Compare Asacol vs. Remicade

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lialda
(mesalamine)

Remicade
(infliximab)

Treats inflammatory bowel disease. Lialda (Mesalamine) is an effective first-line medicine for inflammatory bowel disease. There isn't a generic version and you'll have to take it multiple times a day.Calms down your immune system. Remicade (infliximab) is an effective treatment for many autoimmune diseases, but you can have serious side effects.
Reviews & ratings
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Have you used Lialda (mesalamine)?
Worth itNot sureNot worth it
Reviews for Remicade
76%
+2% better vs. Asacol
62%
-6% worse vs. Asacol
15%
+15% better vs. Asacol
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it
Side effects
AsacolRemicade
  • Abdominal pain 4%
  • Eructation 1%
  • Pain 6%
  • Sore throat 2%
  • Back pain 2%
More Asacol side effects »
  • Upper airway infection 7%
  • Nausea 1%
  • Headache 4%
  • Sinus infection 6%
  • Sore throat 4%
  • Coughinng 4%
  • Abdominal pain 4%
  • Bronchitis 1%
  • Rash 5%
More Remicade side effects »
How it works
AsacolRemicade
Lialda (Mesalamine) is an anti-inflammatory medication. Researchers don't know exactly how Lialda (Mesalamine) works in the colon, but it seems to lower the chemicals in the body that cause inflammation.Remicade (infliximab) blocks a protein in your immune system called TNF (tumor necrosis factor) that causes inflammation.
Type of medication
AsacolRemicade
Prescription onlyPrescription only
Available as
AsacolRemicade
  • Pill
  • Extended release
  • Enema
  • Suppository
  • Injection
Used for
AsacolRemicade
Risk factors for serious side effects
AsacolRemicade
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
Detailed Lialda (mesalamine) risks & warnings »
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Comorbidities
  • History of malignancy
Detailed Remicade (infliximab) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
AsacolRemicade
  • Lialda (Mesalamine) is broken down by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need to take a different dose of the medication.
  • Rarely, Lialda (Mesalamine) can cause liver injury, hepatitis, and liver failure. Let your doctor know and get medical attention if you notice yellowing skin or eyes.
  • Not a good option if you have kidney disease.
No kidneys and liver related info.
Weight
AsacolRemicade
No weight related info.
  • Although rare, Remicade (infliximab) can hurt your liver. If you have appetite/weight loss, stomach discomfort, vomiting, or dark urine, talk to your doctor. If you have yellowing of skin/eyes, talk to your doctor right away.
Upsides and benefits
AsacolRemicade
  • Effective first-line medication for treating and lowering the symptoms of mild inflammatory bowel disease.
  • About half the people who have mild to moderate colon inflammation and take Lialda (Mesalamine) will see improvement.
  • Available in tablets, capsules, enemas, and suppositories.
  • Certain forms of Lialda (Mesalamine) can be used during pregnancy. Talk to your doctor if you're pregnant, or plan on becoming pregnant, and you want to take Lialda (Mesalamine).
  • People taking Remicade (infliximab) for ulcerative colitis, Crohn's disease, rheumatoid arthritis and other autoimmune conditions had more clinical response, clinical remission and symptom improvement compared to people who did not take Remicade (infliximab).
  • People who were also taking steroids for treatment were able to discontinue steroid use while taking Remicade (infliximab).
  • Remicade (infliximab) has almost two decades of clinical trial data and real-life experience with many people who have used it.
  • After the initial dosing, you only need to take Remicade (infliximab) every 6-8 weeks, depending on your condition.
  • Compared to other medications used to treat autoimmune conditions, Remicade (infliximab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
Downsides and risks
AsacolRemicade
  • No generic versions are available for the tablets, capsules, and suppositories (meaning it could be somewhat expensive).
  • Doesn't work well for severe colon inflammation.
  • You may need to take Lialda (Mesalamine) three or four times a day.
  • Not a good option if you have kidney disease.
  • You have to receive this medication at your doctor's office or clinic. You might need to be tested regularly for tuberculosis.
  • Remicade (infliximab) lowers your ability to fight infection and can cause serious illness. The risk is greater if you take other drugs that lower your immune system, or have a history of diabetes or tuberculosis.
  • Remicade (infliximab) can in some cases worsen symptoms of heart failure or neurologic conditions. People 65 years and older may have more side effects from this medication.
  • In rare cases, Remicade (infliximab) has been associated with cancers in children and adolescents.
  • No generic available, so it can be costly.
Tips from our pharmacists for people taking the medication
AsacolRemicade
  • Don't take Lialda (Mesalamine) if you're allergic to aspirin. Talk to your doctor or pharmacist about any drug allergies you have before starting Lialda (Mesalamine).
  • Taking antacids with Lialda (Mesalamine) can make your inflammation worse. Talk to your doctor before you make any changes.
  • You can sunburn more easily when taking Lialda (Mesalamine). Use sunscreen and protective clothing when you go outdoors.
  • Don't break, chew, or crush the tablets because they're coated and won't work as well.
  • The suppositories should be kept in for at least 1 to 3 hours to get the most benefit.
  • Remicade (infliximab) can in some cases cause a serious allergic reaction either immediately or several days after the treatment. Your doctor can give you medicines that will lower this risk.
  • Your doctor will test you for tuberculosis before taking Remicade (infliximab) and regularly during treatment.
  • Remicade (infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms.
  • You should not receive any live vaccines while taking Remicade (infliximab). Tell your doctor that you are taking Remicade (infliximab) before receiving any vaccines.
  • If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
Learn more
More about AsacolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lialda (mesalamine)?
Worth itNot sureNot worth it
More about RemicadeSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it