Compare Aspirin vs. Xarelto

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Relieves pain, fever, and inflammation. Protects your heart and thins blood. A low dose of Aspirin (81mg) every day can protect your heart, but it's not the best medicine to take for pain, swelling, or fever.Prevents blood clots. Xarelto (rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. However, it can be expensive and there's no way to reverse the medication's effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Aspirin
of people (All ages) say Aspirin is worth it
say it works well
say it's a big hassle
533 reviews
Have you used Aspirin?
Worth itNot sureNot worth it
Reviews for Xarelto
+31% better vs. Aspirin
-4% worse vs. Aspirin
+3% better vs. Aspirin
Have you used Xarelto (rivaroxaban)?
Worth itNot sureNot worth it
Side effects

We haven’t found good data for Aspirin side effects.

FDA side effect reports for Aspirin »
  • Major bleeding needing transfusion 4%
  • Bleeding in the stomach & intestines 2%
  • Complaints of bleeding 28%
  • Clinically relevant but not major bleeding 9%
  • Back pain 3%
  • Upper abdominal pain 2%
  • Joint arthritis 1%
  • Any bleeding event after hip or knee replacement surgery 6%
  • Any side effect causing stopping of Xarelto (rivaroxaban) 4%
  • Wound drainage 3%
More Xarelto side effects »
How it works
Aspirin is a salicylate and non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain. It also prevents blood platelets from forming clots, which thins your blood.Xarelto (rivaroxaban) is an anticoagulant that stops blood clots from forming.
Type of medication
Over-the-counterPrescription only
Available as
  • Pill
  • Pill
Used for
Risk factors for serious side effects
  • Children 18 years or younger
  • Children recovering from viral infections
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking Aspirin, NSAIDs, or blood thinners
Detailed Aspirin risks & warnings »
  • Stopping Xarelto (rivaroxaban) too soon
  • Artificial heart valve
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of bleeding problems
Detailed Xarelto (rivaroxaban) risks & warnings »

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

No interactions related info.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
  • Take with food to lower the chance of an upset stomach.
  • Like all blood thinners, it will take a little longer for your blood to clot if you start bleeding while you're taking Xarelto (rivaroxaban). Call your doctor if you notice bleeding that won't stop, a bruise that won't go away or gets worse, pink or brown urine, bright red or dark tarry stool, nose bleeds, or if you start coughing up blood.
Kidneys and liver
No kidneys and liver related info.
  • Xarelto (rivaroxaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to avoid other side effects.
  • Used in higher doses to relieve pain, swelling, and fever.
No pain related info.
Upsides and benefits
  • When taking low doses (81 mg) every day, Aspirin provides protection for your heart and prevents heart attacks and stroke.
  • Used in higher doses to relieve pain, swelling, and fever.
  • Available over-the-counter in drugstores by itself and in combination with other cold and flu medications.
  • Studies show that Xarelto (rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and stopping clots from froming.
  • Xarelto (rivaroxaban) doesn't require regular blood tests or frequent dose changes.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
Downsides and risks
  • Not a preferred medication for treating pain, swelling, or fever due to its high risk of bleeding.
  • NSAIDs (like ibuprofen and naproxen) and acetaminophen (Tylenol) are better for treating pain and fever thank Aspirin.
  • Aspirin raises your risk of bleeding, especially when used with other blood thinner medications like warfarin (Coumadin).
  • Studies show that using higher doses of Aspirin (162 mg or more) every day raises your risk of stomach bleeding and doesn't provide any additional heart protection.
  • Xarelto (rivaroxaban) can increase your risk of bleeding, so call your doctor right away if you see blood in your spit, urine, or stool (look for black, tarry stools or bright red blood).
  • Xarelto (rivaroxaban) isn't available as a generic medication.
  • There are no antidotes to stop bleeding caused by taking too much Xarelto (rivaroxaban).
  • You can't take Xarelto (rivaroxaban) if you are pregnant.
Tips from our pharmacists for people taking the medication
  • Using low doses (81mg) of Aspirin every day can lower your risk of heart attack and stroke, but it isn't good for everyone. Only take Aspirin daily if your doctor recommends it.
  • Higher Aspirin doses can be used to treat occasional pain, swelling, and fever. Using ibuprofen or acetaminophen (Tylenol) instead can lower your risk of serious bleeding.
  • Take with food to lower the chance of an upset stomach.
  • Don't use for kids younger than 18 years old.
  • Stop taking this right away and tell your doctor if you have ringing in your ears, unusual bleeding, or nausea or vomiting that doesn't go away.
  • Xarelto (rivaroxaban) prevents blood from clotting, so it's important not to miss a dose. If you miss your daily dose, take it as soon as you remember that day. Just don't take two doses close to each other.
  • If you completely forget to take a dose, call your doctor right away.
  • When taking Xarelto (rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
  • You can crush the pills and mix it with a spoonful of applesauce, but make sure to eat some food and drink a glass of water right away.
Learn more
More about AspirinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aspirin?
Worth itNot sureNot worth it
More about XareltoSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Xarelto (rivaroxaban)?
Worth itNot sureNot worth it