Compare Atripla vs. Viread

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Atripla
(Efavirenz / Emtricitabine / Tenofovir)

Viread
(Tenofovir)

Treats HIV infection. Atripla (Efavirenz / Emtricitabine / Tenofovir) is effective at treating HIV infection and it’s easier to remember to take just one pill instead of three separate medicines.Works with other medicines to treat HIV infection. Also treats Hepatitis B Virus. tenofovir can be a good choice to take within the Nucleoside Reverse Transcriptase Inhibitor (NRTI) drug class. It may not be the best choice though for people with kidney problems.
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Reviews & ratings
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Side effects
AtriplaViread

The Atripla FDA package insert doesn’t have numbers about how common side effects are.

More about Atripla side effects »

We haven’t found good data for Viread side effects.

FDA side effect reports for Viread »
How it works
AtriplaViread
Atripla (Efavirenz / Emtricitabine / Tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs: tenofovir and emtricitabine (two nucleoside reverse transcriptase inhibitors) and efavirenz (a non-nucleoside reverse transcriptase inhibitor). It prevents the HIV-1 virus from multiplying and producing new viruses.tenofovir stops the replication of the human immunodeficiency virus (HIV) within important cells of the body by preventing the virus from taking over normal functions of the cell for its own purposes.
Type of medication
AtriplaViread
Antiretroviral
Non-nucleoside reverse transcriptase inhibitor (NNRTI)
Antiretrovira
Nucleoside reverse transcriptase inhibitor (NRTI)
Antiretroviral
Nucleoside reverse transcriptase inhibitor (NRTI)
Prescription only
Coming soon.
Available as
AtriplaViread
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
AtriplaViread
  • HIV infection
Risk factors for serious side effects
AtriplaViread
  • History of mental illness.
  • History of using recreational drugs.
  • Starting Atripla (Efavirenz / Emtricitabine / Tenofovir) for the first few weeks.
  • Taking alcohol or other drugs that also affect your nervous system.
  • Prior bone fractures
  • Osteoporosis
  • Women
  • Obesity
  • Liver disease
  • History of liver disease
  • Taking alcohol or other drugs that can damage the liver.
  • Infected with hepatitis B.
  • Not taking Atripla (Efavirenz / Emtricitabine / Tenofovir) regularly
  • History of seizures.
      • Starting Atripla (Efavirenz / Emtricitabine / Tenofovir) in the first two weeks.
        • Kidney damage
        Detailed Atripla (Efavirenz / Emtricitabine / Tenofovir) risks & warnings »
        • Women
        • Obesity
        • Liver disease
          • Kidney damage
          • Prior bone fractures
          • Osteoporosis
          • HIV
          • Exposure to other infections
          • Start of a new HIV medication
          • Change in HIV therapy
          • HIV treatment
          Detailed Viread (Tenofovir) risks & warnings »
          Pregnancy category
          AtriplaViread
          DFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          • Atripla (Efavirenz / Emtricitabine / Tenofovir) can damage your liver and is not recommended if you have severe liver disease. Try to limit or avoid alcohol to reduce this risk. Call your doctor right away if you start to have clay-colored stools, yellowing of the eyes or skin, dark urine, stomach pain, or if you are eating less than usual without trying to.
          No specific alcohol-related info.
          Food
          No specific food-related info.
          • The tenofovir powder can't be mixed in a liquid, so mix into soft food like applesauce and yogurt.
          • Take tenofovir once a day, with or without food.
          Kidneys and liver
          • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause kidney damage, increase your risk of depression, and shouldn't be taken if you have a history of seizures or osteoporosis.
          • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Atripla (Efavirenz / Emtricitabine / Tenofovir). It may not be a good choice for people with liver problems.
          • Atripla (Efavirenz / Emtricitabine / Tenofovir) is removed from the body by the kidney. Kidney (renal) damage, including cases of renal failure and Fanconi syndrome (injury to the tubes inside of the kidney), has been reported with the use of Atripla (Efavirenz / Emtricitabine / Tenofovir). Your doctor must continually monitor the function of your kidneys while you are taking Atripla (Efavirenz / Emtricitabine / Tenofovir).
          • The dose of tenofovir depends on how your kidneys work. It is really important to consistently monitor them with your doctor.
          • Don't take other drugs that can hurt your kidneys while taking tenofovir without talking to your doctor. That sadly includes non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin, Advil, and Aleve.
          • Work with your doctor to monitor your kidney function and bone mineral density regularly.
          • tenofovir can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use tenofovir. It may not be a good choice for people with liver problems.
          • tenofovir is removed from the body by the kidney. Kidney (renal) damage, including cases of renal failure and Fanconi syndrome (injury to the tubes inside of the kidney), has been reported with the use of tenofovir. Your doctor must continually monitor the function of your kidneys while you are taking tenofovir.
          Sex
          • Practice safe sex since Atripla (Efavirenz / Emtricitabine / Tenofovir) won't cure HIV or prevent it from being passed on to other people.
          No specific sex-related info.
          Sleep
          • Can cause stomach upset, headache, nausea, difficulty sleeping, vivid dreams, or depression.
          • You can experience some central nervous system side effects when starting Atripla (Efavirenz / Emtricitabine / Tenofovir), such as dizziness, trouble sleeping, difficulty concentrating, drowsiness, and strange dreams. Taking Atripla (Efavirenz / Emtricitabine / Tenofovir) at bedtime will help lower the risk of experiencing these side effects. If these symptoms don't go away and it bothers you, let your doctor know.
          No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          AtriplaViread
          • Atripla (Efavirenz / Emtricitabine / Tenofovir) is very effective at treating HIV infection.
          • Contains three medications in one tablet, so it’s convenient to take.
          • Generally well-tolerated (not as many side effects) compared to other HIV drugs.
          • Take tenofovir once a day, with or without food.
          • For people who can't swallow the tablet, take the powder instead.
          • tenofovir is used for HIV in kids 2 years and older, and chronic hepatitis B in kids 12 years and older.
          Downsides and risks
          AtriplaViread
          • Important to take at the same time every day to make sure the virus doesn’t become resistant to the medication.
          • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause kidney damage, increase your risk of depression, and shouldn't be taken if you have a history of seizures or osteoporosis.
          • Women should avoid becoming pregnant while taking Atripla (Efavirenz / Emtricitabine / Tenofovir) and for 12 weeks after stopping Atripla (Efavirenz / Emtricitabine / Tenofovir).
          • The tenofovir powder can't be mixed in a liquid, so mix into soft food like applesauce and yogurt.
          • The dose of tenofovir depends on how your kidneys work. It is really important to consistently monitor them with your doctor.
          Tips from our pharmacists for people taking the medication
          AtriplaViread
          • Take at bedtime on an empty stomach to lower possible side effects.
          • Take at the same time every day.
          • Can cause stomach upset, headache, nausea, difficulty sleeping, vivid dreams, or depression.
          • Let your doctor know if you start to get a rash.
          • Practice safe sex since Atripla (Efavirenz / Emtricitabine / Tenofovir) won't cure HIV or prevent it from being passed on to other people.
          • Don't take other drugs that can hurt your kidneys while taking tenofovir without talking to your doctor. That sadly includes non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin, Advil, and Aleve.
          • People with HIV should be tested for Hepatitis B virus (HBV) before starting tenofovir.
          • Similarly, patients with chronic hepatitis B, should be tested for HIV before starting tenofovir.
          • Decreases in bone mineral density can happen while taking tenofovir.
          • Work with your doctor to monitor your kidney function and bone mineral density regularly.
          Learn more
          More about AtriplaSide effectsReviews & ratingsAlternativesFDA package insert
          More about VireadSide effectsAlternativesFDA package insert