Compare Augmentin vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(amoxicillin / clavulanate)

(sulfamethoxazole / trimethoprim)

Treats bacterial infections. Augmentin (amoxicillin / clavulanate) is first-choice antibiotic for most common types of infections. However, it may not work against more serious or uncommon types of infections.Kills bacteria. Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Augmentin
of people (All ages) say Augmentin is worth it
say it works well
say it's a big hassle
1034 reviews
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it
Reviews for Bactrim
+9% better vs. Augmentin
+3% better vs. Augmentin
+9% better vs. Augmentin
473 reviews
Have you used Bactrim (sulfamethoxazole / trimethoprim)?
Worth itNot sureNot worth it
Side effects
  • Diarrhea 9%
  • Nausea 3%
  • Skin rash and hives 3%
More Augmentin side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
How it works
Augmentin (amoxicillin / clavulanate) contains two antibiotic medicines, which kill bacteria.Bactrim (sulfamethoxazole / trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria.
Type of medication
Prescription onlyPrescription only
Available as
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Liquid
Used for
Risk factors for serious side effects
  • History of penicillin allergies
  • Taking Augmentin (amoxicillin / clavulanate) for a long time
  • Mononucleosis
  • Using oral birth control pills
Detailed Augmentin (amoxicillin / clavulanate) risks & warnings »
  • Elderly
  • Taking other medicines that lower kidney function
Detailed Bactrim (sulfamethoxazole / trimethoprim) risks & warnings »

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

  • Take with food if you're having upset stomach.
No food related info.
Kidneys and liver
  • Liver damage has been associated with patients taking Augmentin (amoxicillin / clavulanate). It's usually reversible, but deaths have been reported. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
  • Bactrim (sulfamethoxazole / trimethoprim) can harm your kidneys, especially if you're taking anti-inflammatory pain relievers like Motrin or Advil or other medicines that also affect your kidneys. Make sure to drink plenty of water or fluids while you're taking Bactrim (sulfamethoxazole / trimethoprim).
Upsides and benefits
  • Available as generic product.
  • Available in tablet, capsule, and liquid forms.
  • Used to treat most common types of bacterial infections.
  • Side effects are generally not too bad compared to other antibiotics.
  • Widely available as a generic product and in a variety of formulations (tablet, capsule, suspension).
  • Works well to treat many types of bacterial infections
Downsides and risks
  • Many bacteria have developed resistance to this antibiotic.
  • Can cause diarrhea, nausea, and vomiting.
  • Birth control pills may not work as well to prevent pregnancy when taking this medication.
  • Makes you sensitive to the sun.
  • Can upset your stomach
  • Drink plenty of water or fluids to avoid harming your kidneys
  • May cause birth defects
Tips from our pharmacists for people taking the medication
  • Finish all of your medicine even if you start to feel better. Stopping it early can cause the infection to come back stronger than before.
  • Can make your oral birth control less effective. Consult your doctor or pharmacist if you need to use backup.
  • Take with food if you're having upset stomach.
  • Store the liquid in the fridge and throw away after 10 days.
  • Shake the suspension thoroughly before using each dose.
  • Take Bactrim (sulfamethoxazole / trimethoprim) exactly the way your doctor tells you.
  • Can make you more sensitive to the sun. Keep out of the sun or wear protection while under the sun.
  • Drink plenty of water or liquids while on Bactrim (sulfamethoxazole / trimethoprim) to avoid harming your kidneys.
  • Can cause upset stomach.
  • Can cause an allergic reaction. Talk to your doctor if you notice skin rash or swelling of your face.
Learn more
More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it
More about BactrimSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Bactrim (sulfamethoxazole / trimethoprim)?
Worth itNot sureNot worth it