Compare Ativan vs. Unisom

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ativan
(lorazepam)

Unisom Sleeptabs
(doxylamine)

Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.Treats allergy symptoms and helps you sleep. Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.
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Prices and coupon for 60 (0.5mg) tablets of lorazepam
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Prices and coupon for 30 (25mg) tablets of doxylamine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.14Ativan
Reviews for Ativan (lorazepam)
71%
of people (All ages) say Ativan (lorazepam) is worth it
51%
say it works well
15%
say it's a big hassle
642 reviews
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it
Reviews for Unisom Sleeptabs (doxylamine)
58%
-13% worse vs. Ativan (lorazepam)
32%
-19% worse vs. Ativan (lorazepam)
11%
+4% better vs. Ativan (lorazepam)
585 reviews
Have you used Unisom Sleeptabs (doxylamine)?
Worth itNot sureNot worth it
Side effects
AtivanUnisom
  • Relaxation or sleepiness 16%
  • Dizziness 7%
  • Weakness 4%
  • Unsteadiness 3%
More Ativan side effects »

We haven’t found good data for Unisom side effects.

FDA side effect reports for Unisom »
How it works
AtivanUnisom
Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.Unisom Sleeptabs (Doxylamine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.
Type of medication
AtivanUnisom
Prescription only
Prescription or OTC
Available as
AtivanUnisom
  • Pill
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
Used for
AtivanUnisom
Risk factors for serious side effects
AtivanUnisom
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
    • Alcohol
    • Taking other medicines that make you less alert
      Detailed Ativan (lorazepam) risks & warnings »
      • Using other drugs with similar ingredients
      • Age 65 years or older
      • Taking with alcohol
      • Taking other medicines that make you less alert
      • Children age 6 years or younger
      • Enlarged prostate
      • History of bladder problems
      • Glaucoma
      • Nursing mothers
      Detailed Unisom Sleeptabs (doxylamine) risks & warnings »
      Pregnancy

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Interactions
      AtivanUnisom
      • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
      No interactions related info.
      Alcohol
      AtivanUnisom
      • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
      • Not safe to use with alcohol.
      • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
      • Don't take it with alcohol or other drugs that make you sleepy.
      Sleep
      AtivanUnisom
      • Can cause memory problems, drowsiness, dizziness, and confusion.
      • Can cause temporary dizziness and drowsiness.
      • Not habit-forming like other sleep aids can be.
      Upsides and benefits
      AtivanUnisom
      • Effective at relieving short-term anxiety and sleeplessness.
      • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
      • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
      • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
      • Has fewer side effects than prescription sleep aid medications.
      • Available over the counter without a prescription.
      • Not habit-forming like other sleep aids can be.
      Downsides and risks
      AtivanUnisom
      • Can cause memory problems, drowsiness, dizziness, and confusion.
      • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
      • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
      • Most people find that it gets less effective over time.
      • Shouldn't be used unless you have a full night to sleep.
      • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
      • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
      • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
      Tips from our pharmacists for people taking the medication
      AtivanUnisom
      • Good for short-term relief of anxiety symptoms.
      • Starts working in 45 minutes when swallowed.
      • Starts working in 10 to 20 minutes when dissolved under your tongue.
      • Can cause temporary dizziness and drowsiness.
      • Addictive. Long-term use can cause dependence or abuse.
      • Not safe to use with alcohol.
      • Starts working in 30 minutes.
      • Unisom Sleeptabs (Doxylamine) makes you tired, so take it before you go to sleep.
      • Don't take it with alcohol or other drugs that make you sleepy.
      • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
      • Unisom comes in two different generic forms, doxylamine (Unisom SleepTabs) and diphenhydramine (other Unisom products). Both are antihistamines that help you sleep.
      Learn more
      More about AtivanSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Ativan (lorazepam)?
      Worth itNot sureNot worth it
      More about UnisomSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Unisom Sleeptabs (doxylamine)?
      Worth itNot sureNot worth it