Compare Augmentin vs. Cipro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(amoxicillin / clavulanate)


Treats bacterial infections. Augmentin (amoxicillin / clavulanate) is first-choice antibiotic for most common types of infections. However, it may not work against more serious or uncommon types of infections.Kills bacteria. Cipro (Ciprofloxacin) is a good and cheap antibiotic to treat many types of bacterial infections. However, you have to reduce your caffeine intake, and have to protect yourself from the sun.
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Coupons for Cipro
Best available price for 20 (500mg) tablets of ciprofloxacin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Augmentin (amoxicillin / clavulanate)
of people (All ages) say Augmentin (amoxicillin / clavulanate) is worth it
say it works well
say it's a big hassle
1034 reviews
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it
Reviews for Cipro (ciprofloxacin)
-5% worse vs. Augmentin (amoxicillin / clavulanate)
+1% better vs. Augmentin (amoxicillin / clavulanate)
-4% worse vs. Augmentin (amoxicillin / clavulanate)
755 reviews
Have you used Cipro (ciprofloxacin)?
Worth itNot sureNot worth it
Side effects
  • Diarrhea 9%
  • Nausea 3%
  • Skin rash and hives 3%
More Augmentin side effects »
  • Any musculosketal side effect 14%
  • Any side effect 41%
  • Any musculoskeletal side effect 9%
  • Any neurological side effect 3%
  • Nausea 3%
  • Diarrhea 2%
  • Any gastrointestinal side effect 15%
  • Any serious side effect 8%
  • Vomiting 5%
  • Abdominal pain 3%
More Cipro side effects »
How it works
Augmentin (amoxicillin / clavulanate) contains two antibiotic medicines, which kill bacteria.Cipro (Ciprofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
Prescription only
Prescription only
Available as
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Extended release
  • Infusion (iv)
Used for
Risk factors for serious side effects
  • History of penicillin allergies
  • Taking Augmentin (amoxicillin / clavulanate) for a long time
  • Mononucleosis
  • Using oral birth control pills
Detailed Augmentin (amoxicillin / clavulanate) risks & warnings »
  • Over 60 years of age
  • On long-term steroid use
  • Heart, kidney, or lung transplant
  • Myasthenia gravis
Detailed Cipro (ciprofloxacin) risks & warnings »

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

  • Take with food if you're having upset stomach.
No food related info.
Kidneys and liver
  • Liver damage has been associated with patients taking Augmentin (amoxicillin / clavulanate). It's usually reversible, but deaths have been reported. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
No kidneys and liver related info.
No pain related info.
  • If you notice pain in your Achilles tendons, contact your doctor.
  • If you notice redness/inflammation, pain or swelling in your joints or muscles, especially in the Achilles tendon, contact your doctor immediately.
  • Talk to your doctor immediately if you start to feel burning, tingling, numbness, pain or you can't tolerate heat or cold. This could be a sign of nerve damage and it can happen as soon as you start taking the medication and may not go away if you stop it.
Upsides and benefits
  • Available as generic product.
  • Available in tablet, capsule, and liquid forms.
  • Used to treat most common types of bacterial infections.
  • Side effects are generally not too bad compared to other antibiotics.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
Downsides and risks
  • Many bacteria have developed resistance to this antibiotic.
  • Can cause diarrhea, nausea, and vomiting.
  • Birth control pills may not work as well to prevent pregnancy when taking this medication.
  • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
  • If you have caffeine while on Ciprofloxacin, you may noticed increased effects of the caffeine.
  • Ciprofloxacin can make your skin more sensitive to the sun.
  • Can't be used if you've ever had myasthenia gravis.
  • Can cause diarrhea.
Tips from our pharmacists for people taking the medication
  • Finish all of your medicine even if you start to feel better. Stopping it early can cause the infection to come back stronger than before.
  • Can make your oral birth control less effective. Consult your doctor or pharmacist if you need to use backup.
  • Take with food if you're having upset stomach.
  • Store the liquid in the fridge and throw away after 10 days.
  • Shake the suspension thoroughly before using each dose.
  • If you notice pain in your Achilles tendons, contact your doctor.
  • Wear sunscreen if you're going to be out in the sun.
  • Take the medication exactly how the doctor tells you to.
  • Avoid taking this by itself with dairy products (milk, cheese, yogurt) or with juice with calcium.
  • Take this medication at least 2 hours before or 6 hours after any antacids with magnesium or aluminum or with any vitamins with calcium, iron or zinc.
  • Can cause diarrhea, nausea or vomiting.
  • Limit your caffeine intake while taking this medication.
Learn more
More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it
More about CiproSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cipro (ciprofloxacin)?
Worth itNot sureNot worth it