Compare Augmentin vs. Amoxicillin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Augmentin
(Amoxicillin / Clavulanate)

Amoxil
(Amoxicillin)

Kills bacteria. Augmentin (Amoxicillin / Clavulanate) is good for treating many bacterial infections and is available as generic. However, it will make birth control pills less effective. It also has to be taken with food since it can cause an upset stomach.Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.293137254901961Augmentin
Reviews for Augmentin (Amoxicillin / Clavulanate)
68%
of people say Augmentin (Amoxicillin / Clavulanate) is worth it
52%
say it works well
13%
say it's a big hassle
Reviews for Amoxil (Amoxicillin)
62%
6% vs. Augmentin (Amoxicillin / Clavulanate)
45%
7% vs. Augmentin (Amoxicillin / Clavulanate)
14%
1% vs. Augmentin (Amoxicillin / Clavulanate)
Side effects
AugmentinAmoxicillin

The Augmentin FDA package insert doesn’t have numbers about how common side effects are.

More about Augmentin side effects »

The Amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Amoxicillin side effects »
How it works
AugmentinAmoxicillin
Augmentin (Amoxicillin / Clavulanate) is a combination antibiotic. Amoxicillin kills bacteria and prevents them from reproducing and making their own protective covering. Clavulanate stops chemicals the bacteria make to resist antibiotics.Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.
Type of medication
AugmentinAmoxicillin
Antibiotic
Penicillin
Prescription only
Antibiotic
Penicillin
Prescription only
Available as
AugmentinAmoxicillin
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
AugmentinAmoxicillin
Risk factors for serious side effects
AugmentinAmoxicillin
  • Mononucleosis
    • History of liver disease
      Detailed Augmentin (Amoxicillin / Clavulanate) risks & warnings »
      • Long antibiotic treatment period
      • History of penicillin allergies
      • Using oral birth control pills
        Detailed Amoxil (Amoxicillin) risks & warnings »
        Pregnancy category
        AugmentinAmoxicillin
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Should be taken with food since it can cause stomach upset.
        • Take each dose with a meal since it may cause an upset stomach.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        AugmentinAmoxicillin
        • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        Downsides and risks
        AugmentinAmoxicillin
        • If you're on birth control pills, you should use a barrier method (condoms, diaphragms) since Augmentin can make them less effective.
        • Should be taken with food since it can cause stomach upset.
        • If you have phenylketonuria (PKU), talk to your doctor to prescribe an alternative.
        • Suspension must be stored in the fridge.
        • Can make birth control pills and live vaccines less effective.
        • Many bacteria have developed resistance to this antibiotic.
        • Can cause diarrhea.
        Tips from our pharmacists for people taking the medication
        AugmentinAmoxicillin
        • Take this medication exactly as your doctor tells you to.
        • Take each dose with a meal since it may cause an upset stomach.
        • If you are taking birth control pills, this can make it less effective.
        • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
        • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
        • If you're taking birth control pills, this medication may make them less effective.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
        • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
        • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
        Learn more
        More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
        More about AmoxicillinSide effectsReviews & ratingsAlternativesFDA package insert