Compare Avonex vs. Gilenya

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(Interferon Beta-1A)


Lowers the frequency of multiple sclerosis exacerbations. Avonex (Interferon Beta-1A) is an injectable medicine effective for relapsing, remitting MS and has manageable side effects and weekly dosing.Treats relapsing forms of multiple sclerosis. Gilenya (Fingolimod) is an oral medication that has a lot of side effects, but it reduces the number of flare-ups, slows physical changes, and decreases the number of new brain lesions in relapsing MS.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Avonex (Interferon Beta-1A)
of people say Avonex (Interferon Beta-1A) is worth it
say it works well
say it's a big hassle
Reviews for Gilenya (Fingolimod)
+4% vs. Avonex (Interferon Beta-1A)
+5% vs. Avonex (Interferon Beta-1A)
+4% vs. Avonex (Interferon Beta-1A)
Side effects
  • Flu-like symptoms 20%
  • Chills 14%
  • Fever 11%
  • Muscle pain 7%
  • Muscle weakness 6%
  • Nausea 4%
  • Injuction site inflammation 4%
  • Low mood disorder 4%
  • Infection 3%
  • Chest pain 3%
More Avonex side effects »
  • Alt/ast increased 9%
  • Diarrhea 5%
  • Back pain 5%
  • Ggt increased 4%
  • Bronchitis 4%
  • Migraine 4%
  • Vission blurred 3%
  • Abnormally slow heartbeat 3%
  • Influenza viral infections 3%
  • Tinea infections 3%
More Gilenya side effects »
How it works
Avonex (Interferon Beta-1A) is an interferon that acts like the ones your body naturally makes. Researchers don't know exactly how it works, but interferons activate your immune system to control immune responses that have gotten out of control.Gilenya (Fingolimod) is an immune modulator. Researchers don't know exactly how it works, but it seems to stop your white blood cells from attacking the nerves in your brain and spinal cord.
Type of medication
Multiple sclerosis treatment
Prescription only
Multiple sclerosis treatment, Immunosuppressant
Prescription only
Available as
  • Injection
  • Pill
Used for (click to learn more)
Risk factors for serious side effects
  • History of depression or mental illness
  • Allergy to albumin
  • Prolonged use of Avonex (Interferon Beta-1A)
  • Alcohol use
  • Taking drugs that are liver toxic
  • History of liver disease
    • History of heart disease
        • History of seizures
        • Women of childbearing age
          Detailed Avonex (Interferon Beta-1A) risks & warnings »
          • Taking with drugs that slow heart rate
          • History of heart problems
            • Taking other immunosuppressant drugs
            • Age 60 or older
            • Weak immune system
            • Diabetes
            • History of eye inflammation (uveitis)
            • Women of childbearing age
            • History of respiratory problems
            • History of liver problems
            Detailed Gilenya (Fingolimod) risks & warnings »
            Pregnancy category
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            No specific alcohol-related info.No specific alcohol-related info.
            No specific food-related info.
            • Take one capsule daily with or without food.
            Kidneys and liver
            No specific kidneys and liver-related info.No specific kidneys and liver-related info.
            No specific sex-related info.No specific sex-related info.
            No specific sleep-related info.No specific sleep-related info.
            • Avonex (Interferon Beta-1A) can cause serious liver injury with the risk increasing during the first 6 months after you start. You'll need to have your liver enzymes tested at 1, 3, and 6 months. If liver enzymes are significantly elevated and you have appetite/weight loss, stomach discomfort, vomiting, and notice dark urine, yellowing of skin/eyes, change in stool color, and skin rash, you should stop taking Avonex (Interferon Beta-1A) until your doctor decides if it's safe to re-start.
            No specific weight-related info.
            Upsides and benefits
            • One of the main treatments for relapsing MS that has been around for many years.
            • Injections are given weekly, and not daily like other MS medications.
            • Helps reduce the frequency of MS relapse episodes.
            • Flu-like reactions are the most common side effects and usually go away with continued treatment or can be avoided by using over-the-counter pain and fever-reducing medicines before the injection (like acetaminophen or ibuprofen).
            • Gilenya (Fingolimod) is the first once-daily pill you can take for relapsing forms of multiple sclerosis (MS).
            • Studies show it lowers relapse rates better than placebo and Avonex, and it delays the progression of physical disabilites better than placebo.
            • Gilenya also reduced the number of new MS lesions better than Avonex.
            Downsides and risks
            • Injection site reactions are common, ranging from localized pain, redness, and swelling to severe skin dryness.
            • Flu-like symptoms are common after interferon injections.
            • It's not clear what type of problems occur if taken during pregnancy.
            • Blood testing is required before and during use of Avonex (Interferon Beta-1A).
            • May not be as effective as other interferons.
            • Taking more than the 0.5 mg dose won't give more benefits, but will only cause more side effects.
            • Gilenya can remain in your blood for up to 2 months after you stop taking it. Your immune response won't work as well during this time.
            • Not the best choice if you've had a heart attack, stroke, or have been in the hospital for heart failure in the past 6 months. The risk of serious heart rate effects is higher when taken with certain drugs (methadone, erythromycin, citalopram, ketoconazole) or if you have low potassium or magnesium.
            • If you have to re-start Gilenya after stopping it for 2 weeks or more, you'll have to take your first dose at your doctor's office again.
            • If you didn't get chicken pox and never had a vaccination, you'll need to be vaccinated and wait one month before starting Gilenya.
            Tips from our pharmacists for people taking the medication
            • Inject yourself once a week in your muscle (you need to go deeper than the fat layer between your skin and muscle).
            • Refrigerate the powder and pre-filled syringes and pens.
            • Don't shake the medicine once it is taken out of the refrigerator or mixed.
            • If using the pre-filled syringes, the tiny air bubbles won't hurt you.
            • Avonex (Interferon Beta-1A) can cause flu-like symptoms (headache, fever, muscle pain) right after injections, lasting minutes or hours.
            • Flu-like reactions usually go away with repeated treatments. Taking acetaminophen or ibuprofen 45 minutes before the injection can reduce the uncomfortable feeling.
            • Take one capsule daily with or without food.
            • It's very important you read the Gilenya Medication Guide. Don't change your dose or stop the medicine without asking your doctor.
            • You'll need to be watched for at least 6 hours in a doctor's office after taking your first dose because it can cause serious heart rate and blood pressure problems.
            • Gilenya increases your risk of infections. Get blood tests 6 months before starting treatment.
            • Use effective birth control or plan to stop Gilenya 2 months before getting pregnant. If you do become pregnant while on Gilenya (Fingolimod), you'll need to enroll in the Gilenya pregnancy registry.
            • Tell your doctor if you've had any vaccines recently. Don't get any live vaccines while taking Gilenya.
            • Your doctor will monitor your eyes, lungs, and liver for up to 2 months after stopping Gilenya.
            Learn more
            More about AvonexSide effectsReviews & ratingsAlternativesFDA package insert
            More about GilenyaSide effectsReviews & ratingsAlternativesFDA package insert