Compare Asacol vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lialda
(Mesalamine)

Humira
(Adalimumab)

Treats inflammatory bowel disease. Lialda (Mesalamine) is an effective first-line medicine for inflammatory bowel disease. There isn't a generic version and you'll have to take it multiple times a day.Calms down your immune system. Humira (Adalimumab) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.
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Reviews & ratings
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Reviews for Humira (Adalimumab)
59%
41% vs. Lialda (Mesalamine)
49%
22% vs. Lialda (Mesalamine)
26%
26% vs. Lialda (Mesalamine)
Side effects
AsacolHumira
  • Pain 6%
  • Indigestion 5%
  • Constipation 4%
  • Abdominal pain 4%
  • Vomiting 3%
  • Rash 3%
  • Stiff or rigid muscles 2%
  • Sore throat 2%
  • Joint pain 2%
  • Back pain 2%
More Asacol side effects »
  • Injection site reactions 6%
  • Rash 6%
  • Positive titers 5%
  • Upper respiratory infection 4%
  • Headache 4%
  • Abdominal pain 3%
  • Urinary tract infection 3%
  • High blood pressure 2%
  • Alkaline phosphatase increased 2%
  • High blood lipid levels 2%
More Humira side effects »
How it works
AsacolHumira
Lialda (Mesalamine) is an anti-inflammatory medication. Researchers don't know exactly how Lialda (Mesalamine) works in the colon, but it seems to lower the chemicals in the body that cause inflammation.Humira (Adalimumab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
AsacolHumira
Anti-inflammatoryPrescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Available as
AsacolHumira
  • Pill
  • Extended release
  • Enema
  • Suppository
  • Injection
Used for (click to learn more)
AsacolHumira
Risk factors for serious side effects
AsacolHumira
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Phenylketonuria (PKU)
  • Kidney problems
  • Liver problems
  • Age 65 or older
  • Liver problems
  • Taking Lialda (Mesalamine) at the start of treatment
Detailed Lialda (Mesalamine) risks & warnings »
    • History of heart failure
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Taking other immunosuppressant drugs
    • History of malignancy
    • History of neurologic condition
      Detailed Humira (Adalimumab) risks & warnings »
      Pregnancy category
      AsacolHumira
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • Not a good option if you have kidney disease.
      • Lialda (Mesalamine) is broken down by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need to take a different dose of the medication.
      No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.
      • Humira (Adalimumab) can increase your risk of serious or life-threatening bacterial, fungal and viral infections. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Humira (Adalimumab). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
      Upsides and benefits
      AsacolHumira
      • Effective first-line medication for treating and lowering the symptoms of mild inflammatory bowel disease.
      • About half the people who have mild to moderate colon inflammation and take Lialda (Mesalamine) will see improvement.
      • Available in tablets, capsules, enemas, and suppositories.
      • Certain forms of Lialda (Mesalamine) can be used during pregnancy. Talk to your doctor if you're pregnant, or plan on becoming pregnant, and you want to take Lialda (Mesalamine).
      • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
      • Most people feel it's worth the hassle.
      • Once you've learned the correct way to use Humira, you can inject the medicine yourself without going to your doctor's office.
      • It's available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
      • It's an alternative for people with Crohn's disease who stopped getting better on other TNF-blockers or had side effects that made them switch.
      Downsides and risks
      AsacolHumira
      • No generic versions are available for the tablets, capsules, and suppositories (meaning it could be somewhat expensive).
      • Doesn't work well for severe colon inflammation.
      • You may need to take Lialda (Mesalamine) three or four times a day.
      • Not a good option if you have kidney disease.
      • It's an injection.
      • It's expensive because there's no generic available yet.
      • Humira lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
      • You're first dose of Humira will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
      • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
      • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
      Tips from our pharmacists for people taking the medication
      AsacolHumira
      • Don't take Lialda (Mesalamine) if you're allergic to aspirin. Talk to your doctor or pharmacist about any drug allergies you have before starting Lialda (Mesalamine).
      • Taking antacids with Lialda (Mesalamine) can make your inflammation worse. Talk to your doctor before you make any changes.
      • You can sunburn more easily when taking Lialda (Mesalamine). Use sunscreen and protective clothing when you go outdoors.
      • Don't break, chew, or crush the tablets because they're coated and won't work as well.
      • The suppositories should be kept in for at least 1 to 3 hours to get the most benefit.
      • Humira (Adalimumab) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
      • Humira (Adalimumab) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
      • You'll need to have a TB test before you start using Humira (Adalimumab).
      • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
      • Don't inject Humira (Adalimumab) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
      • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
      Learn more
      More about AsacolSide effectsReviews & ratingsAlternativesFDA package insert
      More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert