Compare Astepro vs. Sudafed

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Astepro
(Azelastine)

Sudafed
(Pseudoephedrine)

Relieves nasal allergy symptoms. Astepro (Azelastine) is a prescription-only antihistamine nasal spray that can help with your allergy or nasal symptoms without exposing the rest of your body to the medicine.Clears your sinuses. Sudafed (Pseudoephedrine) relieves stuffy nose, but it could keep you up at night. Don't forget your photo ID or you won't be able to buy it in the drugstore.
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Reviews & ratings
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Reviews for Sudafed (Pseudoephedrine)
82%
18% vs. Astepro (Azelastine)
45%
55% vs. Astepro (Azelastine)
6%
6% vs. Astepro (Azelastine)
Side effects
AsteproSudafed
  • Bitter taste 19%
  • Inflammation inside the nose 7%
  • Drowsiness 7%
  • Nosebleed 4%
  • Pink eye 3%
  • Cough 3%
  • Nasal burning 2%
  • Sneezing 2%
  • Nausea 2%
  • Paroxysmal sneezing 2%
More Astepro side effects »

We haven’t found good data for Sudafed side effects.

FDA side effect reports for Sudafed »
How it works
AsteproSudafed
Astepro (Azelastine) is an antihistamine nasal spray. It works directly in your nose to block histamine, a chemical that causes runny nose, itching, and sneezing.Sudafed (Pseudoephedrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.
Type of medication
AsteproSudafed
Antihistamine
2nd generation
Prescription only
DecongestantPrescription or OTC
Available as
AsteproSudafed
  • Nasal spray
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
AsteproSudafed
Risk factors for serious side effects
AsteproSudafed
  • Taking with alcohol
  • Taking other medicines that make you less alert
Detailed Astepro (Azelastine) risks & warnings »
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
  • History of seizures
  • Women of childbearing age
Detailed Sudafed (Pseudoephedrine) risks & warnings »
Pregnancy category
AsteproSudafed
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • Some people get a headache or feel drowsy and dizzy after using it.
  • It can affect the quality of your sleep, so you can't take it too close to going to bed.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
AsteproSudafed
  • Astepro (Azelastine) lowers the number of nasal symptoms you'll get during allergy season.
  • Works faster than steroid nasal sprays and can be used as needed.
  • Most people don't have any side effects since it works in the nose and doesn't affect the rest of your body.
  • Won't make you feel sleepy.
  • Works just as well as steroid nasal sprays.
  • One of the best over-the-counter options to clear stuffy nose and help you breathe better.
  • Clears nasal congestion better than other decongestants like phenylephrine.
  • Can be helpful in relieving congestion-related headaches and pressure in your ears.
  • Available in regular and extended release forms.
Downsides and risks
AsteproSudafed
  • In older versions of the medicine, you can get a bitter taste in your mouth after spraying it into your nose.
  • Can cause nose bleeds if the spray nozzle is inserted into your nose wrongly.
  • Need a prescription to get Astepro (Azelastine).
  • It's good for 200 sprays, but there isn't a counter to help you keep track of sprays.
  • Pseudoephedrine (a decongestant) can make your heart race or make you feel anxious and restless.
  • It can affect the quality of your sleep, so you can't take it too close to going to bed.
  • Can raise blood pressure so check with your doctor before using it if you have high blood pressure or other heart conditions.
  • Sudafed (Pseudoephedrine) isn't as effective after using it for more than 4 days straight.
  • Need to show a photo ID to buy it in the drugstore and there is a limit on how much you can buy each visit.
Tips from our pharmacists for people taking the medication
AsteproSudafed
  • Starts working in 15 minutes.
  • Check with your doctor or pharmacist to make sure you know how to use this nose spray correctly.
  • Before using the spray for the first time, prime it until you see a fine mist.
  • Clear your nose before using the spray and breathe in slowly as you're spraying. After spraying, wait a few minutes before blowing your nose if needed.
  • Tilt your head forward to avoid getting a bitter taste while spraying the medicine.
  • Some people get a headache or feel drowsy and dizzy after using it.
  • Starts working in 30 minutes.
  • You need to show an ID to buy Sudafed (Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Don't take Sudafed (Pseudoephedrine) too close to bedtime since it can keep you awake.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • Talk to your doctor if your symptoms don't get better in 1 week.
Learn more
More about AsteproSide effectsReviews & ratingsAlternativesFDA package insert
More about SudafedSide effectsReviews & ratingsAlternativesFDA package insert