Compare Aygestin vs. Prefest

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aygestin
(norethindrone)

Prefest
(estradiol / norgestimate)

Regulates your menstrual cycle and treats irregular bleeding. Aygestin (norethindrone) regulates the menstrual cycle and treats heavy or irregular vaginal bleeding. It's easy to take and isn't expensive.Relieves menopause symptoms and lowers your risk of osteoporosis. Prefest (Estradiol / Norgestimate) is effective at treating symptoms related to menopause and bone loss. It has a difficult dosing schedule to follow, but doesn't affect your cholesterol and triglyceride levels as much as other estrogen products.
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Coupons for Aygestin
Best available price for 30 (5mg) tablets of aygestin
Coupons for Prefest
Best available price for 30 (30 tablets) packages of prefest
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.6Aygestin
Reviews for Aygestin
40%
of people (All ages) say Aygestin is worth it
23%
say it works well
23%
say it's a big hassle
Have you used Aygestin (norethindrone)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Prefest (estradiol / norgestimate)?
Worth itNot sureNot worth it
Side effects
AygestinPrefest

The Aygestin FDA package insert doesn’t have numbers about how common side effects are.

More about Aygestin side effects »
  • Headache 23%
  • Upper respiratory-tract infection 21%
  • Breast pain 16%
  • Back pain 12%
  • Abdominal pain 12%
  • Flu-like symptomsa-like symptoms 11%
  • Joint pain 9%
  • Vaginal bleeding (all) 9%
  • Menstrual cramps 8%
  • Sinus inflammation 8%
More Prefest side effects »
How it works
AygestinPrefest
Aygestin (norethindrone) contains norethindrone, a synthetic progesterone hormone. It regulates your period, treats irregular vaginal bleeding, and eases the pain of endometriosis (a condition where tissue that lines your uterus is found in other parts of the body).Prefest (Estradiol / Norgestimate) is a combination oral medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norgestimate (a progestin) protects the uterus from damage.
Type of medication
AygestinPrefest
Prescription onlyPrescription only
Available as
AygestinPrefest
  • Pill
  • Pill
Used for
AygestinPrefest
  • Pain Caused By Endometriosis
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
AygestinPrefest
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • History of depression
Detailed Aygestin (norethindrone) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Prefest (estradiol / norgestimate) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Kidneys and liver
AygestinPrefest
  • Aygestin (norethindrone) is broken down by the liver, so if the liver is damaged, the drug can build up in your body. Tell your doctor if you've had liver disease or damage. Your doctor will have to change Aygestin (norethindrone) to a different medicine.
No kidneys and liver related info.
Pain
AygestinPrefest
  • Aygestin (norethindrone) can raise your risk of blood clots, which can be very dangerous. You're more likely to have them if you smoke tobacco, are obese, or if you or your family have ever had blood clots. Get medical care right away if you have pain in your legs or arms, bad headaches, trouble breathing, or sudden changes in your speech or vision.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
No pain related info.
Weight
AygestinPrefest
  • Aygestin (norethindrone) can cause cramps, bloating, trouble sleeping, acne, weight gain, or irregular periods.
  • Can make you gain weight.
  • Prefest (Estradiol / Norgestimate) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
Upsides and benefits
AygestinPrefest
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Available as a generic medication, so it costs less.
  • Prefest (Estradiol / Norgestimate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The norgestimate (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Doesn't affect your cholesterol levels as much as other estrogen treatments.
Downsides and risks
AygestinPrefest
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • Can cause a lot of side effects.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norgestimate (a progestin).
  • Dosing schedule can be hard to follow with the 2 different kind of pills (estrogen-only and estrogen/progestin pills).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Tips from our pharmacists for people taking the medication
AygestinPrefest
  • The dose of Aygestin (norethindrone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • It's important to take it at the same time every day.
  • Talk to your doctor every few months about using the lowest possible dose of Aygestin (norethindrone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • If you're taking Aygestin (norethindrone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Aygestin (norethindrone).
  • Aygestin (norethindrone) can cause cramps, bloating, trouble sleeping, acne, weight gain, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Follow the dosing schedule exactly to take the estrogen-only and combination estrogen/progestin pills.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about AygestinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aygestin (norethindrone)?
Worth itNot sureNot worth it
More about PrefestSide effectsAlternativesFDA package insert
Have you used Prefest (estradiol / norgestimate)?
Worth itNot sureNot worth it