Compare Augmentin vs. Amoxicillin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Augmentin
(Amoxicillin / Clavulanate)

Amoxil
(Amoxicillin)

Kills bacteria. Augmentin (Amoxicillin / Clavulanate) is good for treating many bacterial infections and is available as generic. However, it will make birth control pills less effective. It also has to be taken with food since it can cause an upset stomach.Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.28Augmentin
Reviews for Augmentin (Amoxicillin / Clavulanate)
68%
of people (All ages) say Augmentin (Amoxicillin / Clavulanate) is worth it
52%
say it works well
13%
say it's a big hassle
1034 reviews
Have you used Augmentin (Amoxicillin / Clavulanate)?
Worth itNot sureNot worth it
Reviews for Amoxil (Amoxicillin)
62%
-6% worse vs. Augmentin (Amoxicillin / Clavulanate)
45%
-7% worse vs. Augmentin (Amoxicillin / Clavulanate)
14%
-1% worse vs. Augmentin (Amoxicillin / Clavulanate)
786 reviews
Have you used Amoxil (Amoxicillin)?
Worth itNot sureNot worth it
Side effects
AugmentinAmoxicillin
  • Diarrhea 9%
  • Nausea 3%
  • Skin rashes and urticaria 3%
More Augmentin side effects »
  • Any side effect 11%
  • Vulvovaginal mycotic infection 2%
  • Diarrhea 2%
More Amoxicillin side effects »
How it works
AugmentinAmoxicillin
Augmentin (Amoxicillin / Clavulanate) is a combination antibiotic. Amoxicillin kills bacteria and prevents them from reproducing and making their own protective covering. Clavulanate stops chemicals the bacteria make to resist antibiotics.Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.
Type of medication
AugmentinAmoxicillin
Prescription only
Prescription only
Available as
AugmentinAmoxicillin
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
Used for
AugmentinAmoxicillin
Risk factors for serious side effects
AugmentinAmoxicillin
  • Mononucleosis
    • History of liver disease
      Detailed Augmentin (Amoxicillin / Clavulanate) risks & warnings »
      • Long antibiotic treatment period
      • History of penicillin allergies
      • Using oral birth control pills
        Detailed Amoxil (Amoxicillin) risks & warnings »
        Pregnancy

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Food
        AugmentinAmoxicillin
        • Should be taken with food since it can cause stomach upset.
        • Take each dose with a meal since it may cause an upset stomach.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        Kidneys and liver
        AugmentinAmoxicillin
        • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
        No kidneys and liver related info.
        Upsides and benefits
        AugmentinAmoxicillin
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        Downsides and risks
        AugmentinAmoxicillin
        • If you're on birth control pills, you should use a barrier method (condoms, diaphragms) since Augmentin can make them less effective.
        • Should be taken with food since it can cause stomach upset.
        • If you have phenylketonuria (PKU), talk to your doctor to prescribe an alternative.
        • Suspension must be stored in the fridge.
        • Can make birth control pills and live vaccines less effective.
        • Many bacteria have developed resistance to this antibiotic.
        • Can cause diarrhea.
        Tips from our pharmacists for people taking the medication
        AugmentinAmoxicillin
        • Take this medication exactly as your doctor tells you to.
        • Take each dose with a meal since it may cause an upset stomach.
        • If you are taking birth control pills, this can make it less effective.
        • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
        • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
        • If you're taking birth control pills, this medication may make them less effective.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
        • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
        • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
        Learn more
        More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Augmentin (Amoxicillin / Clavulanate)?
        Worth itNot sureNot worth it
        More about AmoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Amoxil (Amoxicillin)?
        Worth itNot sureNot worth it