Compare Ativan vs. desipramine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ativan
(lorazepam)

Norpramin
(desipramine)

Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.
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Coupons for Ativan
Best available price for 60 (0.5mg) tablets of ativan
Coupons for desipramine
Best available price for 30 (25mg) tablets of desipramine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.14Ativan
Reviews for Ativan
71%
of people (All ages) say Ativan is worth it
51%
say it works well
15%
say it's a big hassle
642 reviews
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
Side effects
Ativandesipramine
  • Relaxation or sleepiness 16%
  • Dizziness 7%
  • Weakness 4%
  • Unsteadiness 3%
More Ativan side effects »

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »
How it works
Ativandesipramine
Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.
Type of medication
Ativandesipramine
Prescription onlyPrescription only
Available as
Ativandesipramine
  • Pill
  • Liquid
  • Pill
Used for
Ativandesipramine
Risk factors for serious side effects
Ativandesipramine
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Alcohol
Detailed Ativan (lorazepam) risks & warnings »
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Norpramin (desipramine) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
Ativandesipramine
  • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
No interactions related info.
Alcohol
Ativandesipramine
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Not safe to use with alcohol.
No alcohol related info.
Sleep
Ativandesipramine
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can cause temporary dizziness and drowsiness.
No sleep related info.
Upsides and benefits
Ativandesipramine
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
Downsides and risks
Ativandesipramine
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
  • Most people find that it gets less effective over time.
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
Tips from our pharmacists for people taking the medication
Ativandesipramine
  • Good for short-term relief of anxiety symptoms.
  • Starts working in 45 minutes when swallowed.
  • Starts working in 10 to 20 minutes when dissolved under your tongue.
  • Can cause temporary dizziness and drowsiness.
  • Addictive. Long-term use can cause dependence or abuse.
  • Not safe to use with alcohol.
  • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
  • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
  • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
  • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
Learn more
More about AtivanSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it
More about desipramineSide effectsAlternativesFDA package insert
Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it