Compare Augmentin vs. Azithromycin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Augmentin
(Amoxicillin / Clavulanate)

Zithromax
(Azithromycin)

Kills bacteria. Augmentin (Amoxicillin / Clavulanate) is good for treating many bacterial infections and is available as generic. However, it will make birth control pills less effective. It also has to be taken with food since it can cause an upset stomach.Kills bacteria. Zithromax (Azithromycin) is good for treating many bacterial infections. It is also available as generic. Talk to your doctor if you've ever had liver disease, myasthenia gravis, or on medications to thin the blood, as the doctor may write an alternative.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.293137254901961Augmentin
Reviews for Augmentin (Amoxicillin / Clavulanate)
68%
of people say Augmentin (Amoxicillin / Clavulanate) is worth it
52%
say it works well
13%
say it's a big hassle
Reviews for Zithromax (Azithromycin)
74%
+6% vs. Augmentin (Amoxicillin / Clavulanate)
59%
+7% vs. Augmentin (Amoxicillin / Clavulanate)
11%
+2% vs. Augmentin (Amoxicillin / Clavulanate)
Side effects
AugmentinAzithromycin

The Augmentin FDA package insert doesn’t have numbers about how common side effects are.

More about Augmentin side effects »

The Azithromycin FDA package insert doesn’t have numbers about how common side effects are.

More about Azithromycin side effects »
How it works
AugmentinAzithromycin
Augmentin (Amoxicillin / Clavulanate) is a combination antibiotic. Amoxicillin kills bacteria and prevents them from reproducing and making their own protective covering. Clavulanate stops chemicals the bacteria make to resist antibiotics.Zithromax (Azithromycin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
AugmentinAzithromycin
Antibiotic
Penicillin
Prescription only
Antibiotic
Macrolide
Prescription only
Available as
AugmentinAzithromycin
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Liquid
  • Eye drops
Used for (click to learn more)
AugmentinAzithromycin
Risk factors for serious side effects
AugmentinAzithromycin
  • Mononucleosis
    • History of liver disease
      Detailed Augmentin (Amoxicillin / Clavulanate) risks & warnings »
          • History of liver disease
          • History of myasthenia gravis
          Detailed Zithromax (Azithromycin) risks & warnings »
          Pregnancy category
          AugmentinAzithromycin
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Should be taken with food since it can cause stomach upset.
          • Take each dose with a meal since it may cause an upset stomach.
          • Can be taken with or without food.
          • Can take with or without food.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          AugmentinAzithromycin
          • Available in generic.
          • Available in different forms: tablet, capsule, and suspension.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Can be taken with or without food.
          • Available in generic.
          • Available in different forms: tablet, capsule, and suspension.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          Downsides and risks
          AugmentinAzithromycin
          • If you're on birth control pills, you should use a barrier method (condoms, diaphragms) since Augmentin can make them less effective.
          • Should be taken with food since it can cause stomach upset.
          • If you have phenylketonuria (PKU), talk to your doctor to prescribe an alternative.
          • Must space out antacids by at least 2 hours.
          • Has to be used with caution in people who've had liver disease.
          • Can't be used in people who've had myasthenia gravis.
          • Must be used with caution in people who are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
          • Can cause abdominal pain, diarrhea, vomiting, and nausea.
          Tips from our pharmacists for people taking the medication
          AugmentinAzithromycin
          • Take this medication exactly as your doctor tells you to.
          • Take each dose with a meal since it may cause an upset stomach.
          • If you are taking birth control pills, this can make it less effective.
          • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
          • Take the medication exactly how your doctor tells you to.
          • Can cause diarrhea, nausea or vomiting.
          • Space out any antacids with magnesium or aluminum by at least 2 hours.
          • Can take with or without food.
          Learn more
          More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
          More about AzithromycinSide effectsReviews & ratingsAlternativesFDA package insert