Compare Ativan vs. Unisom

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ativan
(lorazepam)

Unisom Sleeptabs
(doxylamine)

Helps you relax. Ativan (lorazepam) is an effective medicine for occasional or short-term anxiety. It's less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.Treats allergy symptoms and helps you sleep. Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.14Ativan
Reviews for Ativan
71%
of people (All ages) say Ativan is worth it
51%
say it works well
15%
say it's a big hassle
642 reviews
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it
Reviews for Unisom
58%
+13% better vs. Ativan
32%
+19% better vs. Ativan
11%
-4% worse vs. Ativan
585 reviews
Have you used Unisom Sleeptabs (doxylamine)?
Worth itNot sureNot worth it
Side effects
AtivanUnisom
  • Sleepiness 16%
  • Dizziness 7%
  • Weakness 4%
  • Unsteadiness 3%
More Ativan side effects »

We haven’t found good data for Unisom side effects.

FDA side effect reports for Unisom »
How it works
AtivanUnisom
Ativan (lorazepam) is a fast-acting benzodiazepine. It affects areas of the brain that help calm you down. This reduces anxiety and can cause sleepiness.Unisom Sleeptabs (Doxylamine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.
Type of medication
AtivanUnisom
Prescription onlyPrescription or OTC
Available as
AtivanUnisom
  • Pill
  • Liquid
  • Injection
  • Pill
  • Chewable tablet
  • Liquid
Used for
AtivanUnisom
Risk factors for serious side effects
AtivanUnisom
  • Taking with opioids
  • Taking more than the prescribed dose
  • Taking Ativan (lorazepam) for longer than 4 weeks
  • History of drug abuse
  • Long-term use
Detailed Ativan (lorazepam) risks & warnings »
  • Using other drugs with similar ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years or younger
Detailed Unisom Sleeptabs (doxylamine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
AtivanUnisom
  • Less likely to have drug interactions compared to other drugs like it, so it might be a better option if you're taking multiple medications.
No interactions related info.
Alcohol
AtivanUnisom
  • Not safe to use with alcohol.
  • Can be habit-forming, so it's not typically used for long-term treatment or for people who've had problems with drug or alcohol abuse.
  • Don't take it with alcohol or other drugs that make you sleepy.
  • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
Sleep
AtivanUnisom
  • Can cause temporary dizziness and drowsiness.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Not habit-forming like other sleep aids can be.
Upsides and benefits
AtivanUnisom
  • Effective at relieving short-term anxiety.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in.
  • Less likely to have drug interactions compared to other drugs like it, so it might be a better option if you're taking multiple medications.
  • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
  • Has fewer side effects than prescription sleep aid medications.
  • Available over the counter without a prescription.
  • Not habit-forming like other sleep aids can be.
Downsides and risks
AtivanUnisom
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment or for people who've had problems with drug or alcohol abuse.
  • Compared to other similar medicines, Ativan (lorazepam) is more likely to cause withdrawal if you take it for a long time and then suddenly stop.
  • Most people find that Ativan (lorazepam) gets less effective over time.
  • Shouldn't be used unless you have a full night to sleep.
  • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
  • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
  • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
Tips from our pharmacists for people taking the medication
AtivanUnisom
  • Can cause temporary dizziness and drowsiness.
  • Take only as much as your doctor prescribes. Taking more than directed or taking this for a long time can cause you to become dependent on it.
  • Not safe to use with alcohol.
  • Use caution or avoid use in older adults.
  • Starts working in 30 minutes.
  • Unisom Sleeptabs (Doxylamine) makes you tired, so take it before you go to sleep.
  • Don't take it with alcohol or other drugs that make you sleepy.
  • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
  • Unisom comes in two different generic forms, doxylamine (Unisom SleepTabs) and diphenhydramine (other Unisom products). Both are antihistamines that help you sleep.
Learn more
More about AtivanSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it
More about UnisomSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Unisom Sleeptabs (doxylamine)?
Worth itNot sureNot worth it