Compare Augmentin vs. Penicillin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats bacterial infections.

Augmentin (amoxicillin / clavulanate) is first-choice antibiotic for most common types of infections. However, it may not work against more serious or uncommon types of infections.

3.9/ 5 average rating with 1034 reviewsforAugmentin
Kills bacteria.

Penicillin Vk (Penicillin) is good for treating many bacterial infections and is available as a generic. You may need to use another form of birth control along with your birth control pills. It's also best taken on an empty stomach but it can cause an upset stomach.

3.9/ 5 average rating with 1297 reviewsforPenicillin
Upsides
  • Available as generic product.
  • Available in tablet, capsule, and liquid forms.
  • Used to treat most common types of bacterial infections.
  • Side effects are generally not too bad compared to other antibiotics.
  • Available in generic.
  • Available in different forms: tablet, capsule and suspension.
  • Used to treat many types of bacterial infections.
Downsides
  • Many bacteria have developed resistance to this antibiotic.
  • Can cause diarrhea, nausea, and vomiting.
  • Birth control pills may not work as well to prevent pregnancy when taking this medication.
  • Many bacteria have developed resistance. Your doctor may run tests to see if Penicillin will work on your infection.
  • Can make birth control pills less effective.
  • Best taken on an empty stomach, but can cause stomach upset and diarrhea.
Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
Price
No pricing information available
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Reviews
1034 reviews so far
68%
saidit'sworth it
52%
saiditworked well
13%
saidit'sa big hassle

Have you used Augmentin (amoxicillin / clavulanate)?

Leave a review
1297 reviews so far
71%
saidit'sworth it
52%
saiditworked well
12%
saidit'sa big hassle

Have you used Penicillin Vk (Penicillin)?

Leave a review
Side effects
3possible side effects
  • Diarrhea
    15%
  • Vaginal yeast infection
    3%
  • Nausea
    2%
See more detailed side effects
The Penicillin Vk (Penicillin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serious allergic reaction
    • History of penicillin allergy
    • History of multiple allergies
  • Liver damage
    • Existing liver problems
    • Taking other medicines that harm the liver
  • Superinfection
    • Taking Augmentin (amoxicillin / clavulanate) for a long time
    • Older age
    • Taking immunosuppressant medicines
  • Rash
    • Mononucleosis
See more detailed risks and warnings
  • Diarrhea
  • Decreased effectiveness of birth control pills
  • Allergic reactions
    • Prior severe allergic reaction to Penicillin Vk (Penicillin)
See more detailed risks and warnings