Compare Asacol vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lialda
(mesalamine)

Humira
(adalimumab)

Treats inflammatory bowel disease. Lialda (Mesalamine) is an effective first-line medicine for inflammatory bowel disease. There isn't a generic version and you'll have to take it multiple times a day.Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.
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Coupons for Humira
Best available price for 1 (2 pens of 40mg/0.8ml) carton of adalimumab
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Lialda (mesalamine)
Not enough review data. Review it!
of people (All ages) say Lialda (mesalamine) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Lialda (mesalamine)?
Worth itNot sureNot worth it
Reviews for Humira (adalimumab)
60%
-18% worse vs. Lialda (mesalamine)
51%
-5% worse vs. Lialda (mesalamine)
26%
-26% worse vs. Lialda (mesalamine)
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
Side effects
AsacolHumira
  • Abdominal pain 4%
  • Eructation 1%
  • Pain 6%
  • Sore throat 2%
  • Back pain 2%
More Asacol side effects »
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
How it works
AsacolHumira
Lialda (Mesalamine) is an anti-inflammatory medication. Researchers don't know exactly how Lialda (Mesalamine) works in the colon, but it seems to lower the chemicals in the body that cause inflammation.Humira (adalimumab) is a TNF blocker which stops inflammation.
Type of medication
AsacolHumira
Prescription only
Prescription only
Available as
AsacolHumira
  • Pill
  • Extended release
  • Enema
  • Suppository
  • Injection
Used for
AsacolHumira
Risk factors for serious side effects
AsacolHumira
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
Detailed Lialda (mesalamine) risks & warnings »
  • Taking other immunosuppressant medications such as Kineret or Orencia
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
Detailed Humira (adalimumab) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Kidneys and liver
AsacolHumira
  • Not a good option if you have kidney disease.
  • Lialda (Mesalamine) is broken down by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need to take a different dose of the medication.
  • Rarely, Lialda (Mesalamine) can cause liver injury, hepatitis, and liver failure. Let your doctor know and get medical attention if you notice yellowing skin or eyes.
No kidneys and liver related info.
Upsides and benefits
AsacolHumira
  • Effective first-line medication for treating and lowering the symptoms of mild inflammatory bowel disease.
  • About half the people who have mild to moderate colon inflammation and take Lialda (Mesalamine) will see improvement.
  • Available in tablets, capsules, enemas, and suppositories.
  • Certain forms of Lialda (Mesalamine) can be used during pregnancy. Talk to your doctor if you're pregnant, or plan on becoming pregnant, and you want to take Lialda (Mesalamine).
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
Downsides and risks
AsacolHumira
  • No generic versions are available for the tablets, capsules, and suppositories (meaning it could be somewhat expensive).
  • Doesn't work well for severe colon inflammation.
  • You may need to take Lialda (Mesalamine) three or four times a day.
  • Not a good option if you have kidney disease.
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
Tips from our pharmacists for people taking the medication
AsacolHumira
  • Don't take Lialda (Mesalamine) if you're allergic to aspirin. Talk to your doctor or pharmacist about any drug allergies you have before starting Lialda (Mesalamine).
  • Taking antacids with Lialda (Mesalamine) can make your inflammation worse. Talk to your doctor before you make any changes.
  • You can sunburn more easily when taking Lialda (Mesalamine). Use sunscreen and protective clothing when you go outdoors.
  • Don't break, chew, or crush the tablets because they're coated and won't work as well.
  • The suppositories should be kept in for at least 1 to 3 hours to get the most benefit.
  • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
  • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
Learn more
More about AsacolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lialda (mesalamine)?
Worth itNot sureNot worth it
More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it