Compare Aspirin vs. Eliquis

Head-to-head comparisons of medication uses, side effects, ratings, and more.

aspirin

Eliquis
(apixaban)

Relieves pain, fever, and inflammation. Protects your heart and thins blood. A low dose of Aspirin (81mg) every day can protect your heart, but it's not the best medicine to take for pain, swelling, or fever.Prevents blood clots. Eliquis (apixaban) is an effective way to prevent blood clots from forming in your veins, but you have to take it twice a day, and your doctor might have to change the dose a lot.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.15Aspirin
Reviews for Aspirin
76%
of people (All ages) say Aspirin is worth it
41%
say it works well
6%
say it's a big hassle
533 reviews
Have you used Aspirin?
Worth itNot sureNot worth it
Reviews for Eliquis
47%
+29% better vs. Aspirin
58%
-17% worse vs. Aspirin
21%
+15% better vs. Aspirin
Have you used Eliquis (apixaban)?
Worth itNot sureNot worth it
Side effects
AspirinEliquis

We haven’t found good data for Aspirin side effects.

FDA side effect reports for Aspirin »
  • Major bleed 2%
  • Bleeding 12%
  • Nausea 3%
  • Anemia 3%
  • Severe bruising 2%
  • Blood in the urine 2%
  • Nose bleeding 3%
  • All bleeding 15%
  • Blood clots 1%
  • Nosebleeds 3%
More Eliquis side effects »
How it works
AspirinEliquis
Aspirin is a salicylate and non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain. It also prevents blood platelets from forming clots, which thins your blood.Eliquis (apixaban) is a factor Xa inhibitor anticoagulant that stops the formation of blood clots in your body so you're less likely to have a stroke or heart attack.
Type of medication
AspirinEliquis
Over-the-counterLower-cost generic availablePrescription onlyNo lower cost generic available
Available as
AspirinEliquis
  • Pill
  • Pill
Used for
AspirinEliquis
Risk factors for serious side effects
AspirinEliquis
  • Children 18 years or younger
  • Children recovering from viral infections
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking Aspirin, NSAIDs, or blood thinners
Detailed Aspirin risks & warnings »
  • Stopping Eliquis (apixaban) prematurely
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of spinal surgery
  • Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs), or other blood-thinners
Detailed Eliquis (apixaban) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
AspirinEliquis
No interactions related info.
  • Eliquis (apixaban) can interact with different medicines. Make sure your doctor and pharmacist know all the medicines you're taking.
Food
AspirinEliquis
  • Take with food to lower the chance of an upset stomach.
  • Take twice a day, with or without food, at the same time each day.
Kidneys and liver
AspirinEliquis
No kidneys and liver related info.
  • Eliquis (apixaban) is broken down by the kidney and liver. If you already have problems with your kidney or liver, talk to your doctor to make sure Eliquis (apixaban) is right for you.
Pain
AspirinEliquis
  • Used in higher doses to relieve pain, swelling, and fever.
No pain related info.
Upsides and benefits
AspirinEliquis
  • When taking low doses (81 mg) every day, Aspirin provides protection for your heart and prevents heart attacks and stroke.
  • Used in higher doses to relieve pain, swelling, and fever.
  • Available over-the-counter in drugstores by itself and in combination with other cold and flu medications.
  • Eliquis (apixaban) is very effective in reducing the risk of stroke in people with atrial fibrilation or other clotting disorders.
  • You don't need to have regular blood tests on Eliquis (apixaban), and you don't have to regulate your diet like other blood thinners.
  • If you've had clots in your legs or lungs before, Eliquis (apixaban) can lower the risk of these forming again.
Downsides and risks
AspirinEliquis
  • Not a preferred medication for treating pain, swelling, or fever due to its high risk of bleeding.
  • NSAIDs (like ibuprofen and naproxen) and acetaminophen (Tylenol) are better for treating pain and fever thank Aspirin.
  • Aspirin raises your risk of bleeding, especially when used with other blood thinner medications like warfarin (Coumadin).
  • Studies show that using higher doses of Aspirin (162 mg or more) every day raises your risk of stomach bleeding and doesn't provide any additional heart protection.
  • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or bloody stools.
  • Can't be used if you have artificial heart valves.
  • Never stop taking Eliquis (apixaban) without talking to your doctor first.
  • Eliquis (apixaban) isn't available as a generic, so it can be expensive.
  • If you've taken too much Eliquis (apixaban) and you're bleeding, it can be harder to treat compared to other blood thinners.
Tips from our pharmacists for people taking the medication
AspirinEliquis
  • Using low doses (81mg) of Aspirin every day can lower your risk of heart attack and stroke, but it isn't good for everyone. Only take Aspirin daily if your doctor recommends it.
  • Higher Aspirin doses can be used to treat occasional pain, swelling, and fever. Using ibuprofen or acetaminophen (Tylenol) instead can lower your risk of serious bleeding.
  • Take with food to lower the chance of an upset stomach.
  • Don't use for kids younger than 18 years old.
  • Stop taking this right away and tell your doctor if you have ringing in your ears, unusual bleeding, or nausea or vomiting that doesn't go away.
  • Take twice a day, with or without food, at the same time each day.
  • If you're going to have a dental procedure or surgery, make sure your dentist or surgeon talks to your doctor first.
  • You can bruise easier while taking Eliquis (apixaban) and if you have a cut, it can take longer for bleeding to stop.
  • Eliquis (apixaban) can interact with different medicines. Make sure your doctor and pharmacist know all the medicines you're taking.
  • Call a doctor immediately if you have dizziness, weakness, or a really bad headache.
Learn more
More about AspirinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aspirin?
Worth itNot sureNot worth it
More about EliquisSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Eliquis (apixaban)?
Worth itNot sureNot worth it