Drug interactions
    • Change in lifestyle or diet
    • Alcohol use
    • Certain genetic factors
  • Harm to fetus
    • Women of childbearing age
  • Drug and diet interactions
  • Potential surgery or amputation
See more detailed risks and warnings