Compare Ativan vs. Anafranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ativan
(Lorazepam)

Anafranil
(Clomipramine)

Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.
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Reviews & ratings
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5.1035598705501615Ativan
Reviews for Ativan (Lorazepam)
70%
of people say Ativan (Lorazepam) is worth it
50%
say it works well
15%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
AtivanAnafranil

The Ativan FDA package insert doesn’t have numbers about how common side effects are.

More about Ativan side effects »
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Ejaculation failure 40%
  • Drowsiness 38%
  • Constipation 36%
  • Increased sweating 26%
  • Fatigue 21%
  • Loss of appetite 20%
  • Nausea 19%
More Anafranil side effects »
How it works
AtivanAnafranil
Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.
Type of medication
AtivanAnafranil
Anti-anxiety
Benzodiazepine
Prescription only
Antidepressant
Tricyclic antidepressant (TCA)
Prescription only
Available as
AtivanAnafranil
  • Pill
  • Liquid
  • Pill
Used for (click to learn more)
AtivanAnafranil
Risk factors for serious side effects
AtivanAnafranil
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
    • Alcohol
    • Taking other medicines that make you less alert
      Detailed Ativan (Lorazepam) risks & warnings »
      • Age 24 years or younger
      • Taking with alcohol
      • Taking other medicines that make you less alert
      • Using other medications that affect serotonin
      • History of seizure
      • Taking other medicines that increase seizure risk
      • Alcoholism
      • Stopping Anafranil (Clomipramine) suddenly
      • Age 65 years or older
      • History of heart disease
      • Older age
      • Electrolyte imbalance
      Detailed Anafranil (Clomipramine) risks & warnings »
      Pregnancy category
      AtivanAnafranil
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
      • Not safe to use with alcohol.
      No specific alcohol-related info.
      Food
      No specific food-related info.
      • Take it with food and/or at bedtime to decrease the potential side effects.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.
      • Can cause sexual performance problems in men.
      Sleep
      • Can cause memory problems, drowsiness, dizziness, and confusion.
      • Can cause temporary dizziness and drowsiness.
      • Stopping Ativan (Lorazepam) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and muscle pain or burning. Withdrawal symptoms can last 6 weeks or longer. Work with your doctor to gradually reduce your dose.
      • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
      • Can help you sleep.
      • Stopping Anafranil (Clomipramine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
      Weight
      No specific weight-related info.
      • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
      Upsides and benefits
      AtivanAnafranil
      • Effective at relieving short-term anxiety and sleeplessness.
      • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
      • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
      • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
      • Helps some people see improvements in their mood.
      • Can help you sleep.
      • Lower risk of causing heart problems compared to other medicine in this class.
      Downsides and risks
      AtivanAnafranil
      • Can cause memory problems, drowsiness, dizziness, and confusion.
      • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
      • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
      • Most people find that it gets less effective over time.
      • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
      • Can cause sexual performance problems in men.
      • Increases the risk of falls, especially when used in the elderly.
      Tips from our pharmacists for people taking the medication
      AtivanAnafranil
      • Good for short-term relief of anxiety symptoms.
      • Starts working in 45 minutes when swallowed.
      • Starts working in 10 to 20 minutes when dissolved under your tongue.
      • Can cause temporary dizziness and drowsiness.
      • Addictive. Long-term use can cause dependence or abuse.
      • Not safe to use with alcohol.
      • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
      • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
      • Take it with food and/or at bedtime to decrease the potential side effects.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
      Learn more
      More about AtivanSide effectsReviews & ratingsAlternativesFDA package insert
      More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert