Compare Atenolol vs. Hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tenormin
(Atenolol)

Microzide
(Hydrochlorothiazide )

Lowers blood pressure and controls heart rate. Tenormin (Atenolol) is good for controlling chest pain and treating a heart attack. It has fewer side effects than other beta blockers. You need to take it on an empty stomach and you can't skip doses.Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
Filter group. All currently selected
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4.92Atenolol
Reviews for Tenormin (Atenolol)
58%
of people (All ages) say Tenormin (Atenolol) is worth it
48%
say it works well
16%
say it's a big hassle
457 reviews
Have you used Tenormin (Atenolol)?
Worth itNot sureNot worth it
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
-11% worse vs. Tenormin (Atenolol)
31%
-17% worse vs. Tenormin (Atenolol)
16%
Same vs. Tenormin (Atenolol)
139 reviews
Have you used Microzide (Hydrochlorothiazide (Hctz))?
Worth itNot sureNot worth it
Side effects
AtenololHydrochlorothiazide
  • Tiredness 13%
  • Dizziness 7%
  • Low mood disorder 3%
  • Cold arms and legs 7%
  • Fatigue 1%
  • Shortness of breath 2%
  • Light-headedness 3%
  • Leg pain 2%
  • Decreased energy 3%
More Atenolol side effects »

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
How it works
AtenololHydrochlorothiazide
Tenormin (Atenolol) is a selective beta blocker that works specifically on the heart by slowing down the heart and making the heart pump better.Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.
Type of medication
AtenololHydrochlorothiazide
Prescription only
Prescription only
Available as
AtenololHydrochlorothiazide
  • Pill
  • Pill
Used for
AtenololHydrochlorothiazide
Risk factors for serious side effects
AtenololHydrochlorothiazide
  • Suddenly stopping Tenormin (Atenolol)
    • Taking calcium channel blockers
    • Major surgery requiring anesthesia
    • Diabetes
      • Taking clonidine
      Detailed Tenormin (Atenolol) risks & warnings »
      • Current electrolyte imbalance
      • History of sulfa allergies
      • History of gout
      • Current kidney problems
        Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
        Pregnancy

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Kidneys and liver
        AtenololHydrochlorothiazide
        No kidneys and liver related info.
        • Requires routine blood tests to check kidney function.
        Upsides and benefits
        AtenololHydrochlorothiazide
        • A first-choice treatment to prevent chest pain (angina).
        • A first-choice treatment for heart attack recovery.
        • At lower doses, Tenormin (Atenolol) has fewer side effects than other beta blockers because it targets the heart and not other parts of the body.
        • Works well to get rid of extra fluids in your body through urination.
        • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
        • Lowers the risk of heart attack and stroke.
        • Good option if you have both high blood pressure and heart failure.
        • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
        • Most people have very few side effects.
        Downsides and risks
        AtenololHydrochlorothiazide
        • You need to take Tenormin (Atenolol) on an empty stomach.
        • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but it might not go away for others.
        • Not a first-choice treatment for high blood pressure unless you have heart disease. However, your doctor could add it to other medicines you're already if your blood pressure is still too high.
        • You can't miss or skip doses. If you stop Tenormin (Atenolol) suddenly, it can cause your blood pressure to go up really quickly, raising your risk of heart attack and stroke.
        • Tenormin (Atenolol) can hide symptoms of low blood sugar if you're diabetic.
        • Makes you urinate more often.
        • Doesn't work well in people with severe kidney problems.
        Tips from our pharmacists for people taking the medication
        AtenololHydrochlorothiazide
        • Lowers bad cholesterol and triglycerides. Raises good cholesterol.
        • Avoid grapefruit and grapefruit juice while taking this medicine.
        • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
        • Tell your doctor if you notice dark urine or yellowing in your eyes or skin.
        • Starts working in about 2 hours.
        • Makes you urinate more often, so avoid taking it at bedtime.
        • Can cause dizziness in the first few days.
        • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
        • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
        • Requires routine blood tests to check kidney function.
        Learn more
        More about AtenololSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Tenormin (Atenolol)?
        Worth itNot sureNot worth it
        More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Microzide (Hydrochlorothiazide (Hctz))?
        Worth itNot sureNot worth it