Compare Augmentin vs. Keflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats bacterial infections.

Augmentin (amoxicillin / clavulanate) is first-choice antibiotic for most common types of infections. However, it may not work against more serious or uncommon types of infections.

3.9/ 5 average rating with 1034 reviewsforAugmentin
Treats bacterial infections.

Keflex (cephalexin) is good for treating many bacterial infections, and is available as a generic.

3.7/ 5 average rating with 686 reviewsforKeflex
Upsides
  • Available as generic product.
  • Available in tablet, capsule, and liquid forms.
  • Used to treat most common types of bacterial infections.
  • Side effects are generally not too bad compared to other antibiotics.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Can be taken with or without food.
  • Generally few side effects compared with other antibiotics.
Downsides
  • Many bacteria have developed resistance to this antibiotic.
  • Can cause diarrhea, nausea, and vomiting.
  • Birth control pills may not work as well to prevent pregnancy when taking this medication.
  • Can cause diarrhea.
  • You may need to take Keflex (cephalexin) 2 to 4 times a day, which can be hard to remember.
  • If you're allergic to penicillins or other antibiotics, you might not be able to take this medicine.
Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
1034 reviews so far
68%
saidit'sworth it
52%
saiditworked well
13%
saidit'sa big hassle

Have you used Augmentin (amoxicillin / clavulanate)?

Leave a review
686 reviews so far
64%
saidit'sworth it
48%
saiditworked well
14%
saidit'sa big hassle

Have you used Keflex (cephalexin)?

Leave a review
Side effects
3possible side effects
  • Diarrhea
    15%
  • Vaginal yeast infection
    3%
  • Nausea
    2%
See more detailed side effects
The Keflex (cephalexin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serious allergic reaction
    • History of penicillin allergy
    • History of multiple allergies
  • Liver damage
    • Existing liver problems
    • Taking other medicines that harm the liver
  • Superinfection
    • Taking Augmentin (amoxicillin / clavulanate) for a long time
    • Older age
    • Taking immunosuppressant medicines
  • Rash
    • Mononucleosis
See more detailed risks and warnings
  • Diarrhea
  • New infections while taking Keflex (cephalexin)
    • Weakened immune system
    • Not taking Keflex (cephalexin) correctly
  • Allergic reaction
    • History of penicillin or cephalosporin allergies
See more detailed risks and warnings