Compare Augmentin vs. Cipro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Augmentin
(Amoxicillin / Clavulanate)

Cipro
(Ciprofloxacin)

Kills bacteria. Augmentin (Amoxicillin / Clavulanate) is good for treating many bacterial infections and is available as generic. However, it will make birth control pills less effective. It also has to be taken with food since it can cause an upset stomach.Kills bacteria. Cipro (Ciprofloxacin) is a good and cheap antibiotic to treat many types of bacterial infections. However, you have to reduce your caffeine intake, and have to protect yourself from the sun.
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Reviews & ratings
Filter group. All currently selected
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5.293137254901961Augmentin
Reviews for Augmentin (Amoxicillin / Clavulanate)
68%
of people (All ages) say Augmentin (Amoxicillin / Clavulanate) is worth it
52%
say it works well
13%
say it's a big hassle
1020 reviews
Have you used Augmentin (Amoxicillin / Clavulanate)?
Worth itNot sureNot worth it
Reviews for Cipro (Ciprofloxacin)
64%
4% vs. Augmentin (Amoxicillin / Clavulanate)
53%
+1% vs. Augmentin (Amoxicillin / Clavulanate)
17%
4% vs. Augmentin (Amoxicillin / Clavulanate)
746 reviews
Have you used Cipro (Ciprofloxacin)?
Worth itNot sureNot worth it
Side effects
AugmentinCipro

The Augmentin FDA package insert doesn’t have numbers about how common side effects are.

More about Augmentin side effects »

The Cipro FDA package insert doesn’t have numbers about how common side effects are.

More about Cipro side effects »
How it works
AugmentinCipro
Augmentin (Amoxicillin / Clavulanate) is a combination antibiotic. Amoxicillin kills bacteria and prevents them from reproducing and making their own protective covering. Clavulanate stops chemicals the bacteria make to resist antibiotics.Cipro (Ciprofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
AugmentinCipro
Antibiotic
Penicillin
Prescription only
Antibiotic
Fluoroquinolone
Prescription only
Available as
AugmentinCipro
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Extended release
  • Infusion (IV)
Used for (click to learn more)
AugmentinCipro
Risk factors for serious side effects
AugmentinCipro
  • Mononucleosis
    • History of liver disease
      Detailed Augmentin (Amoxicillin / Clavulanate) risks & warnings »
      • Over 60 years of age
      • On long-term steroid use
      • Heart, kidney, or lung transplant
      • Myasthenia gravis
            Detailed Cipro (Ciprofloxacin) risks & warnings »
            Pregnancy

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Food
            AugmentinCipro
            • Should be taken with food since it can cause stomach upset.
            • Take each dose with a meal since it may cause an upset stomach.
            No food related info.
            Kidneys and liver
            AugmentinCipro
            • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
            No kidneys and liver related info.
            Pain
            AugmentinCipro
            No pain related info.
            • If you notice pain in your Achilles tendons, contact your doctor.
            • If you notice redness/inflammation, pain or swelling in your joints or muscles, especially in the Achilles tendon, contact your doctor immediately.
            • Talk to your doctor immediately if you start to feel burning, tingling, numbness, pain or you can't tolerate heat or cold. This could be a sign of nerve damage and it can happen as soon as you start taking the medication and may not go away if you stop it.
            Upsides and benefits
            AugmentinCipro
            • Available in generic.
            • Available in different forms: tablet, capsule, and suspension.
            • Used to treat many types of bacterial infections.
            • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
            • Available in generic.
            • Available in different forms: tablet, capsule, and suspension.
            • Used to treat many types of bacterial infections.
            • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
            Downsides and risks
            AugmentinCipro
            • If you're on birth control pills, you should use a barrier method (condoms, diaphragms) since Augmentin can make them less effective.
            • Should be taken with food since it can cause stomach upset.
            • If you have phenylketonuria (PKU), talk to your doctor to prescribe an alternative.
            • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
            • If you have caffeine while on Ciprofloxacin, you may noticed increased effects of the caffeine.
            • Ciprofloxacin can make your skin more sensitive to the sun.
            • Can't be used if you've ever had myasthenia gravis.
            • Can cause diarrhea.
            Tips from our pharmacists for people taking the medication
            AugmentinCipro
            • Take this medication exactly as your doctor tells you to.
            • Take each dose with a meal since it may cause an upset stomach.
            • If you are taking birth control pills, this can make it less effective.
            • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
            • If you notice pain in your Achilles tendons, contact your doctor.
            • Wear sunscreen if you're going to be out in the sun.
            • Take the medication exactly how the doctor tells you to.
            • Avoid taking this by itself with dairy products (milk, cheese, yogurt) or with juice with calcium.
            • Take this medication at least 2 hours before or 6 hours after any antacids with magnesium or aluminum or with any vitamins with calcium, iron or zinc.
            • Can cause diarrhea, nausea or vomiting.
            • Limit your caffeine intake while taking this medication.
            Learn more
            More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Augmentin (Amoxicillin / Clavulanate)?
            Worth itNot sureNot worth it
            More about CiproSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Cipro (Ciprofloxacin)?
            Worth itNot sureNot worth it