Compare Augmentin vs. Doxycycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Augmentin
(amoxicillin / clavulanate)

Vibramycin
(doxycycline)

Treats bacterial infections. Augmentin (amoxicillin / clavulanate) is first-choice antibiotic for most common types of infections. However, it may not work against more serious or uncommon types of infections.Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.28Augmentin
Reviews for Augmentin
68%
of people (All ages) say Augmentin is worth it
52%
say it works well
13%
say it's a big hassle
1034 reviews
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it
Reviews for Doxycycline
49%
+19% better vs. Augmentin
36%
+16% better vs. Augmentin
24%
+11% better vs. Augmentin
112 reviews
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
Side effects
AugmentinDoxycycline
  • Diarrhea 9%
  • Nausea 3%
  • Skin rash and hives 3%
More Augmentin side effects »
  • Any adverse event 40%
  • Nausea 13%
  • Vomiting 8%
  • Diarrhea 3%
  • Bacterial vaginitis 3%
  • Headache 2%
  • Upper abdominal pain 2%
  • Vaginal yeast infection 2%
More Doxycycline side effects »
How it works
AugmentinDoxycycline
Augmentin (amoxicillin / clavulanate) contains two antibiotic medicines, which kill bacteria.Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
AugmentinDoxycycline
Prescription onlyPrescription only
Available as
AugmentinDoxycycline
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Delayed release capsule
  • Liquid
Used for
AugmentinDoxycycline
Risk factors for serious side effects
AugmentinDoxycycline
  • History of penicillin allergies
  • Taking Augmentin (amoxicillin / clavulanate) for a long time
  • Mononucleosis
  • Using oral birth control pills
Detailed Augmentin (amoxicillin / clavulanate) risks & warnings »
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
  • Women of childbearing age
Detailed Vibramycin (doxycycline) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
AugmentinDoxycycline
  • Take with food if you're having upset stomach.
No food related info.
Kidneys and liver
AugmentinDoxycycline
  • Liver damage has been associated with patients taking Augmentin (amoxicillin / clavulanate). It's usually reversible, but deaths have been reported. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
No kidneys and liver related info.
Upsides and benefits
AugmentinDoxycycline
  • Available as generic product.
  • Available in tablet, capsule, and liquid forms.
  • Used to treat most common types of bacterial infections.
  • Side effects are generally not too bad compared to other antibiotics.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
Downsides and risks
AugmentinDoxycycline
  • Many bacteria have developed resistance to this antibiotic.
  • Can cause diarrhea, nausea, and vomiting.
  • Birth control pills may not work as well to prevent pregnancy when taking this medication.
  • Can't be used in pregnant women and children under 8 years old.
  • Makes your skin more sensitive to the sun.
  • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
  • Can make birth control less effective.
  • Can cause diarrhea.
Tips from our pharmacists for people taking the medication
AugmentinDoxycycline
  • Finish all of your medicine even if you start to feel better. Stopping it early can cause the infection to come back stronger than before.
  • Can make your oral birth control less effective. Consult your doctor or pharmacist if you need to use backup.
  • Take with food if you're having upset stomach.
  • Store the liquid in the fridge and throw away after 10 days.
  • Shake the suspension thoroughly before using each dose.
  • Take the medication exactly how your doctor tells you to.
  • If you're using birth control pills, this medication can make them less effective.
  • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
  • Can cause diarrhea, nausea or vomiting.
  • Space out any vitamins by at least two hours.
  • Take with plenty of food and liquids.
  • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
  • Don't lie down for at least 30 minutes after taking this medication.
Learn more
More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it
More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it