Compare Arixtra vs. Xarelto

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Coming soon.Prevents blood clots. Xarelto (rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. However, it can be expensive and there's no way to reverse the medication's effects.
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Coupons for Arixtra
Best available price for 60 (10 syringes of 7.5mg/0.6ml) cartons of fondaparinux
Coupons for Xarelto
Best available price for 30 (20mg) tablets of xarelto
Reviews & ratings
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Have you used Arixtra (fondaparinux)?
Worth itNot sureNot worth it
Reviews for Xarelto
-45% worse vs. Arixtra
-45% worse vs. Arixtra
+9% better vs. Arixtra
Have you used Xarelto (rivaroxaban)?
Worth itNot sureNot worth it
Side effects

We haven’t found good data for Arixtra side effects.

FDA side effect reports for Arixtra »
  • Major bleeding needing transfusion 4%
  • Bleeding in the stomach & intestines 2%
  • Complaints of bleeding 28%
  • Clinically relevant but not major bleeding 9%
  • Back pain 3%
  • Upper abdominal pain 2%
  • Joint arthritis 1%
  • Any bleeding event after hip or knee replacement surgery 6%
  • Any side effect causing stopping of xarelto (rivaroxaban) 4%
  • Wound drainage 3%
More Xarelto side effects »
How it works
Coming soon.Xarelto (rivaroxaban) is an anticoagulant that stops blood clots from forming.
Type of medication
Prescription only
Available as
  • Injection
  • Pill
Used for
  • Deep Venous Thrombosis
Risk factors for serious side effects
    Coming soon.
    • Stopping Xarelto (rivaroxaban) too soon
    • Artificial heart valve
    • Spinal puncture (spinal tap)
    • Getting anesthesia in the spine (epidural anesthesia)
    • History of bleeding problems
    Detailed Xarelto (rivaroxaban) risks & warnings »

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    No interactions related info.
    • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
    No food related info.
    • Like all blood thinners, it will take a little longer for your blood to clot if you start bleeding while you're taking Xarelto (rivaroxaban). Call your doctor if you notice bleeding that won't stop, a bruise that won't go away or gets worse, pink or brown urine, bright red or dark tarry stool, nose bleeds, or if you start coughing up blood.
    Kidneys and liver
    No kidneys and liver related info.
    • Xarelto (rivaroxaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to avoid other side effects.
    Upsides and benefits
    Coming soon
    • Studies show that Xarelto (rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and stopping clots from froming.
    • Xarelto (rivaroxaban) doesn't require regular blood tests or frequent dose changes.
    • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
    Downsides and risks
    Coming soon
    • Xarelto (rivaroxaban) can increase your risk of bleeding, so call your doctor right away if you see blood in your spit, urine, or stool (look for black, tarry stools or bright red blood).
    • Xarelto (rivaroxaban) isn't available as a generic medication.
    • There are no antidotes to stop bleeding caused by taking too much Xarelto (rivaroxaban).
    • You can't take Xarelto (rivaroxaban) if you are pregnant.
    Tips from our pharmacists for people taking the medication
    Coming soon
    • Xarelto (rivaroxaban) prevents blood from clotting, so it's important not to miss a dose. If you miss your daily dose, take it as soon as you remember that day. Just don't take two doses close to each other.
    • If you completely forget to take a dose, call your doctor right away.
    • When taking Xarelto (rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
    • You can crush the pills and mix it with a spoonful of applesauce, but make sure to eat some food and drink a glass of water right away.
    Learn more
    More about ArixtraSide effectsFDA package insert
    Have you used Arixtra (fondaparinux)?
    Worth itNot sureNot worth it
    More about XareltoSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Xarelto (rivaroxaban)?
    Worth itNot sureNot worth it