Compare Atorvastatin vs. Vytorin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lipitor
(atorvastatin)

Vytorin
(ezetimibe / simvastatin)

Lowers cholesterol. Lipitor (atorvastatin) improves your cholesterol levels and is a common first treatment for people with high cholesterol or heart disease.Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.16Atorvastatin
Reviews for Atorvastatin
63%
of people (All ages) say Atorvastatin is worth it
51%
say it works well
13%
say it's a big hassle
1377 reviews
Have you used Lipitor (atorvastatin)?
Worth itNot sureNot worth it
Reviews for Vytorin
53%
+10% better vs. Atorvastatin
36%
+15% better vs. Atorvastatin
19%
+6% better vs. Atorvastatin
Have you used Vytorin (ezetimibe / simvastatin)?
Worth itNot sureNot worth it
Side effects
AtorvastatinVytorin
  • Diarrhea 1%
  • Indigestion 1%
  • Muscle spasms 1%
  • Muscle pain 1%
More Atorvastatin side effects »
  • Headache 1%
  • Any side effect 3%
  • Muscle pain 4%
  • Ear, nose, or throat infection 4%
  • Increased alt 4%
  • Diarrhea 3%
  • Flu 1%
  • Pain in extremity 1%
  • Unexplained muscle pain or weakness 1%
More Vytorin side effects »
How it works
AtorvastatinVytorin
Lipitor (atorvastatin) is a cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.
Type of medication
AtorvastatinVytorin
Prescription onlyPrescription only
Available as
AtorvastatinVytorin
  • Pill
  • Pill
Used for
AtorvastatinVytorin
Risk factors for serious side effects
AtorvastatinVytorin
  • Heavy alcohol use
  • Prior history of chronic liver disease
  • Pregnancy
  • History of hemorrhagic strokes
Detailed Lipitor (atorvastatin) risks & warnings »
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
  • Pregnancy
Detailed Vytorin (ezetimibe / simvastatin) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Alcohol
AtorvastatinVytorin
  • You're at higher risk for these side effects if you are a female, are 65 years or older, or drink more than two alcoholic drinks a day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
No alcohol related info.
Kidneys and liver
AtorvastatinVytorin
  • People on Lipitor (atorvastatin) have reported muscle pain, which may lead to muscle and kidney damage. This is more likely to happen if you're older and you're taking higher doses of Lipitor (atorvastatin). If you suddenly feel muscle pain or weakness and you haven't been exercising, stop taking Lipitor (atorvastatin) and talk to your doctor right away.
  • Liver damage has been reported in people who take Lipitor (atorvastatin). If you notice dark urine or yellowing of your eyes or skin, talk to your doctor. Your doctor might run blood tests to check your liver.
  • Statins such as Lipitor (atorvastatin) can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, or liver damage. Some people need to stop taking this medicine if these problems occur.
  • Eating grapefruit or drinking grapefruit juice can raise your risk of liver damage while taking Lipitor (atorvastatin).
  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
Pain
AtorvastatinVytorin
  • Tell your doctor if you suddenly feel severe muscle pain, fever, or weakness.
No pain related info.
Upsides and benefits
AtorvastatinVytorin
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats), and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Lipitor (atorvastatin) can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • It's one of the strongest cholesterol-lowering statin medications.
  • Lipitor (atorvastatin) is a good option for people who have high cholesterol and diabetes.
  • It's available as a generic drug and can be used in combination with other cholesterol lowering drugs.
  • A 2-in-1 cholesterol-lowering combination medicine.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
Downsides and risks
AtorvastatinVytorin
  • Statins such as Lipitor (atorvastatin) can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, or liver damage. Some people need to stop taking this medicine if these problems occur.
  • You're at higher risk for these side effects if you are a female, are 65 years or older, or drink more than two alcoholic drinks a day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
  • Eating grapefruit or drinking grapefruit juice can raise your risk of liver damage while taking Lipitor (atorvastatin).
  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
  • There's no generic available, so it can be expensive.
Tips from our pharmacists for people taking the medication
AtorvastatinVytorin
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
  • Don't eat grapefruit or drink grapefruit juice while taking this medicine.
  • Tell your doctor if you suddenly feel severe muscle pain, fever, or weakness.
  • Also tell your doctor if you have dark urine or if you notice a yellow tint in your eyes or skin.
  • Lipitor (atorvastatin) isn't safe to use if you're pregnant.
  • Take it in the evening.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Can cause headaches or diarrhea.
  • Call your doctor if you develop muscle pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
Learn more
More about AtorvastatinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lipitor (atorvastatin)?
Worth itNot sureNot worth it
More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vytorin (ezetimibe / simvastatin)?
Worth itNot sureNot worth it