Compare Aspirin vs. Diclofenac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aspirin

Over-the-counter

Zorvolex (Diclofenac)

Prescription only
Relieves pain, fever, and inflammation. Protects your heart and thins blood.

A low dose of Aspirin (81mg) every day can protect your heart, but it's not the best medicine to take for pain, swelling, or fever.

5.2/ 7 average rating with 533 reviewsforAspirin
Treats arthritis pain and swelling.

Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.

Upsides
  • When taking low doses (81 mg) every day, Aspirin provides protection for your heart and prevents heart attacks and stroke.
  • Used in higher doses to relieve pain, swelling, and fever.
  • Available over-the-counter in drugstores by itself and in combination with other cold and flu medications.
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
Downsides
  • Not a preferred medication for treating pain, swelling, or fever due to its high risk of bleeding.
  • NSAIDs (like ibuprofen and naproxen) and acetaminophen (Tylenol) are better for treating pain and fever thank Aspirin.
  • Aspirin raises your risk of bleeding, especially when used with other blood thinner medications like warfarin (Coumadin).
  • Studies show that using higher doses of Aspirin (162 mg or more) every day raises your risk of stomach bleeding and doesn't provide any additional heart protection.
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
Used for
Dosage forms
  • Pill
  • Pill
Price
No pricing information available
Lowest price near you
$334.28
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Reviews
533 
76%
think this treatment is worth it
41%
think this treatment works well
6%
think this treatment is a hassle

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Side effects
The Aspirin FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Upper respiratory tract infection
    8%
  • Headache
    8%
  • Nausea
    7%
  • Urinary tract infection
    7%
  • Diarrhea
    6%
  • Nasopharyngitis
    6%
  • Constipation
    5%
  • Sinusitis
    5%
  • Osteoarthritis
    5%
See more detailed side effects
Risks and warnings
  • Brain damage or death from Reye's Syndrome

    Children 18 years or younger

    ...and 1 more risk factors

  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Serious allergic reactions

    Asthma

    ...and 4 more risk factors

  • Harm to unborn babies

    Women of childbearing age

See more detailed risks and warnings
  • Heart attack or stroke

    History of heart problems

    ...and 5 more risk factors

  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 1 more risk factors

  • Bruising or bleeding

    Bleeding disorder

    ...and 1 more risk factors

  • Serious allergic reactions

    Asthma

    ...and 4 more risk factors

  • Lowers kidney function

    Kidney problems

    ...and 5 more risk factors

  • Increased blood pressure

    History of high blood pressure

    ...and 1 more risk factors

See more detailed risks and warnings