Compare Atorvastatin vs. Vytorin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lipitor
(Atorvastatin)

Vytorin
(Ezetimibe / Simvastatin)

Lowers cholesterol. Lipitor (Atorvastatin) is a good medication to improve your cholesterol. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.16020482809071Atorvastatin
Reviews for Lipitor (Atorvastatin)
63%
of people say Lipitor (Atorvastatin) is worth it
51%
say it works well
13%
say it's a big hassle
Reviews for Vytorin (Ezetimibe / Simvastatin)
52%
11% vs. Lipitor (Atorvastatin)
36%
15% vs. Lipitor (Atorvastatin)
19%
6% vs. Lipitor (Atorvastatin)
Side effects
AtorvastatinVytorin
  • Diarrhea 8%
  • Common cold 5%
  • Muscle pain 5%
  • Joint pain 5%
  • Nausea 3%
  • Pain in extremity 3%
  • Urinary tract infection 2%
  • Sleep difficulty 2%
  • Muscle spasms 2%
  • Throat pain 2%
More Atorvastatin side effects »
  • Unexplained muscle pain or weakness 1%
  • Ear, nose, or throat infection 1%
  • Pain in extremity 1%
  • Flu 1%
More Vytorin side effects »
How it works
AtorvastatinVytorin
Lipitor (Atorvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.
Type of medication
AtorvastatinVytorin
Cholesterol-lowering
Statin
Prescription only
Cholesterol-lowering
Cholesterol inhibitor
Statin
Prescription only
Available as
AtorvastatinVytorin
  • Pill
  • Pill
Used for (click to learn more)
AtorvastatinVytorin
Risk factors for serious side effects
AtorvastatinVytorin
    • Heavy alcohol use
    • Prior history of chronic liver disease
    • Pregnancy
        Detailed Lipitor (Atorvastatin) risks & warnings »
        • Asian patients taking high-dose niacin
        • Past history of liver disease
        • heavy alcohol use
        • Diabetes
            • Pregnancy
            Detailed Vytorin (Ezetimibe / Simvastatin) risks & warnings »
            Pregnancy category
            AtorvastatinVytorin
            XFDA pregnancy category (Unsafe)

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            See the FDA package insert
            XFDA pregnancy category (Unsafe)

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            See the FDA package insert
            Alcohol
            • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
            • People who take Vytorin (Ezetimibe / Simvastatin) have reported liver damage, especially if taken with statins or if you drink large amounts of alcohol. This has been rare. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
            Food
            No specific food-related info.No specific food-related info.
            Kidneys and liver
            • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
            • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
            • People on Lipitor (Atorvastatin) have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
            • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            No specific weight-related info.No specific weight-related info.
            Upsides and benefits
            AtorvastatinVytorin
            • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
            • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
            • One of the strongest cholesterol-lowering statin medications.
            • A good option for people who have high cholesterol and diabetes.
            • A 2-in-1 cholesterol-lowering combination medicine.
            • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
            Downsides and risks
            AtorvastatinVytorin
            • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
            • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
            • Eating a lot of grapefruit can raise your risk of liver damage.
            • Not safe to use if you're pregnant.
            • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
            • There's no generic available, so it can be expensive.
            Tips from our pharmacists for people taking the medication
            AtorvastatinVytorin
            • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
            • Tell your doctor if you develop sudden muscle pain, fever or weakness.
            • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
            • Avoid grapefruit and grapefruit juice while taking this medicine.
            • Take it in the evening.
            • Can cause headaches or diarrhea.
            • Call your doctor if you develop muscle pain.
            • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
            • Avoid grapefruit and grapefruit juice while taking this medicine.
            Learn more
            More about AtorvastatinSide effectsReviews & ratingsAlternativesFDA package insert
            More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert