Compare Atripla vs. Viread

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Atripla
(efavirenz / emtricitabine / tenofovir)

Viread
(tenofovir)

Treats HIV infection. Atripla (efavirenz / emtricitabine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It is a second-line choice due to its high incidence of undesired side effects.Works with other medicines to treat HIV infection. Also treats Hepatitis B Virus. Viread (tenofovir) is a first-line choice to be used in combination with other medications to treat HIV. Viread (tenofovir) is also a first-line choice in treating HBV.
Reviews & ratings
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Have you used Atripla (efavirenz / emtricitabine / tenofovir)?
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Have you used Viread (tenofovir)?
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Side effects
AtriplaViread
  • Diarrhea 9%
  • Depression 9%
  • Fatigue 9%
  • Nausea 9%
  • Sinusitis 8%
  • Upper respiratory tract infections 8%
  • Dizziness 8%
  • Rash Event 7%
  • Headache 6%
  • Anxiety 5%
More Atripla side effects »
  • Rash 18%
  • Diarrhea 5%
  • Headache 14%
  • Pain 13%
  • Depression 11%
  • Nausea 4%
  • Weakness 10%
  • Back pain 9%
  • Abdominal pain 22%
  • Insomnia 18%
More Viread side effects »
How it works
AtriplaViread
Atripla (efavirenz / emtricitabine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.Viread (tenofovir) is a nucleoside reverse transcriptase inhibitor that prevents both HIV and hepatitis B virus from making copies of itself.
Type of medication
AtriplaViread
Prescription only
Available as
AtriplaViread
  • Pill
  • Pill
  • Powder
Used for
AtriplaViread
Risk factors for serious side effects
AtriplaViread
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental health problems
Detailed Atripla (efavirenz / emtricitabine / tenofovir) risks & warnings »
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental illness
Detailed Viread (tenofovir) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
AtriplaViread
No food related info.
  • Taken only once daily, with or without food.
Kidneys and liver
AtriplaViread
  • One of the medications in Atripla (efavirenz / emtricitabine / tenofovir) can cause kidney damage. This can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles.
  • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
  • Viread (tenofovir) is not yet approved for treating Hepatitis B. If you have hepatitis B and HIV, don't stop taking Viread (tenofovir) without talking to your doctor since your hepatitis can get worse. Your doctor will check your liver regularly.
  • People on Viread (tenofovir) have reported kidney damage, which can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain and weakness in your muscles.
  • There are newer formulations of Viread (tenofovir) available that are safer on your kidneys.
  • Not recommended for patients with kidney damage.
Upsides and benefits
AtriplaViread
  • Atripla (efavirenz / emtricitabine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Atripla (efavirenz / emtricitabine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
  • Can be used with other medications to prevent HIV infection after an exposure.
  • Taken only once daily, with or without food.
  • There are newer formulations of Viread (tenofovir) available that are safer on your kidneys.
  • If tablets are hard for you to swallow, Viread (tenofovir) is available in a powder that's mixed with soft foods.
Downsides and risks
AtriplaViread
  • Atripla (efavirenz / emtricitabine / tenofovir) can increase your risk of depression, and should be used with caution you have a history of seizures or osteoporosis.
  • Women should avoid becoming pregnant while taking Atripla (efavirenz / emtricitabine / tenofovir) and for 12 weeks after stopping Atripla (efavirenz / emtricitabine / tenofovir).
  • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
  • Viread (tenofovir) can't be used on its own to treat HIV infection.
  • Not recommended for patients with kidney damage.
  • Can weaken your bones.
  • Might worsen hepatitis B infections if you suddenly stop taking it.
Tips from our pharmacists for people taking the medication
AtriplaViread
  • Side effects such as dizziness, insomnia, and/or abnormal dreams are common within the first few weeks of starting Atripla (efavirenz / emtricitabine / tenofovir). Talk to your doctor if these side effects last longer or are preventing you from taking your medication regularly.
  • Should be taken on an empty stomach at bedtime to reduce side effects.
  • Women taking Atripla (efavirenz / emtricitabine / tenofovir) should be on effective form(s) of contraception, as Atripla (efavirenz / emtricitabine / tenofovir) can cause birth defects.
  • Keep your regularly scheduled doctor's and lab appointments. These help ensure your medication is working well and safely.
  • Avoid taking NSAIDs (non-steroidal anti-inflammatory drugs) like aspirin, ibuprofen, and Aleve in order to prevent damage to kidneys.
  • Patients should be tested for both HIV and Hepatitis B virus (HBV) before starting Viread (tenofovir).
  • Viread (tenofovir) powder should be mixed into soft food like applesauce or yogurt. Take it immediatly after mixing, otherwise the taste can turn bitter. Viread (tenofovir) powder cannot be mixed into liquids.
  • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your prescriber.
  • Keep your regularly scheduled doctor's and lab appointments. These help ensure your medication is working well and safely.
Learn more
More about AtriplaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Atripla (efavirenz / emtricitabine / tenofovir)?
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More about VireadSide effectsAlternativesFDA package insert
Have you used Viread (tenofovir)?
Worth itNot sureNot worth it