Compare Astepro vs. Flonase

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Astepro
(Azelastine)

Flonase
(Fluticasone)

Relieves nasal allergy symptoms. Astepro (Azelastine) is a prescription-only antihistamine nasal spray that can help with your allergy or nasal symptoms without exposing the rest of your body to the medicine.Relieves allergy symptoms. Flonase (Fluticasone) is a good first-choice medicine for treating a runny or stuffy nose caused by allergies, and it's cheaper than some alternatives.
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Reviews & ratings
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Reviews for Flonase (Fluticasone)
72%
28% vs. Astepro (Azelastine)
43%
57% vs. Astepro (Azelastine)
7%
7% vs. Astepro (Azelastine)
Side effects
AsteproFlonase
  • Bitter taste 19%
  • Inflammation inside the nose 7%
  • Drowsiness 7%
  • Nosebleed 4%
  • Pink eye 3%
  • Cough 3%
  • Nasal burning 2%
  • Sneezing 2%
  • Nausea 2%
  • Paroxysmal sneezing 2%
More Astepro side effects »
  • Asthma symptoms 4%
  • Nausea/vomiting 3%
  • Nosebleed 2%
  • Headache 1%
  • Cough 1%
  • Sore throat 1%
More Flonase side effects »
How it works
AsteproFlonase
Astepro (Azelastine) is an antihistamine nasal spray. It works directly in your nose to block histamine, a chemical that causes runny nose, itching, and sneezing.Flonase (Fluticasone) is a nasal steroid. It works directly in your nose to reduce swelling and inflammation caused by allergies.
Type of medication
AsteproFlonase
Antihistamine
2nd generation
Prescription only
Anti-inflammatory
Corticosteroid
Prescription or OTC
Available as
AsteproFlonase
  • Nasal spray
  • Nasal spray
Used for (click to learn more)
AsteproFlonase
Risk factors for serious side effects
AsteproFlonase
  • Taking with alcohol
  • Taking other medicines that make you less alert
Detailed Astepro (Azelastine) risks & warnings »
  • Switching from oral or injectable steroids to inhaled, especially if used long term
  • Using other inhaled steroids with Flonase (Fluticasone)
    • Long-term use
    • Taking more than recommended dose
    • Switching from oral or injectable steroids to inhaled, especially if used long term
    • Using other inhaled steroids with Flonase (Fluticasone)
    • Long-term use
    • Exposure to immunizable diseases (chickenpox and measles)
    • Exposure to tuberculosis
    • Surgery or trauma to the nose or sinuses
    • Long-term use
    Detailed Flonase (Fluticasone) risks & warnings »
    Pregnancy category
    AsteproFlonase
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    • Some people get a headache or feel drowsy and dizzy after using it.
    No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    AsteproFlonase
    • Astepro (Azelastine) lowers the number of nasal symptoms you'll get during allergy season.
    • Works faster than steroid nasal sprays and can be used as needed.
    • Most people don't have any side effects since it works in the nose and doesn't affect the rest of your body.
    • Won't make you feel sleepy.
    • Works just as well as steroid nasal sprays.
    • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
    • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
    • Can be used as needed to help control symptoms in people age 13 years or older.
    • Available as a generic medication.
    Downsides and risks
    AsteproFlonase
    • In older versions of the medicine, you can get a bitter taste in your mouth after spraying it into your nose.
    • Can cause nose bleeds if the spray nozzle is inserted into your nose wrongly.
    • Need a prescription to get Astepro (Azelastine).
    • It's good for 200 sprays, but there isn't a counter to help you keep track of sprays.
    • Flonase (Fluticasone) doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
    • Needs to be primed (pressed/pumped until a fine spray appears) up to six times prior to using it for the first time, or if you haven't used it in 2 weeks.
    • Since the medicine in Flonase (Fluticasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
    Tips from our pharmacists for people taking the medication
    AsteproFlonase
    • Starts working in 15 minutes.
    • Check with your doctor or pharmacist to make sure you know how to use this nose spray correctly.
    • Before using the spray for the first time, prime it until you see a fine mist.
    • Clear your nose before using the spray and breathe in slowly as you're spraying. After spraying, wait a few minutes before blowing your nose if needed.
    • Tilt your head forward to avoid getting a bitter taste while spraying the medicine.
    • Some people get a headache or feel drowsy and dizzy after using it.
    • It can take several days for Flonase (Fluticasone) to start working fully.
    • Don't take more of it than was prescribed for you.
    • Blow your nose before using Flonase (Fluticasone).
    • Can cause thrush (a fungal infection) inside the nose and throat.
    • Can also cause a headache, sore throat, or nosebleeds.
    Learn more
    More about AsteproSide effectsReviews & ratingsAlternativesFDA package insert
    More about FlonaseSide effectsReviews & ratingsAlternativesFDA package insert