Compare Augmentin vs. Cleocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Augmentin
(Amoxicillin / Clavulanate)

Cleocin T
(Clindamycin Phosphate)

Kills bacteria. Augmentin (Amoxicillin / Clavulanate) is good for treating many bacterial infections and is available as generic. However, it will make birth control pills less effective. It also has to be taken with food since it can cause an upset stomach.Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.293137254901961Augmentin
Reviews for Augmentin (Amoxicillin / Clavulanate)
68%
of people say Augmentin (Amoxicillin / Clavulanate) is worth it
52%
say it works well
13%
say it's a big hassle
Reviews for Cleocin T (Clindamycin Phosphate)
57%
11% vs. Augmentin (Amoxicillin / Clavulanate)
43%
9% vs. Augmentin (Amoxicillin / Clavulanate)
20%
7% vs. Augmentin (Amoxicillin / Clavulanate)
Side effects
AugmentinCleocin

The Augmentin FDA package insert doesn’t have numbers about how common side effects are.

More about Augmentin side effects »
  • Vaginal moniliasis 6%
More Cleocin side effects »
How it works
AugmentinCleocin
Augmentin (Amoxicillin / Clavulanate) is a combination antibiotic. Amoxicillin kills bacteria and prevents them from reproducing and making their own protective covering. Clavulanate stops chemicals the bacteria make to resist antibiotics.Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
AugmentinCleocin
Antibiotic
Penicillin
Prescription only
Acne agent
Antibiotic
Prescription only
Available as
AugmentinCleocin
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
Used for (click to learn more)
AugmentinCleocin
Risk factors for serious side effects
AugmentinCleocin
  • Mononucleosis
    • History of liver disease
      Detailed Augmentin (Amoxicillin / Clavulanate) risks & warnings »
        • History of liver disease
          Detailed Cleocin T (Clindamycin Phosphate) risks & warnings »
          Pregnancy category
          AugmentinCleocin
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Should be taken with food since it can cause stomach upset.
          • Take each dose with a meal since it may cause an upset stomach.
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • Can be taken with or without food.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          AugmentinCleocin
          • Available in different forms: tablet, capsule, and suspension.
          • Available in generic.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Topical form treats acne.
          • Available in different oral forms: tablet, capsule, and suspension.
          • Available in forms to treat skin infections and vaginal infections.
          • Can be taken with or without food.
          • Available in generic.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          Downsides and risks
          AugmentinCleocin
          • If you're on birth control pills, you should use a barrier method (condoms, diaphragms) since Augmentin can make them less effective.
          • Should be taken with food since it can cause stomach upset.
          • If you have phenylketonuria (PKU), talk to your doctor to prescribe an alternative.
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
          • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
          • If you're taking the topical form, it can cause sensitivity and irritation.
          Tips from our pharmacists for people taking the medication
          AugmentinCleocin
          • Take this medication exactly as your doctor tells you to.
          • Take each dose with a meal since it may cause an upset stomach.
          • If you are taking birth control pills, this can make it less effective.
          • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
          • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
          • Take this medication exactly how your doctor tells you to.
          • Store the suspension at room temperature.
          • If you're using the topical form, it can take a few weeks to see the full effect.
          • Keep the topical form out of your eyes, nose and mouth.
          • If you're using the topical form, Don't put makeup or bandages over it.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          Learn more
          More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
          More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert