Compare Augmentin vs. Keflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Augmentin
(Amoxicillin / Clavulanate)

Keflex
(Cephalexin)

Kills bacteria. Augmentin (Amoxicillin / Clavulanate) is good for treating many bacterial infections and is available as generic. However, it will make birth control pills less effective. It also has to be taken with food since it can cause an upset stomach.Kills bacteria. Keflex (Cephalexin) is good for treating many bacterial infections and is available as generic. However, if you are on medications to thin your blood, you can be more likely to bleed.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.293137254901961Augmentin
Reviews for Augmentin (Amoxicillin / Clavulanate)
68%
of people say Augmentin (Amoxicillin / Clavulanate) is worth it
52%
say it works well
13%
say it's a big hassle
Reviews for Keflex (Cephalexin)
63%
5% vs. Augmentin (Amoxicillin / Clavulanate)
48%
4% vs. Augmentin (Amoxicillin / Clavulanate)
14%
1% vs. Augmentin (Amoxicillin / Clavulanate)
Side effects
AugmentinKeflex

The Augmentin FDA package insert doesn’t have numbers about how common side effects are.

More about Augmentin side effects »

The Keflex FDA package insert doesn’t have numbers about how common side effects are.

More about Keflex side effects »
How it works
AugmentinKeflex
Augmentin (Amoxicillin / Clavulanate) is a combination antibiotic. Amoxicillin kills bacteria and prevents them from reproducing and making their own protective covering. Clavulanate stops chemicals the bacteria make to resist antibiotics.Keflex (Cephalexin) is an antibiotic. It kills bacteria by preventing them from making their own protective covering.
Type of medication
AugmentinKeflex
Antibiotic
Penicillin
Prescription only
Antibiotic
Cephalosporin
Prescription only
Available as
AugmentinKeflex
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Powder for oral suspension
Used for (click to learn more)
AugmentinKeflex
Risk factors for serious side effects
AugmentinKeflex
  • Mononucleosis
    • History of liver disease
      Detailed Augmentin (Amoxicillin / Clavulanate) risks & warnings »
        Detailed Keflex (Cephalexin) risks & warnings »
        Pregnancy category
        AugmentinKeflex
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Should be taken with food since it can cause stomach upset.
        • Take each dose with a meal since it may cause an upset stomach.
        • Can be taken with or without food.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        AugmentinKeflex
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
        • Can be taken with or without food.
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
        Downsides and risks
        AugmentinKeflex
        • If you're on birth control pills, you should use a barrier method (condoms, diaphragms) since Augmentin can make them less effective.
        • Should be taken with food since it can cause stomach upset.
        • If you have phenylketonuria (PKU), talk to your doctor to prescribe an alternative.
        • If you're on blood thinners (anticoagulants), talk to your doctor, it may make you more likely to bleed.
        • If you have to take any live vaccines, talk to your doctor. You may have to postpone it.
        • Can cause diarrhea.
        Tips from our pharmacists for people taking the medication
        AugmentinKeflex
        • Take each dose with a meal since it may cause an upset stomach.
        • If you are taking birth control pills, this can make it less effective.
        • Take this medication exactly as your doctor tells you to.
        • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
        • Space out vitamins by a couple hours if you're taking this medication.
        • Take this medication exactly as your doctor tells you to.
        • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
        Learn more
        More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
        More about KeflexSide effectsReviews & ratingsAlternativesFDA package insert