Compare Augmentin vs. Doxycycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Augmentin
(Amoxicillin / Clavulanate)

Vibramycin
(Doxycycline)

Kills bacteria. Augmentin (Amoxicillin / Clavulanate) is good for treating many bacterial infections and is available as generic. However, it will make birth control pills less effective. It also has to be taken with food since it can cause an upset stomach.Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.28Augmentin
Reviews for Augmentin (Amoxicillin / Clavulanate)
68%
of people (All ages) say Augmentin (Amoxicillin / Clavulanate) is worth it
52%
say it works well
13%
say it's a big hassle
1034 reviews
Have you used Augmentin (Amoxicillin / Clavulanate)?
Worth itNot sureNot worth it
Reviews for Vibramycin (Doxycycline)
49%
-19% worse vs. Augmentin (Amoxicillin / Clavulanate)
36%
-16% worse vs. Augmentin (Amoxicillin / Clavulanate)
24%
-11% worse vs. Augmentin (Amoxicillin / Clavulanate)
112 reviews
Have you used Vibramycin (Doxycycline)?
Worth itNot sureNot worth it
Side effects
AugmentinDoxycycline
  • Diarrhea 9%
  • Nausea 3%
  • Skin rashes and urticaria 3%
More Augmentin side effects »
  • Any adverse event 40%
  • Nausea 13%
  • Vomiting 8%
  • Diarrhea 3%
  • Bacterial vaginitis 3%
  • Headache 2%
  • Upper abdominal pain 2%
  • Vaginal yeast infection 2%
More Doxycycline side effects »
How it works
AugmentinDoxycycline
Augmentin (Amoxicillin / Clavulanate) is a combination antibiotic. Amoxicillin kills bacteria and prevents them from reproducing and making their own protective covering. Clavulanate stops chemicals the bacteria make to resist antibiotics.Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
AugmentinDoxycycline
Prescription only
Prescription only
Available as
AugmentinDoxycycline
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Delayed release capsule
  • Liquid
Used for
AugmentinDoxycycline
Risk factors for serious side effects
AugmentinDoxycycline
  • Mononucleosis
    • History of liver disease
      Detailed Augmentin (Amoxicillin / Clavulanate) risks & warnings »
      • Age 8 years or younger
      • Using oral birth control pills
      • Long antibiotic treatment period
          • Women of childbearing age
          • Women of childbearing age
          • Overweight or obese
          • Taking isotretinoin (Accutane)
          Detailed Vibramycin (Doxycycline) risks & warnings »
          Pregnancy

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Food
          AugmentinDoxycycline
          • Should be taken with food since it can cause stomach upset.
          • Take each dose with a meal since it may cause an upset stomach.
          No food related info.
          Kidneys and liver
          AugmentinDoxycycline
          • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
          No kidneys and liver related info.
          Upsides and benefits
          AugmentinDoxycycline
          • Available in generic.
          • Available in different forms: tablet, capsule, and suspension.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Available in generic.
          • Available in different forms: tablet, capsule, and suspension.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          Downsides and risks
          AugmentinDoxycycline
          • If you're on birth control pills, you should use a barrier method (condoms, diaphragms) since Augmentin can make them less effective.
          • Should be taken with food since it can cause stomach upset.
          • If you have phenylketonuria (PKU), talk to your doctor to prescribe an alternative.
          • Can't be used in pregnant women and children under 8 years old.
          • Makes your skin more sensitive to the sun.
          • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
          • Can make birth control less effective.
          • Can cause diarrhea.
          Tips from our pharmacists for people taking the medication
          AugmentinDoxycycline
          • Take this medication exactly as your doctor tells you to.
          • Take each dose with a meal since it may cause an upset stomach.
          • If you are taking birth control pills, this can make it less effective.
          • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
          • Take the medication exactly how your doctor tells you to.
          • If you're using birth control pills, this medication can make them less effective.
          • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
          • Can cause diarrhea, nausea or vomiting.
          • Space out any vitamins by at least two hours.
          • Take with plenty of food and liquids.
          • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
          • Don't lie down for at least 30 minutes after taking this medication.
          Learn more
          More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Augmentin (Amoxicillin / Clavulanate)?
          Worth itNot sureNot worth it
          More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Vibramycin (Doxycycline)?
          Worth itNot sureNot worth it