Compare Aveed vs. Axiron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aveed
(testosterone undecanoate injection)

Axiron
(testosterone topical solution)

Treats low testosterone. This testosterone injection is a first-choice treatment, but you have to get it in your doctor's office each time.Treats low testosterone. This testosterone topical solution is a convenient topical form of hormone replacement that's less likely to rub off on other people you come into contact with, but it's not available as a generic yet.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.85Aveed
Reviews for Aveed (testosterone undecanoate injection)
41%
of people (All ages) say Aveed (testosterone undecanoate injection) is worth it
22%
say it works well
18%
say it's a big hassle
Have you used Aveed (testosterone undecanoate injection)?
Worth itNot sureNot worth it
Reviews for Axiron (testosterone topical solution)
Not enough review data. Review it!
+26% better vs. Aveed (testosterone undecanoate injection)
Not enough review data. Review it!
+45% better vs. Aveed (testosterone undecanoate injection)
Not enough review data. Review it!
+1% better vs. Aveed (testosterone undecanoate injection)
Have you used Axiron (testosterone topical solution)?
Worth itNot sureNot worth it
Side effects
AveedAxiron
  • Acne 5%
  • Injection site pain 5%
  • Prostatic specific antigen increased 5%
  • Estradiol increased 3%
  • Hypogonadism 3%
  • Fatigue 2%
  • Irritability 2%
  • Hemoglobin increased 2%
  • Sleep difficulty 2%
  • Mood swings 2%
More Aveed side effects »
  • Application site irritation 8%
  • Hematocrit increased 7%
  • Application site erythema 7%
  • Headache 6%
  • Diarrhea 4%
  • Vomiting 4%
  • Psa increased 4%
More Axiron side effects »
How it works
AveedAxiron
The testosterone injection works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.Testosterone topical solution works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
AveedAxiron
Prescription only
Prescription only
Available as
AveedAxiron
  • Injection
  • Topical
Used for
AveedAxiron
  • Low Testosterone
  • Low Testosterone
Risk factors for serious side effects
AveedAxiron
  • Male
  • Enlarged prostate (benign prostatic hypertrophy)
  • Taking high doses of Aveed (Testosterone Undecanoate Injection)
  • Heart, liver or kidney disease
Detailed Aveed (testosterone undecanoate injection) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Kidneys and liver
    AveedAxiron
    • There have been reports of people on Aveed (Testosterone Undecanoate Injection) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This can happen if you are unable to move around or if you have cancer. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
    No kidneys and liver related info.
    Pain
    AveedAxiron
    • If you're on Aveed (Testosterone Undecanoate Injection), and you notice pain in your abdomen, or if your skin or the whites of your eyes turn yellow, call your doctor immediately. This can be liver damage.
    No pain related info.
    Upsides and benefits
    AveedAxiron
    • A first-choice treatment for low testosterone in men.
    • The first two shots are spaced out by a month, then each shot after that is given every 10 weeks.
    • Your doctor will give you the shot.
    • You're less likely with this formulation to transfer testosterone topical solution to another person since this is applied to the armpits -- unlike some other forms of topical testosterone.
    • You can use your regular deodorant or antiperspirant, but just make sure to apply that first before using testosterone topical solution.
    Downsides and risks
    AveedAxiron
    • Your doctor has to give you this shot. You can't do it at home.
    • Your doctor has to watch you for 30 minutes after your shot to make sure you don't have problems breathing or get a severe allergic reaction.
    • Your doctor has to file paperwork each time you get the shot because of the risks involved.
    • Not available as a generic, so it can be expensive.
    • Only available as brand name.
    • You have to wait at least 2 hours after applying testosterone topical solution before you can swim or bathe, otherwise your body won't absorb the entire amount.
    Tips from our pharmacists for people taking the medication
    AveedAxiron
    • This medication is only available through a special screening program because of the side effects.
    • Your doctor will watch you for 30 minutes after each injection to make sure you don't have problems breathing or get an allergic reaction.
    • Can cause nausea, vomiting and headache.
    • Can cause increased acne and changes in sex drive.
    • Prime testosterone topical solution first by pumping 3 times before you use a new bottle.
    • If you use deodorant or antiperspirant, apply that first before using testosterone topical solution.
    • Don't swim or bathe for at least 2 hours after you put on testosterone topical solution so that it has time to absorb.
    • Cover the area with clothing as soon as it's dry so you don't spread it to other people.
    • If you think you'll have skin-to-skin contact at the area where you've placed testosterone topical solution, wash that area with soap and water then dry.
    • Don't use testosterone topical solution anywhere besides your armpits.
    Learn more
    More about AveedSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Aveed (testosterone undecanoate injection)?
    Worth itNot sureNot worth it
    More about AxironSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Axiron (testosterone topical solution)?
    Worth itNot sureNot worth it