Compare Ativan vs. chlordiazepoxide / amitriptyline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ativan (lorazepam)

Prescription only
Helps you relax.

Ativan (lorazepam) is an effective medicine for occasional or short-term anxiety. It's less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.

5.1/ 7 average rating with 642 reviewsforAtivan
Treats anxiety and depression.

While Limbitrol (chlordiazepoxide / amitriptyline) as a combination can be used to treat both anxiety and depression, other medicines are considered first choice because chlordiazepoxide can be potentially addicting.

Upsides
  • Effective at relieving short-term anxiety.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in.
  • Less likely to have drug interactions compared to other drugs like it, so it might be a better option if you're taking multiple medications.
  • Limbitrol (chlordiazepoxide / amitriptyline) is available as a generic.
  • Limbitrol (chlordiazepoxide / amitriptyline) works faster than amitriptyline alone.
Downsides
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment or for people who've had problems with drug or alcohol abuse.
  • Compared to other similar medicines, Ativan (lorazepam) is more likely to cause withdrawal if you take it for a long time and then suddenly stop.
  • Most people find that Ativan (lorazepam) gets less effective over time.
  • Limbitrol (chlordiazepoxide / amitriptyline) is only available in certain strengths, so it can be difficult to customize a dose that treats both anxiety and depression.
  • Limbitrol (chlordiazepoxide / amitriptyline) contains chlordiazepoxide, which can be potentially addicting.
  • You might not notice any changes in your mood until you've been taking Limbitrol (chlordiazepoxide / amitriptyline) for several weeks.
  • Amitriptyline alone is considered a better treatment for anxiety and depression than Limbitrol (chlordiazepoxide / amitriptyline).
  • Other medicines are considered first choice for treating anxiety and depression over Limbitrol (chlordiazepoxide / amitriptyline).
Used for
  • Anxiety and depression
Dosage forms
  • Pill
  • Liquid
  • Injection
  • Pill
Price
Lowest price near you
$9.17
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$38.43
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Reviews
642 
71%
think this treatment is worth it
51%
think this treatment works well
15%
think this treatment is a hassle

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Side effects
4possible side effects
  • Sleepiness
    16%
  • Dizziness
    7%
  • Weakness
    4%
  • Unsteadiness
    3%
See more detailed side effects
The Limbitrol (chlordiazepoxide / amitriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Severe sedation with opioid use

    Taking with opioids

  • Tolerance and dependence

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Withdrawal

    Long-term use

  • Driving impairment

    Alcohol

    ...and 1 more risk factors

See more detailed risks and warnings
  • Higher risk of suicide

    People under age 24

  • Vision changes

    Glaucoma

  • Changes in heartbeat, heart attack, or stroke

    Heart disease

  • Breathing problems

    Alcohol

    ...and 1 more risk factors

  • Drowsiness and sleepiness

    Drinking alcohol or taking narcotics

See more detailed risks and warnings