Compare Axiron vs. Testopel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Axiron
(Testosterone Topical Solution)

Testopel
(Testosterone Implant)

Treats low testosterone. This testosterone topical solution is a convenient topical form of hormone replacement that's less likely to rub off on other people you come into contact with, but it's not available as a generic yet.Treats low testosterone. The testosterone implant is a good option for long-term testosterone therapy, but it can be expensive, and it's really important that you get the right dose so your doctor doesn't have to remove pellets.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Button Group. All currently active
Button Group. All currently active

Not enough reviews for this drug. Help someone out, leave a review!

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
AxironTestopel

The Axiron FDA package insert doesn’t have numbers about how common side effects are.

More about Axiron side effects »

The Testopel FDA package insert doesn’t have numbers about how common side effects are.

More about Testopel side effects »
How it works
AxironTestopel
Testosterone topical solution works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.The testosterone implant works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
AxironTestopel
Hormone replacement
Testosterone
Prescription only
Hormone replacement
Testosterone
Prescription only
Available as
AxironTestopel
  • Topical
  • Implant pellet
Used for (click to learn more)
AxironTestopel
  • Low testosterone
  • Low testosterone
Risk factors for serious side effects
AxironTestopel
Coming soon.Coming soon.
Pregnancy category
AxironTestopel
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.
  • Can cause increased acne and changes in sex drive.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
AxironTestopel
  • You're less likely with this formulation to transfer testosterone topical solution to another person since this is applied to the armpits -- unlike some other forms of topical testosterone.
  • You can use your regular deodorant or antiperspirant, but just make sure to apply that first before using testosterone topical solution.
  • Your doctor will give this shot to you every 3 months, so you don't have to worry about administering it yourself like some testosterone injections.
  • Unlike topical forms of testosterone, you don't have to worry about accidentally transferring this medication to another person's skin.
Downsides and risks
AxironTestopel
  • Only available as brand name.
  • You have to wait at least 2 hours after applying testosterone topical solution before you can swim or bathe, otherwise your body won't absorb the entire amount.
  • Not available in generic form, so it can be more expensive.
  • Your doctor has to calculate your dose for 3 months. If it ends up being too much, the doctor might have to remove some of the implant pellets.
  • The pellets can come out, although this is extremely rare.
Tips from our pharmacists for people taking the medication
AxironTestopel
  • Prime testosterone topical solution first by pumping 3 times before you use a new bottle.
  • If you use deodorant or antiperspirant, apply that first before using testosterone topical solution.
  • Don't swim or bathe for at least 2 hours after you put on testosterone topical solution so that it has time to absorb.
  • Cover the area with clothing as soon as it's dry so you don't spread it to other people.
  • If you think you'll have skin-to-skin contact at the area where you've placed testosterone topical solution, wash that area with soap and water then dry.
  • Don't use testosterone topical solution anywhere besides your armpits.
  • Your doctor will give this you as a shot underneath your skin every 3 months.
  • Can cause nausea, vomiting and headache.
  • Can cause increased acne and changes in sex drive.
Learn more
More about AxironSide effectsReviews & ratingsAlternativesFDA package insert
More about TestopelSide effectsReviews & ratingsAlternativesFDA package insert