Compare Atorvastatin vs. Zetia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lipitor
(atorvastatin)

Zetia
(ezetimibe)

Lowers cholesterol. Lipitor (atorvastatin) improves your cholesterol levels and is a common first treatment for people with high cholesterol or heart disease.Lowers cholesterol. Zetia can improve your cholesterol, but it doesn't reduce heart attacks or heart disease, and it's expensive compared to other cholesterol-lowering medicines.
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Prices and coupon for 30 (20mg) tablets of atorvastatin
Coupons for
Prices and coupon for 30 (10mg) tablets of ezetimibe
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.16Atorvastatin
Reviews for Lipitor (atorvastatin)
63%
of people (All ages) say Lipitor (atorvastatin) is worth it
51%
say it works well
13%
say it's a big hassle
1377 reviews
Have you used Lipitor (atorvastatin)?
Worth itNot sureNot worth it
Reviews for Zetia (ezetimibe)
42%
-21% worse vs. Lipitor (atorvastatin)
34%
-17% worse vs. Lipitor (atorvastatin)
21%
-8% worse vs. Lipitor (atorvastatin)
128 reviews
Have you used Zetia (ezetimibe)?
Worth itNot sureNot worth it
Side effects
AtorvastatinZetia
  • Diarrhea 1%
  • Indigestion 1%
  • Muscle spasms 1%
  • Muscle pain 1%
More Atorvastatin side effects »
  • Ear, nose, or throat infection 1%
  • Sinus inflammation 1%
  • Arthtralgia 1%
More Zetia side effects »
How it works
AtorvastatinZetia
Lipitor (atorvastatin) is a cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Zetia is a cholesterol-lowering medicine. It prevents cholesterol absorption in your intestines, lowers the amount of cholesterol stored in your liver, and helps your body process cholesterol.
Type of medication
AtorvastatinZetia
Prescription only
Prescription only
Available as
AtorvastatinZetia
  • Pill
  • Pill
Used for
AtorvastatinZetia
Risk factors for serious side effects
AtorvastatinZetia
    • Heavy alcohol use
    • Prior history of chronic liver disease
    • Pregnancy
    • History of hemorrhagic strokes
      Detailed Lipitor (atorvastatin) risks & warnings »
        • Taking Zetia (Ezetimibe) with statins
        • Past history of liver disease
        • Taking Zetia (Ezetimibe) with statins
        Detailed Zetia (ezetimibe) risks & warnings »
        Pregnancy

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        AtorvastatinZetia
        • You're at higher risk for these side effects if you are a female, are 65 years or older, or drink more than two alcoholic drinks a day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
        No alcohol related info.
        Kidneys and liver
        AtorvastatinZetia
        • Statins such as Lipitor (atorvastatin) can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, or liver damage. Some people need to stop taking this medicine if these problems occur.
        • Eating grapefruit or drinking grapefruit juice can raise your risk of liver damage while taking Lipitor (atorvastatin).
        • People on Lipitor (atorvastatin) have reported muscle pain, which may lead to muscle and kidney damage. This is more likely to happen if you're older and you're taking higher doses of Lipitor (atorvastatin). If you suddenly feel muscle pain or weakness and you haven't been exercising, stop taking Lipitor (atorvastatin) and talk to your doctor right away.
        • Liver damage has been reported in people who take Lipitor (atorvastatin). If you notice dark urine or yellowing of your eyes or skin, talk to your doctor. Your doctor might run blood tests to check your liver.
        • Reports of liver disease have been reported in people who take Zetia (Ezetimibe), especially if taken with statins. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
        Pain
        AtorvastatinZetia
        • Tell your doctor if you suddenly feel severe muscle pain, fever, or weakness.
        No pain related info.
        Upsides and benefits
        AtorvastatinZetia
        • Lowers "bad" cholesterol (LDL) and triglycerides (fats), and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
        • Lipitor (atorvastatin) can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
        • It's one of the strongest cholesterol-lowering statin medications.
        • Lipitor (atorvastatin) is a good option for people who have high cholesterol and diabetes.
        • It's available as a generic drug and can be used in combination with other cholesterol lowering drugs.
        • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
        • Can be used with other medicines to improve cholesterol.
        • Available in a combination pill with simvastatin.
        Downsides and risks
        AtorvastatinZetia
        • Statins such as Lipitor (atorvastatin) can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, or liver damage. Some people need to stop taking this medicine if these problems occur.
        • You're at higher risk for these side effects if you are a female, are 65 years or older, or drink more than two alcoholic drinks a day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
        • Eating grapefruit or drinking grapefruit juice can raise your risk of liver damage while taking Lipitor (atorvastatin).
        • Doesn't lower triglycerides (fats).
        • Hasn't been shown to lower the risk of heart attacks or heart disease.
        • By itself, Zetia is not as effective as statins for improving cholesterol.
        • There's no generic available, so it can be expensive.
        Tips from our pharmacists for people taking the medication
        AtorvastatinZetia
        • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
        • Don't eat grapefruit or drink grapefruit juice while taking this medicine.
        • Tell your doctor if you suddenly feel severe muscle pain, fever, or weakness.
        • Also tell your doctor if you have dark urine or if you notice a yellow tint in your eyes or skin.
        • Lipitor (atorvastatin) isn't safe to use if you're pregnant.
        • Lowers bad cholesterol, and raises good cholesterol.
        • Tell your doctor if you develop bone or muscle pain.
        • Can be used with other medications to lower cholesterol.
        • May cause diarrhea or raise your chance of getting colds.
        Learn more
        More about AtorvastatinSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Lipitor (atorvastatin)?
        Worth itNot sureNot worth it
        More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zetia (ezetimibe)?
        Worth itNot sureNot worth it