Compare Aspirin vs. Xarelto

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Relieves pain, fever, and inflammation. Protects your heart and thins blood. A low dose of Aspirin (81mg) every day can protect your heart, but it's not the best medicine to take for pain, swelling, or fever.Prevents blood clots. Xarelto (Rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.
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  • Cost for (30) 81mg tablets of Aspirin
Reviews & ratings
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Reviews for Aspirin
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Side effects

We haven’t found good data for Aspirin side effects.

FDA side effect reports for Aspirin »
  • Back pain 3%
More Xarelto side effects »
How it works
Aspirin is a salicylate and non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain. It also prevents blood platelets from forming clots, which thins your blood.Xarelto (Rivaroxaban) is an anticoagulant that stops the formation of blood clots.
Type of medication
Pain reliever
Factor Xa inhibitor
Prescription only
Available as
  • Pill
  • Pill
Used for (click to learn more)
Risk factors for serious side effects
  • Children 18 years or younger
  • Children recovering from viral infections
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking Aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Women of childbearing age
Detailed Aspirin risks & warnings »
  • Stopping Xarelto (Rivaroxaban) too soon
  • Artificial heart valve
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of bleeding problems
  • Severe high blood pressure
  • Age 65 or older
  • Drug interactions
  • Taking NSAIDs, aspirin, or other blood-thinning medicines
  • Current kidney problems
  • Current liver problems
Detailed Xarelto (Rivaroxaban) risks & warnings »
Pregnancy category
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
No specific alcohol-related info.No specific alcohol-related info.
  • Take with food to lower the chance of an upset stomach.
  • Xarelto (Rivaroxaban) doesn't have as many food interactions as compared to other anticoagulants like warfarin (Coumadin).
  • Take Xarelto (Rivaroxaban) with food and a full glass of water.
Kidneys and liver
No specific kidneys and liver-related info.
  • Xarelto (Rivaroxaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to prevent increased risk for side effects.
No specific sex-related info.No specific sex-related info.
No specific sleep-related info.No specific sleep-related info.
No specific weight-related info.No specific weight-related info.
Upsides and benefits
  • When taking low doses (81 mg) every day, Aspirin provides protection for your heart and prevents heart attacks and stroke.
  • Used in higher doses to relieve pain, swelling, and fever.
  • Available over-the-counter in drugstores by itself and in combination with other cold and flu medications.
  • Studies have shown that Xarelto (Rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and reducing bleeding.
  • Xarelto (Rivaroxaban) doesn't require regular blood testing or frequent dose adjustments.
  • Xarelto (Rivaroxaban) doesn't have as many food interactions as compared to other anticoagulants like warfarin (Coumadin).
Downsides and risks
  • Not a preferred medication for treating pain, swelling, or fever due to its high risk of bleeding.
  • NSAIDs (like ibuprofen and naproxen) and acetaminophen (Tylenol) are better for treating pain and fever thank Aspirin.
  • Aspirin raises your risk of bleeding, especially when used with other blood thinner medications like warfarin (Coumadin).
  • Studies show that using higher doses of Aspirin (162 mg or more) every day raises your risk of stomach bleeding and doesn't provide any additional heart protection.
  • Xarelto (Rivaroxaban) can increase your risk of bleeding. Call your doctor right away if there is blood in your phlegm, urine, or stool (look for black, tarry stools).
  • Xarelto (Rivaroxaban) isn't available as a generic medication.
  • There are no antidotes to stop bleeding caused by taking too much Xarelto (Rivaroxaban).
  • Can't take during pregnancy.
Tips from our pharmacists for people taking the medication
  • Using low doses (81mg) of Aspirin every day can lower your risk of heart attack and stroke, but it isn't good for everyone. Only take Aspirin daily if your doctor recommends it.
  • Higher Aspirin doses can be used to treat occasional pain, swelling, and fever. Using ibuprofen or acetaminophen (Tylenol) instead can lower your risk of serious bleeding.
  • Take with food to lower the chance of an upset stomach.
  • Don't use for kids younger than 18 years old.
  • Stop taking this right away and tell your doctor if you have ringing in your ears, unusual bleeding, or nausea or vomiting that doesn't go away.
  • Xarelto (Rivaroxaban) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
  • When taking Xarelto (Rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
  • Take Xarelto (Rivaroxaban) with food and a full glass of water.
  • You can crush the tablets and mix with applesauce.
Learn more
More about AspirinSide effectsReviews & ratingsAlternativesFDA package insert
More about XareltoSide effectsReviews & ratingsAlternativesFDA package insert