Compare Atripla vs. Viread

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Atripla
(efavirenz / emtricitabine / tenofovir)

Viread
(tenofovir)

Treats HIV infection. Atripla (efavirenz / emtricitabine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It is a second-line choice due to its high incidence of undesired side effects.Works with other medicines to treat HIV infection. Also treats Hepatitis B Virus. tenofovir can be a good choice to take within the Nucleoside Reverse Transcriptase Inhibitor (NRTI) drug class. It may not be the best choice though for people with kidney problems.
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Prices and coupon for 30 (600mg/200mg/300mg) tablets of efavirenz / emtricitabine / tenofovir
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Prices and coupon for 30 (300mg) tablets of tenofovir
Reviews & ratings
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Have you used Atripla (efavirenz / emtricitabine / tenofovir)?
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Have you used Viread (tenofovir)?
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Side effects
AtriplaViread
  • Diarrhea 9%
  • Low mood disorder 9%
  • Fatigue 9%
  • Nausea 9%
  • Sinus inflammation 8%
  • Ear, nose, or throat infection 8%
  • Dizziness 8%
  • Rash event 7%
  • Headache 6%
  • Anxiety 5%
More Atripla side effects »

We haven’t found good data for Viread side effects.

FDA side effect reports for Viread »
How it works
AtriplaViread
Atripla (efavirenz / emtricitabine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.tenofovir stops the replication of the human immunodeficiency virus (HIV) within important cells of the body by preventing the virus from taking over normal functions of the cell for its own purposes.
Type of medication
AtriplaViread
Prescription only
Available as
AtriplaViread
  • Pill
  • Pill
  • Liquid
Used for
AtriplaViread
  • HIV Infection
Risk factors for serious side effects
AtriplaViread
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental health problems
  • History of drug abuse
  • History of liver disease
  • Taking alcohol or other drugs that can damage the liver.
  • History of bone fractures
  • Osteoporosis
  • History of kidney damage
  • Taking other medicines that can harm the kidneys
Detailed Atripla (efavirenz / emtricitabine / tenofovir) risks & warnings »
  • Women
  • Obesity
  • Liver disease
    • Kidney damage
    • Prior bone fractures
    • Osteoporosis
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
    • HIV treatment
    Detailed Viread (tenofovir) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Kidneys and liver
    AtriplaViread
    • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
    • One of the medications in Atripla (efavirenz / emtricitabine / tenofovir) can cause kidney damage. This can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles.
    • The dose of tenofovir depends on how your kidneys work. It is really important to consistently monitor them with your doctor.
    • Don't take other drugs that can hurt your kidneys while taking tenofovir without talking to your doctor. That sadly includes non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin, Advil, and Aleve.
    • tenofovir can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use tenofovir. It may not be a good choice for people with liver problems.
    • Severe worsening of Hepatitis B has been seen in patients who have stopped taking tenofovir. Liver function should be closely watched in people who have both HIV and HBV.
    • tenofovir is removed from the body by the kidney. Kidney (renal) damage, including cases of renal failure and Fanconi syndrome (injury to the tubes inside of the kidney), has been reported with the use of tenofovir. Your doctor must continually monitor the function of your kidneys while you are taking tenofovir.
    Upsides and benefits
    AtriplaViread
    • Atripla (efavirenz / emtricitabine / tenofovir) combines three medications into one tablet, so it's easy to take.
    • Atripla (efavirenz / emtricitabine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
    • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
    • Take tenofovir once a day, with or without food.
    • For people who can't swallow the tablet, take the powder instead.
    • tenofovir is used for HIV in kids 2 years and older, and chronic hepatitis B in kids 12 years and older.
    Downsides and risks
    AtriplaViread
    • Atripla (efavirenz / emtricitabine / tenofovir) can increase your risk of depression, and should be used with caution you have a history of seizures or osteoporosis.
    • Women should avoid becoming pregnant while taking Atripla (efavirenz / emtricitabine / tenofovir) and for 12 weeks after stopping Atripla (efavirenz / emtricitabine / tenofovir).
    • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
    • The tenofovir powder can't be mixed in a liquid, so mix into soft food like applesauce and yogurt.
    • The dose of tenofovir depends on how your kidneys work. It is really important to consistently monitor them with your doctor.
    Tips from our pharmacists for people taking the medication
    AtriplaViread
    • Side effects such as dizziness, insomnia, and/or abnormal dreams are common within the first few weeks of starting Atripla (efavirenz / emtricitabine / tenofovir). Talk to your doctor if these side effects last longer or are preventing you from taking your medication regularly.
    • Should be taken on an empty stomach at bedtime to reduce side effects.
    • Women taking Atripla (efavirenz / emtricitabine / tenofovir) should be on effective form(s) of contraception, as Atripla (efavirenz / emtricitabine / tenofovir) can cause birth defects.
    • Keep your regularly scheduled doctor's and lab appointments. These help ensure your medication is working well and safely.
    • Don't take other drugs that can hurt your kidneys while taking tenofovir without talking to your doctor. That sadly includes non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin, Advil, and Aleve.
    • People with HIV should be tested for Hepatitis B virus (HBV) before starting tenofovir.
    • Similarly, patients with chronic hepatitis B, should be tested for HIV before starting tenofovir.
    • Decreases in bone mineral density can happen while taking tenofovir.
    • Work with your doctor to monitor your kidney function and bone mineral density regularly.
    Learn more
    More about AtriplaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Atripla (efavirenz / emtricitabine / tenofovir)?
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    More about VireadSide effectsAlternativesFDA package insert
    Have you used Viread (tenofovir)?
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