Compare Astepro vs. Claritin

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Relieves nasal allergy symptoms. Astepro (Azelastine) is a prescription-only antihistamine nasal spray that can help with your allergy or nasal symptoms without exposing the rest of your body to the medicine.Treats allergy symptoms. Claritin (Loratadine) is a once-daily allergy relief medication that doesn't make you feel sleepy.
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Have you used Astepro (Azelastine)?
Worth itNot sureNot worth it
Reviews for Claritin (Loratadine)
-15% worse vs. Astepro (Azelastine)
-62% worse vs. Astepro (Azelastine)
+16% better vs. Astepro (Azelastine)
1517 reviews
Have you used Claritin (Loratadine)?
Worth itNot sureNot worth it
Side effects
  • Bitter taste 19%
  • Headache 2%
  • Drowsiness 7%
  • Sore throat 1%
  • Nasal burning 2%
  • Nasal discomfort 4%
  • Paroxysmal sneezing 2%
  • Dry mouth 1%
  • Nausea 2%
More Astepro side effects »

We haven’t found good data for Claritin side effects.

FDA side effect reports for Claritin »
How it works
Astepro (Azelastine) is an antihistamine nasal spray. It works directly in your nose to block histamine, a chemical that causes runny nose, itching, and sneezing.Claritin (Loratadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. Antihistamines can also make you sleepy, but Loratadine is a low-drowsiness version.
Type of medication
Prescription only
Prescription or OTC
Available as
  • Nasal spray
  • Pill
  • Chewable tablet
  • Orally disintegrating tablet
  • Liquid
Used for
Risk factors for serious side effects
  • Taking with alcohol
  • Taking other medicines that make you less alert
Detailed Astepro (Azelastine) risks & warnings »
    • Age 65 or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • History of phenylketonuria (PKU)
    Detailed Claritin (Loratadine) risks & warnings »

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    No food related info.
    • Claritin (Loratadine) contains aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, don't use this product.
    • Won't make you feel sleepy.
    • Can make you feel sleepy, so take it at bedtime if needed.
    Upsides and benefits
    • Astepro (Azelastine) lowers the number of nasal symptoms you'll get during allergy season.
    • Works faster than steroid nasal sprays and can be used as needed.
    • Most people don't have any side effects since it works in the nose and doesn't affect the rest of your body.
    • Won't make you feel sleepy.
    • Works just as well as steroid nasal sprays.
    • Relieves allergy symptoms like sneezing and runny nose just as well as other antihistamines, but with less sedation (drowsiness).
    • Also treats hives and itchy skin.
    • Side effects are rare and usually mild.
    • Available over the counter without a prescription.
    • Comes as a tablet, liquid, or quick-dissolving tablet.
    • Can provide quick relief of allergy symptoms for both kids and adults.
    • Okay to take with most other medications because it doesn't have many interactions.
    Downsides and risks
    • In older versions of the medicine, you can get a bitter taste in your mouth after spraying it into your nose.
    • Can cause nose bleeds if the spray nozzle is inserted into your nose wrongly.
    • Need a prescription to get Astepro (Azelastine).
    • It's good for 200 sprays, but there isn't a counter to help you keep track of sprays.
    • For some people, its effectiveness on treating allergies wears off over time.
    • Some people find that other more sedating antihistamines (like Zyrtec or Benadryl) are more effective for them.
    • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
    • Not for kids under 2 years.
    • The Reditabs version contains aspartame (phenylalanine).
    Tips from our pharmacists for people taking the medication
    • Starts working in 15 minutes.
    • Check with your doctor or pharmacist to make sure you know how to use this nose spray correctly.
    • Before using the spray for the first time, prime it until you see a fine mist.
    • Clear your nose before using the spray and breathe in slowly as you're spraying. After spraying, wait a few minutes before blowing your nose if needed.
    • Tilt your head forward to avoid getting a bitter taste while spraying the medicine.
    • Some people get a headache or feel drowsy and dizzy after using it.
    • Take it only once a day.
    • Starts working in a few hours.
    • Can make you feel sleepy, so take it at bedtime if needed.
    • Avoid possible side effects by drinking plenty of non-caffeinated liquids.
    • If you need to use it for more than a few weeks, talk with your doctor about trying a nasal steroid instead, which might work better for you long-term.
    • Using an antihistamine eye drop might work better to help itchy or watery eyes.
    Learn more
    More about AsteproSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Astepro (Azelastine)?
    Worth itNot sureNot worth it
    More about ClaritinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Claritin (Loratadine)?
    Worth itNot sureNot worth it