Compare Augmentin vs. Keflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Augmentin
(amoxicillin / clavulanate)

Keflex
(cephalexin)

Treats bacterial infections. Augmentin (amoxicillin / clavulanate) is first-choice antibiotic for most common types of infections. However, it may not work against more serious or uncommon types of infections.Treats bacterial infections. Keflex (cephalexin) is good for treating many bacterial infections, and is available as a generic.
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Coupons for Keflex
Best available price for 40 (500mg) capsules of cephalexin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.28Augmentin
Reviews for Augmentin (amoxicillin / clavulanate)
68%
of people (All ages) say Augmentin (amoxicillin / clavulanate) is worth it
52%
say it works well
13%
say it's a big hassle
1034 reviews
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it
Reviews for Keflex (cephalexin)
64%
-4% worse vs. Augmentin (amoxicillin / clavulanate)
48%
-4% worse vs. Augmentin (amoxicillin / clavulanate)
14%
-1% worse vs. Augmentin (amoxicillin / clavulanate)
686 reviews
Have you used Keflex (cephalexin)?
Worth itNot sureNot worth it
Side effects
AugmentinKeflex
  • Diarrhea 9%
  • Nausea 3%
  • Skin rash and hives 3%
More Augmentin side effects »

The Keflex FDA package insert doesn’t have numbers about how common side effects are.

More about Keflex side effects »
How it works
AugmentinKeflex
Augmentin (amoxicillin / clavulanate) contains two antibiotic medicines, which kill bacteria.Keflex (cephalexin) is an antibiotic. It kills bacteria by preventing them from making their own protective covering.
Type of medication
AugmentinKeflex
Prescription only
Prescription only
Available as
AugmentinKeflex
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Liquid
Used for
AugmentinKeflex
Risk factors for serious side effects
AugmentinKeflex
  • History of penicillin allergies
  • Taking Augmentin (amoxicillin / clavulanate) for a long time
  • Mononucleosis
  • Using oral birth control pills
Detailed Augmentin (amoxicillin / clavulanate) risks & warnings »
  • Weakened immune system
  • Not taking Keflex (cephalexin) correctly
  • History of penicillin or cephalosporin allergies
Detailed Keflex (cephalexin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
AugmentinKeflex
  • Take with food if you're having upset stomach.
  • Can be taken with or without food.
  • Can take with or without food.
Kidneys and liver
AugmentinKeflex
  • Liver damage has been associated with patients taking Augmentin (amoxicillin / clavulanate). It's usually reversible, but deaths have been reported. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
No kidneys and liver related info.
Upsides and benefits
AugmentinKeflex
  • Available as generic product.
  • Available in tablet, capsule, and liquid forms.
  • Used to treat most common types of bacterial infections.
  • Side effects are generally not too bad compared to other antibiotics.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Can be taken with or without food.
  • Generally few side effects compared with other antibiotics.
Downsides and risks
AugmentinKeflex
  • Many bacteria have developed resistance to this antibiotic.
  • Can cause diarrhea, nausea, and vomiting.
  • Birth control pills may not work as well to prevent pregnancy when taking this medication.
  • Can cause diarrhea.
  • You may need to take Keflex (cephalexin) 2 to 4 times a day, which can be hard to remember.
  • If you're allergic to penicillins or other antibiotics, you might not be able to take this medicine.
Tips from our pharmacists for people taking the medication
AugmentinKeflex
  • Finish all of your medicine even if you start to feel better. Stopping it early can cause the infection to come back stronger than before.
  • Can make your oral birth control less effective. Consult your doctor or pharmacist if you need to use backup.
  • Take with food if you're having upset stomach.
  • Store the liquid in the fridge and throw away after 10 days.
  • Shake the suspension thoroughly before using each dose.
  • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance.
  • Store the suspension in the refrigerator. Shake well before using, and discard the bottle after 14 days.
  • Can take with or without food.
Learn more
More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it
More about KeflexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Keflex (cephalexin)?
Worth itNot sureNot worth it