Compare Astepro vs. Zyrtec

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Astepro
(azelastine)

Zyrtec
(cetirizine)

Relieves nasal allergy symptoms. Astepro (Azelastine) is a prescription-only antihistamine nasal spray that can help with your allergy or nasal symptoms without exposing the rest of your body to the medicine.Treats allergy symptoms. Zyrtec (Cetirizine) is a once-daily allergy relief medication that won't make you feel too sleepy.
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Prices and coupon for 1 (30ml of 137mcg/spray) nasal spray of azelastine
Coupons for
Prices and coupon for 30 (24 hour) tablets of cetirizine
Reviews & ratings
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Have you used Astepro (azelastine)?
Worth itNot sureNot worth it
Reviews for Zyrtec (cetirizine)
76%
-13% worse vs. Astepro (azelastine)
47%
-53% worse vs. Astepro (azelastine)
7%
+15% better vs. Astepro (azelastine)
1232 reviews
Have you used Zyrtec (cetirizine)?
Worth itNot sureNot worth it
Side effects
AsteproZyrtec
  • Bitter taste 19%
  • Headache 2%
  • Drowsiness 7%
  • Sore throat 1%
  • Nasal burning 2%
  • Nasal discomfort 4%
  • Paroxysmal sneezing 2%
  • Dry mouth 1%
  • Nausea 2%
More Astepro side effects »

We haven’t found good data for Zyrtec side effects.

FDA side effect reports for Zyrtec »
How it works
AsteproZyrtec
Astepro (Azelastine) is an antihistamine nasal spray. It works directly in your nose to block histamine, a chemical that causes runny nose, itching, and sneezing.Zyrtec (Cetirizine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. Antihistamines can also make you sleepy, but Zyrtec is a low-drowsiness version.
Type of medication
AsteproZyrtec
Prescription only
Prescription or OTC
Available as
AsteproZyrtec
  • Nasal spray
  • Pill
  • Liquid capsule
  • Dissolving tablet
  • Liquid
Used for
AsteproZyrtec
Risk factors for serious side effects
AsteproZyrtec
  • Taking with alcohol
  • Taking other medicines that make you less alert
Detailed Astepro (azelastine) risks & warnings »
    • Age 65 or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Current kidney disease
    • Current liver disease
    Detailed Zyrtec (cetirizine) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Price
    AsteproZyrtec
    • It's good for 200 sprays, but there isn't a counter to help you keep track of sprays.
    No price related info.
    Kidneys and liver
    AsteproZyrtec
    No kidneys and liver related info.
    • People with kidney or liver disease may need to take a lower dose of Zyrtec (Cetirizine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
    Sleep
    AsteproZyrtec
    • Won't make you feel sleepy.
    • Can make you feel sleepy, so take it at bedtime if needed.
    Upsides and benefits
    AsteproZyrtec
    • Astepro (Azelastine) lowers the number of nasal symptoms you'll get during allergy season.
    • Works faster than steroid nasal sprays and can be used as needed.
    • Most people don't have any side effects since it works in the nose and doesn't affect the rest of your body.
    • Won't make you feel sleepy.
    • Works just as well as steroid nasal sprays.
    • Zyrtec (Cetirizine) works as well as other antihistamines to treat sneezing and runny nose, but causes less sedation.
    • Works well to also treat hives and itchy skin.
    • Zyrtec (Cetirizine) is available over the counter without a prescription.
    • It comes as a tablet, liquid, and quick-dissolving tablet.
    • It can provide quick relief of allergy symptoms for both kids and adults.
    • It's okay to take with most other medications because it has few drug interactions.
    • Most people don't get any side effects from Zyrtec (Cetirizine).
    Downsides and risks
    AsteproZyrtec
    • In older versions of the medicine, you can get a bitter taste in your mouth after spraying it into your nose.
    • Can cause nose bleeds if the spray nozzle is inserted into your nose wrongly.
    • Need a prescription to get Astepro (Azelastine).
    • It's good for 200 sprays, but there isn't a counter to help you keep track of sprays.
    • Although it works fast, its effectiveness wears off for some people over time.
    • Zyrtec (Cetirizine) can be slightly more sedating than Allegra or Claritin.
    • Some people find that other more sedating antihistamines, like Benadryl, are more effective for them than Zyrtec (Cetirizine).
    • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
    Tips from our pharmacists for people taking the medication
    AsteproZyrtec
    • Starts working in 15 minutes.
    • Check with your doctor or pharmacist to make sure you know how to use this nose spray correctly.
    • Before using the spray for the first time, prime it until you see a fine mist.
    • Clear your nose before using the spray and breathe in slowly as you're spraying. After spraying, wait a few minutes before blowing your nose if needed.
    • Tilt your head forward to avoid getting a bitter taste while spraying the medicine.
    • Some people get a headache or feel drowsy and dizzy after using it.
    • Starts working in a few hours. Only take it once a day.
    • Can make you feel sleepy, so take it at bedtime if needed.
    • Avoid some of the side effects by drinking plenty of non-caffeinated liquids.
    • If you need to use it for more than a few weeks, talk with your doctor about trying a nasal steroid instead since it might work better for you long-term.
    • Using an antihistamine eye drop instead can also work better to treat itchy or watery eyes.
    Learn more
    More about AsteproSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Astepro (azelastine)?
    Worth itNot sureNot worth it
    More about ZyrtecSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zyrtec (cetirizine)?
    Worth itNot sureNot worth it