Compare Astepro vs. Zyrtec

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Astepro (Azelastine)

Prescription only

Zyrtec (Cetirizine)

Prescription or OTC
Relieves nasal allergy symptoms.

Astepro (Azelastine) is a prescription-only antihistamine nasal spray that can help with your allergy or nasal symptoms without exposing the rest of your body to the medicine.

Treats allergy symptoms.

Zyrtec (Cetirizine) is a once-daily allergy relief medication that won't make you feel too sleepy.

5.2/ 7 average rating with 1232 reviewsforZyrtec
Upsides
  • Astepro (Azelastine) lowers the number of nasal symptoms you'll get during allergy season.
  • Works faster than steroid nasal sprays and can be used as needed.
  • Most people don't have any side effects since it works in the nose and doesn't affect the rest of your body.
  • Won't make you feel sleepy.
  • Works just as well as steroid nasal sprays.
  • Zyrtec (Cetirizine) works as well as other antihistamines to treat sneezing and runny nose, but causes less sedation.
  • Works well to also treat hives and itchy skin.
  • Zyrtec (Cetirizine) is available over the counter without a prescription.
  • It comes as a tablet, liquid, and quick-dissolving tablet.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It's okay to take with most other medications because it has few drug interactions.
  • Most people don't get any side effects from Zyrtec (Cetirizine).
Downsides
  • In older versions of the medicine, you can get a bitter taste in your mouth after spraying it into your nose.
  • Can cause nose bleeds if the spray nozzle is inserted into your nose wrongly.
  • Need a prescription to get Astepro (Azelastine).
  • It's good for 200 sprays, but there isn't a counter to help you keep track of sprays.
  • Although it works fast, its effectiveness wears off for some people over time.
  • Zyrtec (Cetirizine) can be slightly more sedating than Allegra or Claritin.
  • Some people find that other more sedating antihistamines, like Benadryl, are more effective for them than Zyrtec (Cetirizine).
  • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
Used for
Dosage forms
  • Nasal spray
  • Pill
  • Liquid capsule
  • Dissolving tablet
  • Liquid
Price
Lowest price near you
$26.45
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Reviews
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1232 
76%
think this treatment is worth it
47%
think this treatment works well
7%
think this treatment is a hassle

Have you used Zyrtec (Cetirizine)?

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Side effects
4possible side effects
  • Rhinitis
    17%
  • Cough
    11%
  • Conjunctivitis
    5%
  • Asthma
    5%
See more detailed side effects
The Zyrtec (Cetirizine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

See more detailed risks and warnings
  • Increased side effects

    Age 65 or older

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Overdosage

    Current kidney disease

    ...and 1 more risk factors

See more detailed risks and warnings