Compare Astepro vs. Afrin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Astepro (Azelastine)

Prescription only

Afrin (oxymetazoline)

Prescription or OTC
Relieves nasal allergy symptoms.

Astepro (Azelastine) is a prescription-only antihistamine nasal spray that can help with your allergy or nasal symptoms without exposing the rest of your body to the medicine.

Clears your sinuses.

Afrin (oxymetazoline) clears stuffy noses, but can worsen your congestion if it is used more frequently than 3 days in a row.

5.1/ 7 average rating with 599 reviewsforAfrin
Upsides
  • Astepro (Azelastine) lowers the number of nasal symptoms you'll get during allergy season.
  • Works faster than steroid nasal sprays and can be used as needed.
  • Most people don't have any side effects since it works in the nose and doesn't affect the rest of your body.
  • Won't make you feel sleepy.
  • Works just as well as steroid nasal sprays.
  • It works right away and each dose lasts up to 12 hours.
  • The effect is limited to your nasal passageways so it may be safer than other decongestants you take orally.
  • Available as a nasal spray and a nasal mist.
  • Can be purchased over-the-counter without a prescription.
Downsides
  • In older versions of the medicine, you can get a bitter taste in your mouth after spraying it into your nose.
  • Can cause nose bleeds if the spray nozzle is inserted into your nose wrongly.
  • Need a prescription to get Astepro (Azelastine).
  • It's good for 200 sprays, but there isn't a counter to help you keep track of sprays.
  • Sometimes Afrin (oxymetazoline) causes temporary stinging, burning, or dryness of the nose.
  • Talk to your doctor first before using it in children younger than 6 years old.
Used for
Dosage forms
  • Nasal spray
  • Nasal spray
Price
Lowest price near you
$26.45
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Reviews
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599 
71%
think this treatment is worth it
47%
think this treatment works well
12%
think this treatment is a hassle

Have you used Afrin (oxymetazoline)?

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Side effects
4possible side effects
  • Rhinitis
    17%
  • Cough
    11%
  • Conjunctivitis
    5%
  • Asthma
    5%
See more detailed side effects
The Afrin (oxymetazoline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

See more detailed risks and warnings
  • Rebound nasal congestion

    Using Afrin (oxymetazoline) for more than 3 days

See more detailed risks and warnings