Compare Ativan vs. chlordiazepoxide / amitriptyline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ativan
(lorazepam)

Limbitrol
(chlordiazepoxide / amitriptyline)

Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.Treats anxiety and depression. While Limbitrol (chlordiazepoxide / amitriptyline) as a combination can be used to treat both anxiety and depression, other medicines are considered first choice because chlordiazepoxide can be potentially addicting.
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Prices and coupon for 60 (0.5mg) tablets of lorazepam
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Prices and coupon for 60 (5mg/12.5mg) tablets of chlordiazepoxide / amitriptyline
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.14Ativan
Reviews for Ativan (lorazepam)
71%
of people (All ages) say Ativan (lorazepam) is worth it
51%
say it works well
15%
say it's a big hassle
642 reviews
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it

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Have you used Limbitrol (chlordiazepoxide / amitriptyline)?
Worth itNot sureNot worth it
Side effects
Ativanchlordiazepoxide / amitriptyline
  • Relaxation or sleepiness 16%
  • Dizziness 7%
  • Weakness 4%
  • Unsteadiness 3%
More Ativan side effects »

The chlordiazepoxide / amitriptyline FDA package insert doesn’t have numbers about how common side effects are.

More about chlordiazepoxide / amitriptyline side effects »
How it works
Ativanchlordiazepoxide / amitriptyline
Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.Limbitrol (chlordiazepoxide / amitriptyline) is a combination of 2 medicines. Chlordiazepoxide is a benzodiazepine, and it calms activity in a part of the brain responsible for emotional responses. Amitriptyline is a tricyclic antidepressant, and it raises the amount of norepinephrine and serotonin in the brain, which can improve mood.
Type of medication
Ativanchlordiazepoxide / amitriptyline
Prescription only
Prescription only
Available as
Ativanchlordiazepoxide / amitriptyline
  • Pill
  • Liquid
  • Pill
Used for
Ativanchlordiazepoxide / amitriptyline
  • Anxiety And Depression
Risk factors for serious side effects
Ativanchlordiazepoxide / amitriptyline
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
    • Alcohol
    • Taking other medicines that make you less alert
      Detailed Ativan (lorazepam) risks & warnings »
      • People under age 24
          • Glaucoma
          • Heart disease
          • Drinking alcohol or taking narcotics
          Detailed Limbitrol (chlordiazepoxide / amitriptyline) risks & warnings »
          Pregnancy

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Interactions
          Ativanchlordiazepoxide / amitriptyline
          • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
          No interactions related info.
          Alcohol
          Ativanchlordiazepoxide / amitriptyline
          • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
          • Not safe to use with alcohol.
          • Don't drink alcohol or take any narcotics while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can slow your breathing.
          • Don't drink alcohol or take narcotics, tranquilizers, or antihistamines if you're taking Limbitrol (chlordiazepoxide / amitriptyline). This can slow down your breathing. Talk to your doctor if this is a problem.
          Sleep
          Ativanchlordiazepoxide / amitriptyline
          • Can cause memory problems, drowsiness, dizziness, and confusion.
          • Can cause temporary dizziness and drowsiness.
          • Limbitrol (chlordiazepoxide / amitriptyline) can make you sleepy and unable to focus, so don't drive or do anything requiring concentration for a few hours after taking it until you know how it affects you. This can be worse if you drink alcohol or take narcotics.
          Upsides and benefits
          Ativanchlordiazepoxide / amitriptyline
          • Effective at relieving short-term anxiety and sleeplessness.
          • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
          • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
          • Limbitrol (chlordiazepoxide / amitriptyline) is available as a generic.
          • Limbitrol (chlordiazepoxide / amitriptyline) works faster than amitriptyline alone.
          Downsides and risks
          Ativanchlordiazepoxide / amitriptyline
          • Can cause memory problems, drowsiness, dizziness, and confusion.
          • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
          • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
          • Most people find that it gets less effective over time.
          • Limbitrol (chlordiazepoxide / amitriptyline) is only available in certain strengths, so it can be difficult to customize a dose that treats both anxiety and depression.
          • Limbitrol (chlordiazepoxide / amitriptyline) contains chlordiazepoxide, which can be potentially addicting.
          • You might not notice any changes in your mood until you've been taking Limbitrol (chlordiazepoxide / amitriptyline) for several weeks.
          • Amitriptyline alone is considered a better treatment for anxiety and depression than Limbitrol (chlordiazepoxide / amitriptyline).
          • Other medicines are considered first choice for treating anxiety and depression over Limbitrol (chlordiazepoxide / amitriptyline).
          Tips from our pharmacists for people taking the medication
          Ativanchlordiazepoxide / amitriptyline
          • Good for short-term relief of anxiety symptoms.
          • Starts working in 45 minutes when swallowed.
          • Starts working in 10 to 20 minutes when dissolved under your tongue.
          • Can cause temporary dizziness and drowsiness.
          • Addictive. Long-term use can cause dependence or abuse.
          • Not safe to use with alcohol.
          • Don't drink alcohol or take any narcotics while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can slow your breathing.
          • If you've taken Limbitrol (chlordiazepoxide / amitriptyline) for an extended amount of time, don't stop taking it suddenly without talking to your doctor first. It can be very dangerous.
          • Don't drive or do anything requiring concentration while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can make you sleepy. This can be worse if you drink alcohol or take narcotics.
          • You might not notice changes in your mood until you've taken Limbitrol (chlordiazepoxide / amitriptyline) for at least a few weeks.
          • If you're being switched to Limbitrol (chlordiazepoxide / amitriptyline) from a group of medicines called monoamine oxidase inhibitors (MAOI), you should wait at least 14 days before you start.
          Learn more
          More about AtivanSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Ativan (lorazepam)?
          Worth itNot sureNot worth it
          More about chlordiazepoxide / amitriptylineSide effectsAlternativesFDA package insert
          Have you used Limbitrol (chlordiazepoxide / amitriptyline)?
          Worth itNot sureNot worth it