Compare Aubagio vs. Copaxone

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Treats relapsing forms of MS. Aubagio (Teriflunomide) is an oral medicine that effectively reduces the number of flare-ups, slows physical changes, and decreases the number of new brain lesions in relapsing MS. Because it stays in the body for so long, if you have a serious reaction or possible pregnancy you'll need to have it quickly removed with another medicine.Lowers the frequency of multiple sclerosis exacerbations. Copaxone (Glatiramer) is an injectable medicine that's effective for relapsing, remitting MS. It has fewer side effects than other meds, but the self-injections are needed frequently.
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Have you used Aubagio (Teriflunomide)?
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Side effects
  • Hair loss or baldness 10%
  • Diarrhea 9%
  • Mild hypophospatemia 9%
  • Alanine aminotransferase increased 7%
  • Nausea 7%
  • Headache 4%
  • Moderate hypophospatemia 4%
  • Gamma-glutamyltransferase increase 4%
  • Gastroenteritis viral 3%
  • Bladder infection 3%
More Aubagio side effects »
  • Injection site erythema 33%
  • Infection 27%
  • Injection site pruritus 23%
  • Injection site pain 20%
  • Injection site mass 20%
  • Widening of blood vessels 15%
  • Injection site edema 15%
  • Nausea 14%
  • Shortness of breath 10%
  • Injection site inflammation 8%
More Copaxone side effects »
How it works
Aubagio (Teriflunomide) is an immune modulator. Researchers don't know exactly how it works for MS, but it seems to lower your white blood cells and keep them from attacking the nerves in your brain and spinal cord.Copaxone (Glatiramer) is an immune modulator that alters the immune process. Researchers don't know exactly how it works. It's thought to "trick" out-of-control immune cells and slow their attacks on nerves.
Type of medication
Multiple Sclerosis treatment
Pyrimidine synthesis inhibitor
Prescription only
Multiple sclerosis treatment
Prescription only
Available as
  • Pill
  • Injection
Used for (click to learn more)
Risk factors for serious side effects
  • Taking medicines that affect your liver or cause liver injury
      • Reaction to leflunomide
      • Age 60 or older
      • Taking medicines that are toxic to the nervous system
      • Diabetes
      • Taking other immunosuppressant drugs
      • Age 60 or older
      • Weak immune system
      • High uric acid levels
        • Acute kidney failure
        • History of lung disease
        • History of high blood pressure
        Detailed Aubagio (Teriflunomide) risks & warnings »
                  Detailed Copaxone (Glatiramer) risks & warnings »
                  Pregnancy category
                  XFDA pregnancy category (Unsafe)

                  Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

                  See the FDA package insert
                  BFDA pregnancy category (Probably safe)

                  Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                  See the FDA package insert
                  • It comes a 7 mg and 14mg dose and only needs to be taken once a day, with or without food.
                  • Take one capsule daily with or without food.
                  No specific food related info.
                  Kidneys and liver
                  • Aubagio can also cause serious and life-threatening liver, lung, skin, kidney and blood pressure effects.
                  • People taking Aubagio (Teriflunomide) had temporary acute kidney failure thought to be due to high uric acid buildup in the kidneys (uric acid nephropathy). Kidney function started to decrease from 12 weeks to 2 years after the first dose, then returned to normal with continued dosing. It’s not completely clear is there were other reasons for this effect and people generally didn't have any symptoms.
                  • Aubagio (Teriflunomide) has caused high blood potassium levels in people that also had acute kidney failure. Your doctor will do tests to check your potassium levels especially if you already have kidney problems.
                  No specific kidneys and liver related info.
                  Upsides and benefits
                  • You can take it by mouth.
                  • It comes a 7 mg and 14mg dose and only needs to be taken once a day, with or without food.
                  • In clinical studies, Aubagio reduced relapses, slowed disability, and decreased the number of new brain lesions compared to sugar pill (placebo).
                  • Although it may not work for everyone, most people felt it wasn't much of a hassle.
                  • One of the main treatments for relapsing multiple sclerosis (MS) that has been around for many years.
                  • Helps reduce the frequency of MS relapse episodes.
                  • Fewer side effects than other injectable MS medicines, like interferons.
                  • Can be helpful in maintaining nerve functions.
                  • Likely safe to use during pregnancy.
                  • Copaxone (Glatiramer) is a possible treatment for primary-progressive MS (PPMS) even though the clinical evidence is not conclusive (there are currently no approved treatments for PPMS).
                  Downsides and risks
                  • Some people have nausea and diarrhea when they start treatment. In most cases, these effects are mild and get better over time.
                  • Aubagio can cause your hair to thin. This is temporary, and your hair will go back to normal after a few months.
                  • You should have certain lab tests to make sure you don't have any problems from taking Aubagio. These include: complete blood count and liver enzyme testing within 6 months before you start treatment, tuberculosis (TB) screening, and blood pressure.
                  • Numbness or tingling in your hands and feet (peripheral neuropathy), different from MS was reported more often than with sugar pill (placebo)
                  • Aubagio may stay in your blood up to 2 years after you stop taking it. You can quickly remove Aubagio the accelerated elimination procedure, but symptoms of your disease may return.
                  • You can't take it if you're pregnant.
                  • Requires injections, either day or every other day (but no more than three times a week), depending on the dose you're taking.
                  • Injection site reactions are common with pain, redness, swelling, and lipoatrophy (loss of fat under the skin where the injection is made).
                  • Doesn't stop the progression of MS.
                  Tips from our pharmacists for people taking the medication
                  • Take one capsule daily with or without food.
                  • It's very important you read the Aubagio Medication Guide.
                  • Most common side effects are diarrhea, nausea, hair thinning, and elevated liver blood levels.
                  • Not the best choice if you have liver problems or are on medications that affect the liver.
                  • Liver blood tests need to be done for 6 months once you start taking Aubagio. If these tests are abnormal and liver damage is suspected your doctor will stop the medicine and tell you to start taking cholestyramine for 11 days to lower the toxic level.
                  • You'll need to have a TB test before you start taking Aubagio.
                  • Can cause numbness and tingling of your hands and feet. Let your doctor know if this becomes a problem.
                  • Aubagio increases your risk of infections so tell your doctor if you notice a fever, cough that doesn't go away, or flu-like symptoms. Get your blood counts checked 6 months before starting treatment.
                  • Aubagio can also cause serious and life-threatening liver, lung, skin, kidney and blood pressure effects.
                  • Aubagio will harm your unborn baby and is pregnancy category X. You must have a negative pregnancy test before starting Aubagio.
                  • Both men and women are affected. If they want to have a baby both need to stop taking Aubagio and begin rapid removal process using cholestyramine or activated charcoal for 11 days. Without this process, Aubagio will stay in the body for up to 2 years.
                  • Inject yourself at the same time every day into your subcutaneous fat (the layer between your skin and muscle).
                  • Injection site reactions are common. Symptoms include swelling, redness, and pain.
                  • Rarely, can cause a fast and irregular heartbeat, shortness of breath, or flushing that usually goes away after 10-15 minutes.
                  • You can keep syringes at room temperature for up to a month if you can't store them in the refrigerator.
                  Learn more
                  More about AubagioSide effectsReviews & ratingsAlternativesFDA package insert
                  Have you used Aubagio (Teriflunomide)?
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                  More about CopaxoneSide effectsReviews & ratingsAlternativesFDA package insert
                  Have you used Copaxone (Glatiramer)?
                  Worth itNot sureNot worth it